1,5-Disubstituted pyrimidine-2,4-diones were synthesized by fusion of 5-bromouracil with an aniline derivative followed by coupling with benzyl halide whereas the opposite synthesis sequence failed. Also 4,6-dichloro-N,N,5-trimethylpyrimidin-2-amine was treated with phenols. The products were tested for their activity against HIV-1.
Synthesis and anti-HIV-1 evaluation of 1,5-disubstituted pyrimidine-2,4-diones
COLLU, GABRIELLA;LODDO, ROBERTA
2008-01-01
Abstract
1,5-Disubstituted pyrimidine-2,4-diones were synthesized by fusion of 5-bromouracil with an aniline derivative followed by coupling with benzyl halide whereas the opposite synthesis sequence failed. Also 4,6-dichloro-N,N,5-trimethylpyrimidin-2-amine was treated with phenols. The products were tested for their activity against HIV-1.
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