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[(re)-14.8(a)13(c)-14.8(t)11.4(i).6(on)4.7(s)-338(o)4.7(ver)-333.1(both)-330.5(t).6(he)-332.9(s)-14.8(h)16.6(ort)-334.5(a)-14.8(n)15.4(d)-336.8(medium/long)-330.5(te)-14.8(r)12.8(m)-334(\(Corte)-14.8(s)14.2(e)-332.9(e)-14.8(t)-323.8(al.)]TJ
T*
-.0155 Tc
[(2013\).)-252.4(T)-2.2(he)-257.7(mos)-15.5(t)-241(common)-249(o)-2.4(f)-251.6(t)-.1(hes)-15.5(e)-239.4(include)-251.4(los)-15.5(s)-238.2(of)-251.6(appetite)-15.5(,)-241.6(r)1.4(es)-15.5(t)11.9(r)1.4(i)-15.5(c)10.7(te)-15.5(d)]TJ
0 -1.2266 TD
-.0151 Tc
[(growth,)-346.8(a)-15.1(n)15.1(d)-349.7(w)-15.1(e)11.8(ight)-347.4(s)3.2(uppres)-15.1(s)8.8(i).3(o)4.4(n)-349.7(\()-15.1(F)10(ara)-15.1(o)15.1(ne)-352.1(et)-353.7(al.)-353.1(2)-2(0)-15.1(0)4.8(8)-15.1(\))2.2(,)-346.8(i)-15.1(nc)-15.1(re)-15.1(a)6.3(s)-15.1(es)-344.6(i)-15.1(n)]TJ
0 -1.2203 TD
0 Tc
[(bl)15.9(o)13.1(o)0(d)-251.9(p)0(r)17.3(e)0(s)16.3(s)0(u)18.8(r)0(e)-250.6(a)0(n)17.5(d)-265.1(h)13.1(e)0(a)15.1(r)0(t)-252.2(r)0(a)14.9(t)0(e)-252.1(\()0(G)20.4(r)0(a)14.9(h)13.1(am)-251.6(an)17.5(d)-265.1(C)0(o)21.5(g)0(h)13.6(i)0(l)18.2(l)-256.4(20)19.9(08)13.6(;)-256.4(H)0(a)14.2(m)0(m)19.2(e)0(r)14.9(-)]TJ
T*
[(ne)17.5(ss)-387.1(et)-391.2(al)19.8(.)-394.9(2)0(0)13.6(1)13.1(1\))17.3(,)-394.9(s)0(l)14.7(e)0(e)15.1(p)-397.9(d)13.1(i)0(s)14.7(t)0(u)22.2(r)0(b)17.3(a)0(n)17.5(c)0(e)15.1(s)-399(\(S)18.8(ch)17.5(ac)15.1(h)13.1(t)0(e)13.5(r)-394.1(et)-391.2(al)19.8(.)-394.9(2)0(0)13.6(0)13.1(1\))17.3(,)-394.9(and)]TJ
0 -1.2266 TD
[(po)19.9(ss)17.6(ib)15.9(le)-157.2(ex)17.5(ac)15.1(er)14.9(b)13.1(a)0(t)13.5(i)0(o)15.9(n)-163.9(of)-153.4(ex)17.5(is)14.7(ti)18.2(ng)-157.1(ti)18.2(cs)-160.7(\(P)18.8(ri)19.6(ng)13.6(sh)18.8(ei)19.8(m)-167.4(a)0(n)17.5(d)-163.9(St)17.3(ee)15.1(ve)17.5(s)-165.1(2)0(0)19.9(1)0(1)13.6(\))0(.)]TJ
1.1128 -1.2203 TD
[(Short-term)-274.7(po)19.9(si)14.7(t)15.4(i)0(v)15.9(e)-267.5(ef)21.2(fe)14.9(ct)19.8(s)-266.3(o)13.1(f)-267.7(M)12.4(PH)-260.1(o)13.1(n)-265.1(co)17.5(gn)19.9(it)18.2(io)22.2(n)-265.1(a)0(n)17.5(d)-265.1(mo)16.4(ti)18.2(v)13.1(a)0(t)19.8(i)0(o)15.9(n)]TJ
-1.1128 -1.2203 TD
[(ar)21.2(e)-330.7(w)0(e)20.5(l)0(l)-316.9(d)13.1(oc)17.5(u)13.1(m)0(e)14(n)13.1(te)19.8(d)-328.3(i)0(n)-312.9(n)0(e)17.5(u)13.1(ro)17.3(p)13.1(s)0(y)18.8(c)0(h)17.5(o)13.1(lo)15.9(g)13.1(i)0(c)19.8(a)0(l)-321.6(s)0(t)21.1(u)13.1(di)15.9(es)-312.4(\(V)20.4(ol)15.9(k)13.1(o)0(w)-318.5(e)0(t)-315.3(a)0(l)19.8(.)]TJ
