2026-09-23T05:57:23Zhttps://iris.unica.it/oai/request

oai:iris.unica.it:11584/2663542022-10-20T09:38:49Zcom_11584_207615com_11584_111066col_11584_265854

Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα MELIS, MIRIAM acetylcholine dopamine electrophysiology neuron peroxisome proliferator-activated receptor ventral tegmental area Settore BIO/14 - Farmacologia SPECIFIC AIMS OF THE STUDY 1) To investigate whether FAEs can suppress nicotine-induced stimulation of VTA dopamine (DA) neuron firing rate through the peroxisome-proliferator-activated receptor-α (PPARα) and to elucidate their mechanism of action in an in vitro brain slice preparation. 2) To determine whether there is an interaction between PPARα and nAChRs in VTA DA cells: particularly, to characterize the postsynaptic effects of PPARα modulation on VTA DA neurons, and to examine the contribution of nAChRs in the effects. 3) To study whether PPARα modulation of nAChRs in VTA DA neurons might confer DA cells to access distinct firing patterns and/or to change their firing frequency both in vivo and in vitro. 4) To examine the physiological relevance of PPARα modulation of nAChR stimulation through behavioral analysis. 2011-01-27 info:eu-repo/semantics/doctoralThesis http://hdl.handle.net/11584/266354 ita numberofpages:101 info:eu-repo/semantics/openAccess Università degli Studi di Cagliari license:Non specificato