4-(2-Pyridinylamino)-1,1,1-trifluoro-3-penten-2-ones 3, obtained from the reaction of commercially available 2-aminopyridine derivatives and 4-methoxy-1,1,1-trifluoro-3-penten-2-one 2, were converted to 6-(dimethylamino)-4-(2-pyridinylamino)-3,5-hexadien-2-ones 4 by treatment with dimethylformamide dimethyl acetal. Azannulation of hexadienones 4 afforded 4-(2-pyridinylamino)-2 -trifluoromethylpyridines 5 and 2-(trifluoroacetyl methylene)pyrido[1,2 -a] pyrimidines 6, classes of compounds particularly interesting fro m a chemical and biological point of view.

Synthesis and azannulation of pyridinylaminohexadienones.

CONGIU, CENZO;ONNIS, VALENTINA
2001-01-01

Abstract

4-(2-Pyridinylamino)-1,1,1-trifluoro-3-penten-2-ones 3, obtained from the reaction of commercially available 2-aminopyridine derivatives and 4-methoxy-1,1,1-trifluoro-3-penten-2-one 2, were converted to 6-(dimethylamino)-4-(2-pyridinylamino)-3,5-hexadien-2-ones 4 by treatment with dimethylformamide dimethyl acetal. Azannulation of hexadienones 4 afforded 4-(2-pyridinylamino)-2 -trifluoromethylpyridines 5 and 2-(trifluoroacetyl methylene)pyrido[1,2 -a] pyrimidines 6, classes of compounds particularly interesting fro m a chemical and biological point of view.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/95719
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