2-Triazenopyrroles were synthesized by coupling the corresponding 2-diazopyrroles with secondary amines and tested for antiproliferative, antifungal, antiviral and antibacterial activities. Derivative 9m was the most cytotoxic, showing, against leukaemia, lymphoma and carcinoma cell lines, IC50 3.9-21 mu M and inhibited Cox-B2 and VSV with EC50 10 mu M. Derivative 9j, instead, was active against C. albicans with a selectivity index higher than that of miconazole.
2-Triazenopyrroles: synthesis and biological activity
PANI, ALESSANDRA;
1999-01-01
Abstract
2-Triazenopyrroles were synthesized by coupling the corresponding 2-diazopyrroles with secondary amines and tested for antiproliferative, antifungal, antiviral and antibacterial activities. Derivative 9m was the most cytotoxic, showing, against leukaemia, lymphoma and carcinoma cell lines, IC50 3.9-21 mu M and inhibited Cox-B2 and VSV with EC50 10 mu M. Derivative 9j, instead, was active against C. albicans with a selectivity index higher than that of miconazole.
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