Sfoglia per Autore
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold
2016-01-01 Distinto, Simona; Meleddu, Rita; Yanez, Matilde; Cirilli, Roberto; Bianco, Giulia; Sanna, MARIA LUISA; Arridu, Antonella; Cossu, Pietro; Cottiglia, Filippo; Faggi, Cristina; Ortuso, Francesco; Alcaro, Stefano; Maccioni, Elias
Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement
2016-01-01 Rocca, Roberta; Costa, Giosuè; Artese, Anna; Parrotta, Lucia; Ortuso, Francesco; Maccioni, Elias; Pinato, Odra; Greco, Maria Laura; Sissi, Claudia; Alcaro, Stefano; Distinto, Simona; Moraca, Federica
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase
2015-01-01 Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Francesca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias
Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations
2015-01-01 Rocca, R.; Moraca, F.; Costa, G.; Alcaro, S.; Distinto, Simona; Maccioni, Elias; Ortuso, F.; Artese, A.; Parrotta, L.
Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies
2015-01-01 Ruiu, S; Anzani, N; Orrù, A; Floris, Costantino; Caboni, Pierluigi; Alcaro, S; Maccioni, Elias; Distinto, Simona; Cottiglia, Filippo
Lactoferrin- and antitransferrin-modified liposomes for brain targeting of the NK3 receptor agonist senktide: Preparation and in vivo evaluation
2015-01-01 DE LUCA, MARIA ANTONIETTA; Lai, Francesco; Corrias, F; Caboni, Pierluigi; Bimpisidis, Z; Maccioni, Elias; Fadda, ANNA MARIA; Di Chiara, G.
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII
2015-01-01 Meleddu, Rita; Maccioni, Elias; Distinto, Simona; Bianco, Giulia; Melis, Claudia; Alcaro, Stefano; Cottiglia, Filippo; Ceruso, Mariangela; Supuran, Claudiu T.
Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) enlighten the mechanism of action of a new Ribonuclease H/DNA polymerase RT dual inhibitor
2014-01-01 Esposito, Francesca; Corona, Angela; Meleddu, Rita; Distinto, Simona; Giulia, Bianco; Maccioni, Elias; Stuart JF Le Grice, ; Enzo, Tramontano
Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase
2014-01-01 Meleddu, Rita; Cannas, Valeria; Distinto, Simona; Sarais, Giorgia; Del Vecchio, C; Esposito, Francesca; Bianco, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Artese, A; Scalise, D; Fresta, M; Arridu, A; Ortuso, F; Maccioni, Elias; Tramontano, Enzo
Design, Synthesis and Biological Evaluation of New 1,3-Diarylpropenones as Single Site Dual Inhibitors of HIV-1 RT
2013-01-01 Esposito, Francesca; Meleddu, R; Cannas, Valeria; Distinto, Simona; Del Vecchio, C; Bianco, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Maccioni, Elias; Tramontano, Enzo
N-alkylamides from Otanthus maritimus: structure elucidation, binding affinity for cannabinoid receptors and computational study
2013-01-01 Anzani, N.; Ruiu, S.; Orrù, A.; Floris, Costantino; Caboni, Pierluigi; Maccioni, Elias; Distinto, Simona; Alcaro, S.; Cottiglia, Filippo
Design, synthesis and biological activity evaluation of c-myc proto-oncogene binders as potential antitumor agents
2013-01-01 Meleddu, R.; Distinto, S; Sissi, C.; Musetti, C.; Arridu, A.; Bianco, Giulia; Parrotta, L.; Ortuso, F.; Alcaro, S.; Maccioni, Elias
Synthesis and biological activity evaluation of new dual-inhibitors of both associated functions of HIV-1 RT
2013-01-01 Meleddu, R.; Distinto, Simona; Corona, Angela; Bianco, Giulia; Arridu, A.; Cannas, V.; Tramontano, Enzo; Alcaro, S.; Matyus, P.; Maccioni, Elias
In search of new antitumor agents through the combination of individually active moieties: construction of a [3,5-diaryl-(4,5- dihydropyrazol-1-yl)-4-oxo-1,3-thiazol-5-ylidene]- 1H-indol-2-ones library
