2026-09-23T13:00:53Zhttps://iris.unica.it/oai/requestoai:iris.unica.it:11584/3597022023-04-26T12:11:02Zcom_11584_207615com_11584_111066col_11584_207612
Virtual Reality Frontiers in Bipolar Disorders: A Recovery Oriented
Cognitive Rehabilitation tool.
PERRA, ALESSANDRA
CARTA, MAURO
Settore MED/50 - Scienze Tecniche Mediche Applicate
Background: Cognitive impairment is a fundamental rehabilitation outcome for people with
mental disorders. This represents a barrier to achieve clinical, personal and social outcomes
essential for a good quality of life. In line with the WHO innovation objective are increasing
the use of technologies for treatment of mental disorders. This study aims at evaluating the
feasibility and preliminary effectiveness of the first Cognitive Remediation Virtual Reality
Program for people with bipolar disorder.
Methods: Feasibility randomized controlled cross-over clinical study; we randomized 50
people from the Consultation and Psychosomatic Psychiatry Center of the University
Hospital of Cagliari with a diagnosis of bipolar disorder. We proposed a CR/VR recoveryoriented
program, 3 months with 2 weekly sessions, for the experimental group and a usual
care program for the control group (psychiatric visit and/or psychotherapy).
Results: We observed a significant feasibility outcome and clinical outcomes, both cognitive
and personal and social functioning. In particular in memory (Ray’s Word Test p<0.003),
attention (Matrix Test p<0.002), verbal fluency (FAS Test p<0.010), executive function in
terms of cognitive esteem function (CET p<0.003), depressive symptoms (PHQ-9 p< 0.030),
alexithymia (TAS-20 p<0.007) and in biological rhythms (BRIAN è<0.029).
Conclusion: This RCT aims, with regards to it feasibility and design, to inform a
confirmatory trial that evaluates the effectiveness of a VR CR program in psychiatric
rehabilitation for the treatment of cognitive dysfunction in people with bipolar disorder. The
results could have an impact on psychiatric rehabilitation research with a focus on
improving the application of technologies for mental health.
2023-04-21T00:00:00+02:00
info:eu-repo/semantics/doctoralThesis
https://hdl.handle.net/11584/359702
eng
info:eu-repo/semantics/openAccess
Università degli Studi di Cagliari