Composite soy lecithin-decylpolyglucoside vesicles: A theoretical and experimental study

In the present work, vesicles made with soy lecithin and a commercial mixture of alkyl polyglucosides were prepared and characterized. Vesicles with a constant amount of soy lecithin and an increasing amount of a decylpolyglucoside surfactant, (OrNS10), were formulated and their physicochemical properties were studied with the airn to design a drug delivery system suitable for different applications. To this put-pose, morphology, size distribution, zeta-potential and apparent viscosity of the prepared vesicles were studied. Vesicles were also characterized by using optical and light polarized microscopy, transmission electron microscopy and photon correlation spectroscopy. A stability study was also performed by checking mean size and C-potential value variation of the several formulations during 4 weeks. Moreover, theoretical advances on geometric and thermodynamic aspects related to lipid vesicle formation were applied to this study. (c) 2007 Elsevier B.V. All rights reserved.