Sfoglia per Autore
Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity
2023-01-01 Moi, Davide; Deplano, Alessandro; Angeli, Andrea; Balboni, Gianfranco; Supuran, Claudiu T.; Onnis, Valentina
Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition
2022-01-01 Morgillo, Carmine Marco; Lupia, Antonio; Deplano, Alessandro; Pirone, Luciano; Fiorillo, Bianca; Pedone, Emilia; Luque, F. Javier; Onnis, Valentina; Moraca, Federica; Catalanotti, Bruno
Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents
2021-01-01 Deplano, Alessandro; Karlsson, Jessica; Moraca, Federica; Svensson, Mona; Cristiano, Claudia; Morgillo, Carmine Marco; Fowler, Christopher J.; Russo, Roberto; Catalanotti, Bruno; Onnis, Valentina
Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen
2020-01-01 Deplano, Alessandro; Karlsson, Jessica; Svensson, Mona; Moraca, Federica; Catalanotti, Bruno; Fowler, Christopher J.; Onnis, Valentina
Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors
2020-01-01 Moi, Davide; Nocentini, Alessio; Deplano, Alessandro; Osman, Sameh M.; Alothman, Zeid A.; Piras, Valentina; Balboni, Gianfranco; Supuran, Claudiu T.; Onnis, Valentina
The fatty acid amide hydrolase and cyclooxygenase-inhibitory properties of novel amide derivatives of carprofen
2020-01-01 Deplano, Alessandro; Karlsson, Jessica; Fowler, Christopher J.; Onnis, Valentina
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors
2020-01-01 Nocentini, Alessio; Moi, Davide; Deplano, Alessandro; Osman, Sameh M.; Alothman, Zeid A.; Balboni, Gianfranco; Supuran, Claudiu T.; Onnis, Valentina
Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation
2019-01-01 Moi, Davide; Nocentini, Alessio; Deplano, Alessandro; Balboni, Gianfranco; Supuran, Claudiu T.; Onnis, Valentina
Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors
2019-01-01 Moi, Davide; Foster, Paul A.; Rimmer, Lucy G.; Jaffri, Alisha; Deplano, Alessandro; Balboni, Gianfranco; Onnis, Valentina; Potter, Barry V. L.
Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors
2019-01-01 Deplano, Alessandro; Cipriano, Mariateresa; Moraca, Federica; Novellino, Ettore; Catalanotti, Bruno; Fowler, Christopher J.; Onnis, Valentina
Onthe use (QM) IEF/PMC-MST-derived hydrophobic contributions as physicochemical descriptors in 3D-QSAR: the PHARMSQSARTM approach
2018-01-01 Rey, Oscar; Ginex, Tiziana; Vazquez, Javier; Deplano, Alessandro; Herrero, Albert; Gibert, Enric; Herrero, Enric; Javier Luque, Francisco
Development and Validation of Molecular Overlays Derived from Three-Dimensional Hydrophobic Similarity with PharmScreen
2018-01-01 Vázquez, J.; Deplano, A.; Herrero, A.; Ginex, T.; Gibert, E.; Rabal, O.; Oyarzabal, J.; Herrero, E.; Luque, F. J.