0 -1.2266 TD
[(20)19.9(04)19.9(;)-218.5(C)0(o)15.2(g)13.1(hi)15.9(l)15.4(l)-224.8(et)-207.8(al)13.5(.)-217.9(2)13.1(01)19.9(4\))17.3(.)-217.9(S)0(t)17.3(i)0(m)18.7(u)13.1(la)13.5(n)13.1(t)-218.5(me)14(d)13.1(i)0(c)19.8(a)0(t)19.8(i)0(o)15.9(n)-220.8(ma)20.3(y)-220.8(i)0(m)18.7(p)13.1(ro)17.3(v)13.1(e)-223.2(so)18.8(me)]TJ
0 -1.2203 TD
[(co)17.5(g)13.1(n)0(i)15.9(t)0(i)24.6(v)0(e)-279.6(f)0(u)17.3(n)13.1(ct)13.5(i)15.4(o)0(n)19.9(s)-291.6(\(a)21.2(tt)18.2(en)17.5(ti)18.2(o)13.1(n)0(\))17.3(,)-287.4(b)13.1(u)0(t)-281.3(t)0(h)22.3(e)0(r)21.2(e)-292.8(ar)21.2(e)-292.8(a)0(l)19.8(s)0(o)-278.4(r)0(e)21.2(p)0(o)19.9(r)0(t)19.6(s)-291.5(t)15.4(h)0(a)17.5(t)-288.1(it)-278.9(im)18.7(-)]TJ
T*
[(pa)17.5(ir)19.6(s)-285.2(o)0(t)15.9(h)13.1(er)21.2(s)-291.5(s)0(u)18.8(c)0(h)-273.3(a)0(s)-280.8(d)13.1(iv)15.9(er)21.2(ge)17.5(n)13.1(t)-288.1(th)15.9(i)15.4(n)0(k)19.9(i)0(n)15.9(g)-284(\(D)20.4(ou)19.9(gl)15.9(as)-274.5(et)-277.3(al)13.5(.)-287.4(1)13.1(99)19.9(5)13.1(\))0(,)-283.2()14.6(ex)17.5(i-)]TJ
T*
[(bi)22.2(li)18.2(ty)-211.7(an)17.5(d)-220.8(p)0(l)15.9(a)0(n)23.9(n)0(i)15.9(n)13.1(g)-227.1(\()0(A)20.4(d)13.1(vo)19.9(ca)15.1(t)-218.5(2)0(0)19.9(1)0(0)19.9(\))0(,)-213.7(o)0(r)-210.3(c)0(r)14.9(e)0(a)21.4(t)0(i)18.2(v)0(i)22.2(t)0(y)-218(\()0(F)25.1(a)0(r)14.9(a)0(h)-210.1(e)0(t)-214.1(a)0(l)19.8(.)-224.2(20)19.9(0)13.1(8)0(\))17.3(,)]TJ
0 -1.2266 TD
[(at)-233.1(le)19.8(as)22.7(t)-243.8(i)0(n)-224.3(s)0(o)18.8(m)0(e)-232.6(c)0(a)21.4(s)0(e)16.3(s)0(.)-231.2(I)0(n)-229.2(t)0(e)19.8(r)0(m)20.1(s)-241(o)13.1(f)-242.4(ad)23.9(ve)17.5(rs)16.2(e)-235.9(e)0(v)17.5(e)0(n)17.5(t)0(s)21.1(,)-236.9(la)13.5(b)13.1(o)0(r)17.3(a)0(t)19.8(o)13.1(ry)-229.3(st)14.7(u)13.1(d)0(i)22.2(e)0(s)]TJ
0 -1.2203 TD
[(pr)17.3(o)13.1(v)0(i)15.9(d)13.1(e)-267.5(s)0(o)18.8(m)0(e)-251.6(e)0(v)17.5(i)0(d)22.2(e)0(n)17.5(c)0(e)-256.8(o)0(f)-254.5(c)0(o)17.5(g)13.1(ni)15.9(ti)18.2(v)13.1(e)-267.5(ri)19.6(g)13.1(i)0(d)15.9(i)0(t)24.6(y)-265.1(\(S)18.8(ol)15.9(an)23.9(to)-256(19)19.9(84)19.9(\),)-257.9(re)21.3(wa)20.5(rd)]TJ
T*
