2026-09-23T19:15:47Zhttps://iris.unica.it/oai/requestoai:iris.unica.it:11584/2662272022-10-20T09:33:44Zcom_11584_207615com_11584_111066col_11584_265854
Innovatives liposomes for overcoming biological barriers
CHESSA, MAURA
Liposomi promotori dell'assorbimento
curcumin
curcumina
ficocianina
liposomes penetration enhancer
phycocyanin
quercetin
quercetina
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes loading quercetin and phycocyanin are designed for a topical application and were tested on new born pig skin. Liposomes and chitosomes loading curcumin are designed for pulmonary delivery as a cure for cystic fibrosis. In this case, has been tested the toxicity of the system using a model of lung tissue using Calu-3 cells.
The drug delivery via liposomes and chitosomes improves the retention time of the drug and increases its stability. Studies continue with biocompatibility and in vivo tests.
2013-04-11
info:eu-repo/semantics/doctoralThesis
http://hdl.handle.net/11584/266227
eng
numberofpages:91
info:eu-repo/semantics/openAccess
Università degli Studi di Cagliari
license:Non specificato