2026-09-18T18:02:34Zhttps://iris.unica.it/oai/requestoai:iris.unica.it:11584/2668042022-10-20T08:53:07Zcom_11584_207615com_11584_111066col_11584_265854
Markers immunoistochimici delle cellule staminali/progenitrici nel rene umano in via di sviluppo.
SANNA, ALICE
cellule staminali
kidney
rene
stem progenitor cells
Settore ING-IND/24 - Principi di Ingegneria Chimica
The aim of this study was to better define, by immunohistochemistry, the molecular markers of
renal stem/progenitor cells localized in the different niches of ten human preterm kidneys with
gestational age ranging from 11 up to 25 weeks. Our data evidence the existence of multiple
stem/progenitor pools in different zones of the human developing kidney that are characterized by
different phenotypes: capsular stem cells were EMA (MUC1)+, MDM2+, Vimentin+ and Wnt1+;
progenitors of the sub-capsular nephrogenic zone were MDM2+ and Wnt1+; cap mesenchymal
cells were EMA (MUC1)+, CD15+, vimentin+, Wt1+, CD10+, Bcl2+, Wnt1+ and PAX2+;
interstitial progenitor cells were Vimentin+, Wt1+ and α1Anti-tripsin +. Our data evidence the
existence of multiple stem/progenitor cell pools in the fetal and neonatal human kidney. Progenitors
of these different pools are characterized by a peculiar phenotype, indicating a different
differentiation stage of these renal progenitors. A better knowledge of the molecular markers
expressed by renal stem/progenitors might represent a relevant datum for researchers involved in
renal regenerative medicine.
2015-05-25
info:eu-repo/semantics/doctoralThesis
http://hdl.handle.net/11584/266804
ita
numberofpages:43
info:eu-repo/semantics/openAccess
Università degli Studi di Cagliari
license:Non specificato