[(de)17.5(se)22.7(ns)18.8(it)18.2(iz)19.8(at)19.8(io)15.9(n)-214.5(\()0(A)14(n)13.1(de)17.5(rs)22.5(en)-210.1(et)-214.1(al)19.8(.)-217.9(2)13.1(00)19.9(8\))17.3(,)-217.9(a)0(l)19.8(t)0(e)19.8(r)0(e)14.9(d)-220.8(at)19.8(tr)19.6(ib)22.2(ut)22.2(io)15.9(n)-220.8(s)0(t)21.1(y)13.1(le)19.8(/s)14.7(en)23.9(se)]TJ
0 -1.2266 TD
[(of)-279.8(ag)17.5(en)17.5(cy)-279.6(\(C)18.9(ar)21.2(ls)21.1(on)-283.6(et)-277.3(al)13.5(.)-287.4(1)13.1(99)19.9(3\))17.3(,)-287.4(a)0(n)17.5(d)0(/)15.9(o)13.1(r)-293(i)15.4(mp)16.4(ai)19.8(re)21.3(d)-290.4(m)0(e)14(m)0(o)22.7(r)0(y)-279.8(\()0(S)18.8(p)13.1(ra)14.9(g)13.1(u)0(e)]TJ
0 -1.2203 TD
[(et)-346.9(al)13.5(.)-357(1)13.1(97)19.9(7\))-349.4(wi)18.9(th)-344.5(so)18.8(me)-352.7(o)13.1(f)-356.2(th)15.9(es)22.7(e)-362.3(c)0(o)23.9(g)0(n)19.9(i)0(t)18.2(i)0(v)15.9(e)-356(ch)17.5(an)23.9(ge)17.5(s)-361.1(b)13.1(ei)19.8(ng)-346.8(do)19.9(se)-350.4(de)17.5(-)]TJ
T*
[(pe)17.5(n)13.1(d)0(e)17.5(n)0(t)-142.1(s)0(u)18.8(c)0(h)-146.9(t)0(h)22.2(a)0(t)-150.9(h)13.1(ig)15.9(h)13.1(e)0(r)-143.1(d)0(o)19.9(s)0(e)16.3(s)-152.4(le)13.5(ad)-140.5(to)-148.5(mo)22.7(re)-149.5(im)25(pa)17.5(ir)19.6(in)15.9(g)-151.3(a)0(d)17.5(v)13.1(er)14.9(se)-141.7(ev)17.5(en)17.5(ts)21.1(.)]TJ
1.1128 -1.2267 TD
[(Con)15.7(sis)14(ten)14(t)-224.8(wit)15.4(h)-227.1(thi)12.4(s)-222(not)16.4(ion)16.4(,)-230.5(the)14(re)-219(are)-214.6(als)12.8(o)-227.1(rep)15.4(ort)13.8(s)-222(i)0(n)-224.3(the)-213.6(lit)14.7(era)13(tur)13.8(e)]TJ
-1.1128 -1.2203 TD
[(of)-292.5(high)16.9(er)-294.9(dos)12.9(es)-293.5(of)-298.8(MP)14.3(H)-300(bei)14(ng)-296.2(mor)14.3(e)-299.1(eff)12.8(ect)11.6(ive)-289.5(for)-288.3(beha)16.1(vio)16.4(ral)-292.1(man)14.5(-)]TJ
T*
[(age)15.6(men)14.5(t)-401.9(but)-388.3(imp)12.9(act)11.6(ing)-388.3(nega)16.1(tiv)18.7(ely)-390.7(on)-397.4(exe)15.6(cut)14(ive)-390.7(att)16.3(ent)14(ion)-394.6(con)18(tro)13.8(l)]TJ
T*
[(and)-241.2(wor)14.5(kin)16.4(g)-246.1(mem)17.3(ory)-241.4(\(B)12.6(err)12.8(idg)16.4(e)-248.5(e)0(t)-245.7(al.)-236(200)14.1(6\).)-238.5(Th)13.8(us,)-237.1(if)-245.9(cli)16.3(nic)14(ian)14(s)-247.3(and)]TJ
0 -1.2266 TD
[(fam)11.9(ili)14.7(es)-363(pri)13.8(ori)13.8(tiz)16.3(e)-375(beh)18(avi)14(ora)15.4(l)-370.3(tar)11.4(get)14(s)-367.4(i)0(n)-363.4(tre)11.4(atm)16.8(ent)-359.1(goal)14.5(s,)-364(thi)18.7(s)-373.7(may)]TJ
0 -1.2203 TD
[(lim)15.2(it)-278.9(the)-276.9(po)13.6(ten)14(tial)-271.8(imp)12.9(act)-273(of)-279.8(MPH)-273(on)-283.6(aca)13.2(dem)14.5(ic)-277.3(ach)15.6(iev)14(eme)12.1(nt)-281.2(mor)14.3(e)]TJ
