2026-09-23T10:40:35Zhttps://iris.unica.it/oai/requestoai:iris.unica.it:11584/3596982023-04-26T11:41:13Zcom_11584_207615com_11584_111066col_11584_207612
Innovative Apatite/Bioactive Glass-based materials for biomedical applications
ANGIONI, DAMIANO
ORRU', ROBERTO
Settore ING-IND/22 - Scienza e Tecnologia dei Materiali
Musculoskeletal-related problems are nowadays one of the main concerns in healthcare, due
to tumors, traumatology, osteoporosis and others pathologies, especially considering ageing
populations. These diseases and induced defects affect millions of people worldwide. An
important scientific effort was dedicated, in the past decades, to the development of bonegrafts
materials as alternatives to allo- and autografts, due to the drawbacks associated with
the employment of the latter ones (as for instance, transmission complications as well as immunological
rejection and morbidity).
Scientific research focused on synthetic bone graft displaying suitable properties is an actual
hot topic. In this context, calcium phosphates (in particular hydroxyapatite) and bioactive
glasses, recently gained much attention due to their characteristics as promising materials
for the treatment of non-self-healing bone defects. Indeed, they display biocompatibility,
good bioactivity and non-toxicity. Despite these, clinical application of hydroxyapatite- and
bioactive glass-derived materials is still limited, and further development of such materials is
needed.
The main aim of this work is then to contribute to solve some of the drawbacks displayed by
these classes of materials (related to their composition, synthesis and manufacturing), to provide
possible useful insights about howto limit/overcome them. In the present thesis, beyond
the state of the art, it was attempted to tackle various problems related to the development of
innovative materials for hard tissue engineering.
2023-04-21T00:00:00+02:00
info:eu-repo/semantics/doctoralThesis
https://hdl.handle.net/11584/359698
eng
info:eu-repo/semantics/openAccess
Università degli Studi di Cagliari