Hydrophobic similarity between molecules: Application to three-dimensional molecular overlays with PharmScreen
2018-01-01 Vazquez, Javier; Deplano, Alessandro; Herrero, Albert; Gibert, Enric; Ginex, Tiziana; Rabal, Obdulia; Oyarzabal, Julen; Herrero, Enric; Luque, F Javier
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions
2017-01-01 Corona, Angela; Onnis, Valentina; Deplano, Alessandro; Bianco, Giulia; Demurtas, Monica; Distinto, Simona; Cheng, Yung Chi; Alcaro, Stefano; Esposito, Francesca; Tramontano, Enzo
Novel propanamides as fatty acid amide hydrolase inhibitors
2017-01-01 Deplano, Alessandro; Morgillo, Carmine Marco; Demurtas, Monica; Björklund, Emmelie; Cipriano, Mariateresa; Svensson, Mona; Hashemian, Sanaz; Smaldone, Giovanni; Pedone, Emilia; Luque, F. Javier; Cabiddu, MARIA GRAZIA; Novellino, Ettore; Fowler, Christopher J.; Catalanotti, Bruno; Onnis, Valentina
Design, synthesis and SAR of small molecules acting on pain pathways
2016-03-24
DIHYDROQUINAZOLINE BENZYLAMIDES AS ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORS
2016-01-01 Onnis, Valentina; Balboni, Gianfranco; Deplano, Alessandro; Demurtas, Monica; Buyn, Joon Seok; Sohn, Joo Mi; Lee, Jae Yeol; Catto, Marco; Pisani, Leonardo; Carotti, Angelo
DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NEW DNA METHYLTRANSFERASE INHIBITORS
2016-01-01 Balboni, Gianfranco; Deplano, Alessandro; Demurtas, Monica; Arimondo, Paola B.; Masson, Veronique; Onnis, Valentina
Discovery of a novel class of profen derivatives as FAAH inhibitors: MD and QM/MM studies of the binding mode and 3D SAR
2016-01-01 Morgillo, Cm; Deplano, Alessandro; Karlsson, J; Cipriano, M; Björklund, E; Fowler, Cj; Onnis, Valentina; Luque, Fj; Catalanotti, B.
Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy
2016-01-01 Costanzi, Stefano; Skorski, Matthew; Deplano, Alessandro; Habermehl, Brett; Mendoza, Mary; Wang, Keyun; Biederman, Michelle; Dawson, Jessica; Gaoa, Jia
| Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
|---|---|---|---|---|
| Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity | 1-gen-2023 | Moi, Davide; Deplano, Alessandro; Angeli, Andrea; Balboni, Gianfranco; Supuran, Claudiu T.; Onnis, Valentina | MOLECULES | - |
| Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition | 1-gen-2022 | Morgillo, Carmine Marco; Lupia, Antonio; Deplano, Alessandro; Pirone, Luciano; Fiorillo, Bianca; Pedone, Emilia; Luque, F. Javier; Onnis, Valentina; Moraca, Federica; Catalanotti, Bruno | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
| Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents | 1-gen-2021 | Deplano, Alessandro; Karlsson, Jessica; Moraca, Federica; Svensson, Mona; Cristiano, Claudia; Morgillo, Carmine Marco; Fowler, Christopher J.; Russo, Roberto; Catalanotti, Bruno; Onnis, Valentina | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen | 1-gen-2020 | Deplano, Alessandro; Karlsson, Jessica; Svensson, Mona; Moraca, Federica; Catalanotti, Bruno; Fowler, Christopher J.; Onnis, Valentina | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors | 1-gen-2020 | Moi, Davide; Nocentini, Alessio; Deplano, Alessandro; Osman, Sameh M.; Alothman, Zeid A.; Piras, Valentina; Balboni, Gianfranco; Supuran, Claudiu T.; Onnis, Valentina | BIOORGANIC CHEMISTRY | - |
| The fatty acid amide hydrolase and cyclooxygenase-inhibitory properties of novel amide derivatives of carprofen | 1-gen-2020 | Deplano, Alessandro; Karlsson, Jessica; Fowler, Christopher J.; Onnis, Valentina | BIOORGANIC CHEMISTRY | - |
| Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors | 1-gen-2020 | Nocentini, Alessio; Moi, Davide; Deplano, Alessandro; Osman, Sameh M.; Alothman, Zeid A.; Balboni, Gianfranco; Supuran, Claudiu T.; Onnis, Valentina | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation | 1-gen-2019 | Moi, Davide; Nocentini, Alessio; Deplano, Alessandro; Balboni, Gianfranco; Supuran, Claudiu T.; Onnis, Valentina | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors | 1-gen-2019 | Moi, Davide; Foster, Paul A.; Rimmer, Lucy G.; Jaffri, Alisha; Deplano, Alessandro; Balboni, Gianfranco; Onnis, Valentina; Potter, Barry V. L. | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors | 1-gen-2019 | Deplano, Alessandro; Cipriano, Mariateresa; Moraca, Federica; Novellino, Ettore; Catalanotti, Bruno; Fowler, Christopher J.; Onnis, Valentina | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Onthe use (QM) IEF/PMC-MST-derived hydrophobic contributions as physicochemical descriptors in 3D-QSAR: the PHARMSQSARTM approach | 1-gen-2018 | Rey, Oscar; Ginex, Tiziana; Vazquez, Javier; Deplano, Alessandro; Herrero, Albert; Gibert, Enric; Herrero, Enric; Javier Luque, Francisco | - | - |
| Development and Validation of Molecular Overlays Derived from Three-Dimensional Hydrophobic Similarity with PharmScreen | 1-gen-2018 | Vázquez, J.; Deplano, A.; Herrero, A.; Ginex, T.; Gibert, E.; Rabal, O.; Oyarzabal, J.; Herrero, E.; Luque, F. J. | JOURNAL OF CHEMICAL INFORMATION AND MODELING | - |
| Hydrophobic similarity between molecules: Application to three-dimensional molecular overlays with PharmScreen | 1-gen-2018 | Vazquez, Javier; Deplano, Alessandro; Herrero, Albert; Gibert, Enric; Ginex, Tiziana; Rabal, Obdulia; Oyarzabal, Julen; Herrero, Enric; Luque, F Javier | - | American Chemical Society |
| Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions | 1-gen-2017 | Corona, Angela; Onnis, Valentina; Deplano, Alessandro; Bianco, Giulia; Demurtas, Monica; Distinto, Simona; Cheng, Yung Chi; Alcaro, Stefano; Esposito, Francesca; Tramontano, Enzo | PATHOGENS AND DISEASE | - |
| Novel propanamides as fatty acid amide hydrolase inhibitors | 1-gen-2017 | Deplano, Alessandro; Morgillo, Carmine Marco; Demurtas, Monica; Björklund, Emmelie; Cipriano, Mariateresa; Svensson, Mona; Hashemian, Sanaz; Smaldone, Giovanni; Pedone, Emilia; Luque, F. Javier; Cabiddu, MARIA GRAZIA; Novellino, Ettore; Fowler, Christopher J.; Catalanotti, Bruno; Onnis, Valentina | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Design, synthesis and SAR of small molecules acting on pain pathways | 24-mar-2016 | - | - | Università degli Studi di Cagliari |
| DIHYDROQUINAZOLINE BENZYLAMIDES AS ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORS | 1-gen-2016 | Onnis, Valentina; Balboni, Gianfranco; Deplano, Alessandro; Demurtas, Monica; Buyn, Joon Seok; Sohn, Joo Mi; Lee, Jae Yeol; Catto, Marco; Pisani, Leonardo; Carotti, Angelo | - | - |
| DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NEW DNA METHYLTRANSFERASE INHIBITORS | 1-gen-2016 | Balboni, Gianfranco; Deplano, Alessandro; Demurtas, Monica; Arimondo, Paola B.; Masson, Veronique; Onnis, Valentina | - | - |
| Discovery of a novel class of profen derivatives as FAAH inhibitors: MD and QM/MM studies of the binding mode and 3D SAR | 1-gen-2016 | Morgillo, Cm; Deplano, Alessandro; Karlsson, J; Cipriano, M; Björklund, E; Fowler, Cj; Onnis, Valentina; Luque, Fj; Catalanotti, B. | - | - |
| Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy | 1-gen-2016 | Costanzi, Stefano; Skorski, Matthew; Deplano, Alessandro; Habermehl, Brett; Mendoza, Mary; Wang, Keyun; Biederman, Michelle; Dawson, Jessica; Gaoa, Jia | JOURNAL OF MOLECULAR GRAPHICS & MODELLING | - |
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