T*
[(gene)16.1(ral)17.7(ly,)-170.4(giv)16.4(en)-172.2(the)-169.4(low)13.1(er)-174.8(do)13.6(ses)-174(req)15.4(uir)13.8(ed)-172.2(for)-168.1(cogn)18.5(iti)14.7(ve)-172.2(enha)16.1(nce)15.6(men)14.5(t)]TJ
0 -1.2266 TD
[(\(c.)12(f.)13.9(,)-432.9(Hal)17(e)-431.9(e)0(t)-422.8(al.)-419.4(20)13.6(11\).)-415(Fina)15.9(lly)18.7(,)-432.9(the)14(re)-421.4(have)-413.9(als)12.8(o)-429.5(bee)15.6(n)-429.5(rep)15.4(ort)13.8(s)-430.7(o)0(f)]TJ
0 -1.2203 TD
[(adve)16.1(rse)-257.7(em)14(oti)12.4(onal)-251.1(eve)15.6(nts)-256.7(\(e.)12(g.,)-251.9(Pelh)15.9(am)-257.9(and)-260.2(Hoz)14.7(a)-267.5(1)0(9)13.6(96\),)-250.7(whi)13.1(ch)-260.7(are)]TJ
T*
[(kno)14.1(wn)-185.7(to)-186.4(pla)14(y)-195.5(a)-191.6(rol)13.8(e)-191.6(i)0(n)-186.4(both)-179.1(cogn)18.5(iti)14.7(ve)-184.8(abi)14(lit)14.7(y)-195.5(and)-184.3(mot)19.2(iva)14(tio)12.4(nal)-182(sty)15.2(le.)]TJ
1.1128 -1.2266 TD
[(While)-313.4(there)-312.5(are)-309.5(some)-315(reports)-312.9(that)-312(adverse)-317.4(events)-310.6(of)-311.4(MPH)-310.9(may)]TJ
-1.1128 -1.2203 TD
[(manifest)-256.6(as)-249.2(changes)-251.6(in)-249.6(cognition)-250.4(and)-253.9(motivation,)-254(these)-247.9(may)-257.4(not)-249.2(be)]TJ
T*
[(mentioned)-283.9(or)-286.2(questioned)-281.1(in)-287.6(the)-283.2(course)-283.9(of)-279.8(routine)-287.9(clinical)-285(practice.)]TJ
0 -1.2266 TD
[(Regulatory)-457.9(bodies)-453.6(like)-451.1(the)-453.9(European)-458.6(Medicines)-455.4(Agency)-454.1(\(EMA)]TJ
0 -1.2203 TD
[(2010\))-272.1(require)-276.2(the)-276.9(monitoring)-272.6(and)-272.8(collection)-277.7(of)-273.5(pharmacovigilance)]TJ
T*
[(data,)-427.1(which)-424.6(involves)-425.1(the)-422.3(monitoring)-424.3(of)-425.3(medication)-429(effects)-425.2(after)]TJ
T*
[(licensing)-235(for)-237.7(adverse)-235.3(effects)-235.5(not)-236.5(reported)-237.8(or)-229.2(found)-234.1(in)-237(clinical)-234.4(trials.)]TJ
0 -1.2266 TD
[(These)-243.7(data)-240.8(are)-239.9(required)-244.1(to)-243.3(be)-235.4(collated)-243(for)-244(potential)-244.2(adverse)-241.6(effects/)]TJ
0 -1.2203 TD
[(events)-215.8(during)-212.4(the)-213.6(clinical)-215.4(development)-209.5(of)-216.6(psychotropic)-213.1(compounds)]TJ
T*
[(and)-317.1(through)-319.4(postmarketing)-315.1(surveillance)-323.2(for)-313.6(up)-315.2(to)-319.2(2)-315.7(years)-316(in)-319.2(adult)]TJ
