Rats were administered daily for 8 days with increasing doses (2-12 mg/kg/day) of delta9-tetrahydrocannabinol (delta9-THC) and than challenged with different doses of SR141716A, an antagonist of cannabinoid receptors. SR141716A dose dependently reduced dialysate dopamine (DA) in the nucleus accumbens shell and precipitated a physical withdrawal syndrome. No such effects were obtained after administration of SR141716A to saline controls

Dependence of mesolimbic dopamine transmission on Delta(9)-tetrahydrocannabinol

DI CHIARA, GAETANO
1999-01-01

Abstract

Rats were administered daily for 8 days with increasing doses (2-12 mg/kg/day) of delta9-tetrahydrocannabinol (delta9-THC) and than challenged with different doses of SR141716A, an antagonist of cannabinoid receptors. SR141716A dose dependently reduced dialysate dopamine (DA) in the nucleus accumbens shell and precipitated a physical withdrawal syndrome. No such effects were obtained after administration of SR141716A to saline controls
1999
Delta(9)-tetrahydrocannabinol, dopamine, microdialysis, nucleus accumbens, rat, SR141716A ; KeyWords Plus: CANNABINOID RECEPTOR ANTAGONIST, DRUG-ABUSE, WITHDRAWAL, ACTIVATION
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/36502
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