2013-01-01 Arridu, A.; Meleddu, R.; Bianco, Giulia; Distinto, Simona; Bogdan, D.; Matyus, P.; Maccioni, Elias
2-(2-cycloalkylidene hydrazin-1-yl)-4-aryl-1,3-thiazoles: a promising class of antifungal agents
2013-01-01 Arridu, A.; Meleddu, R.; Bianco, Giulia; Distinto, Simona; DE LOGU, Alessandro; Matyus, P.; Maccioni, Elias
MD protocol validation for the study of MAOB-inhibitor complexes
2013-01-01 Bianco, Giulia; Cossu, P.; Distinto, Simona; Meleddu, R.; Arridu, A.; Ortuso, F.; Alcaro, S.; Maccioni, Elias
Towards the total block of HIV-1 Reverse Transcriptase: the dual-inhibitors approach
2013-01-01 Meleddu, R.; Arridu, A.; Bianco, Giulia; Tramontano, Enzo; Distinto, Simona; Matyus, P.; Maccioni, Elias
Investigation on the mechanism of action of new dual inhibitors of HIV-1 RT
2013-01-01 Bianco, Giulia; Distinto, Simona; Meleddu, R.; Cannas, C.; Del Vecchio, C.; Cottiglia, Filippo; Alcaro, S.; Parolin, C.; Tramontano, Enzo; Maccioni, Elias
New dual inhibitors of RT associated functions: investigation on their mechanism and mode of action
2013-01-01 Distinto, Simona; Bianco, Giulia; Meleddu, R.; Cannas, C.; Del Vecchio, C.; Cottiglia, Filippo; Alcaro, S.; Parolin, C.; Tramontano, Enzo; Maccioni, Elias
Design, Synthesis and Biological Evaluation of New 1,3-Diarylpropenones as Dual Inhibitors of HIV-1 RT.
2013-01-01 Esposito, Francesca; Meleddu, R; Cannas, V; Distinto, Simona; Del Vecchio, C; Biano, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Maccioni, Elias; Tramontano, Enzo
| Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
|---|---|---|---|---|
| Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold | 1-gen-2016 | Distinto, Simona; Meleddu, Rita; Yanez, Matilde; Cirilli, Roberto; Bianco, Giulia; Sanna, MARIA LUISA; Arridu, Antonella; Cossu, Pietro; Cottiglia, Filippo; Faggi, Cristina; Ortuso, Francesco; Alcaro, Stefano; Maccioni, Elias | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement | 1-gen-2016 | Rocca, Roberta; Costa, Giosuè; Artese, Anna; Parrotta, Lucia; Ortuso, Francesco; Maccioni, Elias; Pinato, Odra; Greco, Maria Laura; Sissi, Claudia; Alcaro, Stefano; Distinto, Simona; Moraca, Federica | CHEMMEDCHEM | - |
| (3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase | 1-gen-2015 | Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Francesca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations | 1-gen-2015 | Rocca, R.; Moraca, F.; Costa, G.; Alcaro, S.; Distinto, Simona; Maccioni, Elias; Ortuso, F.; Artese, A.; Parrotta, L. | MOLECULES | - |
| Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies | 1-gen-2015 | Ruiu, S; Anzani, N; Orrù, A; Floris, Costantino; Caboni, Pierluigi; Alcaro, S; Maccioni, Elias; Distinto, Simona; Cottiglia, Filippo | JOURNAL OF NATURAL PRODUCTS | - |
| Lactoferrin- and antitransferrin-modified liposomes for brain targeting of the NK3 receptor agonist senktide: Preparation and in vivo evaluation | 1-gen-2015 | DE LUCA, MARIA ANTONIETTA; Lai, Francesco; Corrias, F; Caboni, Pierluigi; Bimpisidis, Z; Maccioni, Elias; Fadda, ANNA MARIA; Di Chiara, G. | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
| New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII | 1-gen-2015 | Meleddu, Rita; Maccioni, Elias; Distinto, Simona; Bianco, Giulia; Melis, Claudia; Alcaro, Stefano; Cottiglia, Filippo; Ceruso, Mariangela; Supuran, Claudiu T. | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) enlighten the mechanism of action of a new Ribonuclease H/DNA polymerase RT dual inhibitor | 1-gen-2014 | Esposito, Francesca; Corona, Angela; Meleddu, Rita; Distinto, Simona; Giulia, Bianco; Maccioni, Elias; Stuart JF Le Grice, ; Enzo, Tramontano | - | - |
| Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase | 1-gen-2014 | Meleddu, Rita; Cannas, Valeria; Distinto, Simona; Sarais, Giorgia; Del Vecchio, C; Esposito, Francesca; Bianco, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Artese, A; Scalise, D; Fresta, M; Arridu, A; Ortuso, F; Maccioni, Elias; Tramontano, Enzo | CHEMMEDCHEM | - |
| Design, Synthesis and Biological Evaluation of New 1,3-Diarylpropenones as Single Site Dual Inhibitors of HIV-1 RT | 1-gen-2013 | Esposito, Francesca; Meleddu, R; Cannas, Valeria; Distinto, Simona; Del Vecchio, C; Bianco, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Maccioni, Elias; Tramontano, Enzo | VIROLOGIE | - |
| N-alkylamides from Otanthus maritimus: structure elucidation, binding affinity for cannabinoid receptors and computational study | 1-gen-2013 | Anzani, N.; Ruiu, S.; Orrù, A.; Floris, Costantino; Caboni, Pierluigi; Maccioni, Elias; Distinto, Simona; Alcaro, S.; Cottiglia, Filippo | - | - |
| Design, synthesis and biological activity evaluation of c-myc proto-oncogene binders as potential antitumor agents | 1-gen-2013 | Meleddu, R.; Distinto, S; Sissi, C.; Musetti, C.; Arridu, A.; Bianco, Giulia; Parrotta, L.; Ortuso, F.; Alcaro, S.; Maccioni, Elias | - | - |
| Synthesis and biological activity evaluation of new dual-inhibitors of both associated functions of HIV-1 RT | 1-gen-2013 | Meleddu, R.; Distinto, Simona; Corona, Angela; Bianco, Giulia; Arridu, A.; Cannas, V.; Tramontano, Enzo; Alcaro, S.; Matyus, P.; Maccioni, Elias | - | - |
| In search of new antitumor agents through the combination of individually active moieties: construction of a [3,5-diaryl-(4,5- dihydropyrazol-1-yl)-4-oxo-1,3-thiazol-5-ylidene]- 1H-indol-2-ones library | 1-gen-2013 | Arridu, A.; Meleddu, R.; Bianco, Giulia; Distinto, Simona; Bogdan, D.; Matyus, P.; Maccioni, Elias | - | - |
| 2-(2-cycloalkylidene hydrazin-1-yl)-4-aryl-1,3-thiazoles: a promising class of antifungal agents | 1-gen-2013 | Arridu, A.; Meleddu, R.; Bianco, Giulia; Distinto, Simona; DE LOGU, Alessandro; Matyus, P.; Maccioni, Elias | - | - |
| MD protocol validation for the study of MAOB-inhibitor complexes | 1-gen-2013 | Bianco, Giulia; Cossu, P.; Distinto, Simona; Meleddu, R.; Arridu, A.; Ortuso, F.; Alcaro, S.; Maccioni, Elias | - | - |
| Towards the total block of HIV-1 Reverse Transcriptase: the dual-inhibitors approach | 1-gen-2013 | Meleddu, R.; Arridu, A.; Bianco, Giulia; Tramontano, Enzo; Distinto, Simona; Matyus, P.; Maccioni, Elias | - | - |
| Investigation on the mechanism of action of new dual inhibitors of HIV-1 RT | 1-gen-2013 | Bianco, Giulia; Distinto, Simona; Meleddu, R.; Cannas, C.; Del Vecchio, C.; Cottiglia, Filippo; Alcaro, S.; Parolin, C.; Tramontano, Enzo; Maccioni, Elias | - | - |
| New dual inhibitors of RT associated functions: investigation on their mechanism and mode of action | 1-gen-2013 | Distinto, Simona; Bianco, Giulia; Meleddu, R.; Cannas, C.; Del Vecchio, C.; Cottiglia, Filippo; Alcaro, S.; Parolin, C.; Tramontano, Enzo; Maccioni, Elias | - | - |
| Design, Synthesis and Biological Evaluation of New 1,3-Diarylpropenones as Dual Inhibitors of HIV-1 RT. | 1-gen-2013 | Esposito, Francesca; Meleddu, R; Cannas, V; Distinto, Simona; Del Vecchio, C; Biano, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Maccioni, Elias; Tramontano, Enzo | - | - |
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