A copper-catalysed oxidative amidation of aldehydes via N-Hydroxysuccinimide ester formation is reported. The methodology, employed to prepare amides directly from aldehydes, has a very wide scope, with high yields and does not need dry conditions. This cross-coupling reaction appears simple and makes use of cheap, abundant and easily available reagents
A Copper-Catalysed Amidation of Aldehydes via N-Hydroxysuccinimide Ester Formation
PORCHEDDU, ANDREA;
2013-01-01
Abstract
A copper-catalysed oxidative amidation of aldehydes via N-Hydroxysuccinimide ester formation is reported. The methodology, employed to prepare amides directly from aldehydes, has a very wide scope, with high yields and does not need dry conditions. This cross-coupling reaction appears simple and makes use of cheap, abundant and easily available reagents
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