URINARY BENZENE IN BIOLOGICAL MONITORING OF ENVIRONMENTAL EXPOSURE TO LOW BENZENE CONCENTRATIONS. Introduction. Conflicting opinions exist about urinary benzene (UB) as a reliable biomarker of exposure. Objective of our study is to evaluate the effect of low-level environmental exposure on UB levels. Methods. We monitored UB excretion in 74 non-smoking non- occupationally exposed subjects; a questionnaire interview gathered information on relevant exposures during the day of monitoring. Results. UB excretion was related (p<0.05) to gender, sampling time, residence, and reported vehicular traffic, but not to passive smoking and body mass index. Conclusion: Our findings support the use of unmetabolized UB as a specific and sensitive biomarker of low-level exposure to benzene.
Il benzene urinario nel monitoraggio biologico dell’esposizione a bassi livelli ambientali
CAMPAGNA, MARCELLO;SATTA, GIANNINA;IBBA, ANTONIO;AVATANEO, GIUSEPPE;COCCO, PIER LUIGI
2011-01-01
Abstract
URINARY BENZENE IN BIOLOGICAL MONITORING OF ENVIRONMENTAL EXPOSURE TO LOW BENZENE CONCENTRATIONS. Introduction. Conflicting opinions exist about urinary benzene (UB) as a reliable biomarker of exposure. Objective of our study is to evaluate the effect of low-level environmental exposure on UB levels. Methods. We monitored UB excretion in 74 non-smoking non- occupationally exposed subjects; a questionnaire interview gathered information on relevant exposures during the day of monitoring. Results. UB excretion was related (p<0.05) to gender, sampling time, residence, and reported vehicular traffic, but not to passive smoking and body mass index. Conclusion: Our findings support the use of unmetabolized UB as a specific and sensitive biomarker of low-level exposure to benzene.
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