0 -1.2266 TD
[(and)-272.8(pediatric)-276.8(populations.)-272.5(However,)-279.1(it)-272.6(is)-269.8(not)-274.4(well)-271(understood)-277.2(how)]TJ
27.9978 56.2297 TD
[(consistently)-346.2(cognitive)-335(adverse)-342.7(events)-342.2(are)-334.8(reported)-345.3(once)-338(the)-340.1(regu-)]TJ
0 -1.2203 TD
[(latory)-503.3(monitoring)-500.2(and)-494.1(reporting)-498.1(period)-499.3(for)-503.3(the)-498.2(medication)-498.5(has)]TJ
T*
[(ended)-350.2(\(post-2)-348.4(years)-347.6(for)-345.2(ADHD)-352.7(medication\))-348.9(as)-344.1(it)-348.5(depends)-350.4(on)-346.8(cli-)]TJ
0 -1.2266 TD
[(nicians)-282.5(and)-272.8(patients)-279.7(spontaneously)-280.8(identifying)-275(and)-279.2(reporting)-276.8(these)]TJ
0 -1.2203 TD
[(as)-186(adverse)-184.7(events)-177.8(or)-185(side)-182.7(effects)-185(\(e.g.,)-176.7(through)-180.2(yellow)-187.9(card)-182.5(reporting)]TJ
T*
[(in)-281.3(the)-283.2(UK-MHRA)-283.4(2015\).)]TJ
1.1128 -1.2267 TD
[(While)-433.6(typical)-437.1(acute)-432.5(adverse)-437.6(effect)-430.9(scales)-440.7(for)-427.4(stimulant)-436.1(treat-)]TJ
-1.1128 -1.2203 TD
[(ments)-615.7(such)-615(as)-615.9(the)-618.3(Safety)-614.1(Monitoring)-611.2(Uniform)-619.7(Report)-611.5(Form)]TJ
T*
[(\(SMURF;)-249.4(Greenhill)-252.4(et)-252.1(al.)-248.6(2004\))-246.8(or)-241.9(the)-251.6(Side)-249.7(Effects)-251.9(Scale)-247.7(\(Barkley)]TJ
0 -1.2266 TD
[(et)-220.4(al.)-223.4(1990\))-215.1(collate)-224.6(information)-220.2(such)-216.6(as)-223.9()54.8(stares)-221.7(a)-216.9(lot,)57.9()-223.4()54.8(talks)-220(less,)57.7()]TJ
0 -1.2203 TD
[()54.8(prone)-200.7(to)-192.7(crying,)52.1()-198.1()54.8(anxious,)58.2()-198.1(o)0(r)-197.6()61.1(sadness,)51.1()-198.1(detailed)-198.8(standardized)]TJ
T*
[(assessments)-420(of)-412.6(potential)-414.9(adverse)-418.6(events)-418.1(of)-412.6(MPH)-412.1(across)-417.9(broader)]TJ
T*
[(psychological)-336.6(domainsfor)-333(instance,)-331.6(those)-334(relating)-331.7(to)-331.8(cognition,)]TJ
0 -1.2266 TD
[(motivation,)-235.1(and)-228.6(moodare)-234.2(still)-229.8(lacking.)-233.7(Nevertheless,)-231.7(this)-228.6(may)-232.1(be)]TJ
0 -1.2203 TD
[(of)-381(particular)-380(importance)-377(as)-382(it)-373.8(has)-381.5(been)-375.9(suggested)-379.9(that)-375.2(cognitive,)]TJ
T*
[(motivational,)-265.8(and)-266.5(emotional)-262.6(adverse)-266.9(events)-266.4(are)-265.2(signicant)-264.7(reasons)]TJ
0 -1.2266 TD
[(for)-313.6(lack)-304.1(of)-311.5(adherence)-307.5(with,)-309.5(or)-305.1(discontinuation)-309.7(of,)-308(long-term)-312(med-)]TJ
0 -1.2203 TD
[(ication)-329.6(use,)-327.5(particularly)-332.5(during)-326.2(adolescence)-330.5(\(Charach)-329.4(et)-327.9(al.)-324.5(2004,)]TJ
T*
(2008\).)Tj
1.1128 -1.2266 TD
[(The)-386.5(lack)-386.3(of)-387.3(routine)-389(monitoring)-380(of)-387.3(cognitive)-385.6(and)-386.7(motivational)]TJ
-1.1128 -1.2203 TD
[(adverse)-355.4(events)-354.9(in)-350.8(everyday)-353.7(clinical)-354.5(practice)-357.8(could)-351.8(be)-349.2(linked)-355.3(to)-350.8(a)]TJ
T*
[(more)-259.5(general)-263.4(lack)-259.8(of)-254.5(systematic)-260.6(monitoring)-259.9(of)-254.5(treatment)-261.3(response,)]TJ
T*
[(as)-356.7(many)-351.8(clinicians)-354.8(still)-349.9(rely)-354.9(on)-346.8(spontaneous)-353.6(reporting)-352.7(of)-355.7(adverse)]TJ
0 -1.2266 TD
[(events)-399.1(by)-397.4(patients)-393.6(and)-399.3(parents)-394.9(\(Kovshoff)-399.9(et)-397.5(al.)-394.1(2012\).)-395.1(It)-397.7(is)-396.2(also)]TJ
0 -1.2203 TD
[(likely)-188.6(due)-184.3(to)-186.4(the)-188.3(fact)-186.5(that)-185.6(compared)-186.5(to)-186.4(other)-190(elements)-186.8(of)-185(the)-188.3(putative)]TJ
T*
[(MPH)-355.2(adverse)-355.4(event)-354.2(or)-355.7(effect)-355(prole,)-355.4(the)-352.7(concept)-355.6(of)-349.4(cognitive)-353.9(or)]TJ
0 -1.2266 TD
[(motivational)-364.1(adverse)-361.7(events)-367.5(remains)-360.5(both)-356.2(poorly)-364.1(dened)-360.9(and)-361.4(ar-)]TJ
0 -1.2203 TD
[(ticulated,)-287.4(with)-281.3(no)-277.2(standardized)-287.5(approach)-277.8(to)-281.3(reporting)-283.2(available.)]TJ
1.1128 -1.2203 TD
[(Other)-351.3(potential)-351.6(reasons)-354.2(for)-351.5(the)-346.4(lack)-354.7(of)-349.4(focus)-351.5(on)-346.8(cognitive)-353.9(and)]TJ
-1.1128 -1.2266 TD
[(motivational)-458.9(adverse)-456.6(events)-456(include)-452.1(that)-457.4(\(i\))-450.4(they)-453.4(may)-453.4(be)-456.7(more)]TJ
0 -1.2203 TD
[(difcult)-302.6(to)-293.9(observe)-302.4(than)-295.3(typical)-304.3(adverse)-298.5(events;)-301.5(\(ii\))-295.8(they)-295.3(might)-300(be)]TJ
T*
[(experienced)-367.4(as)-363(subtle)-356.5(and/or)-360.2(vague)-362.8(signs)-364.4(that)-356.3(are)-366.4(difcult)-359.5(to)-357.1(de-)]TJ
0 -1.2266 TD
[(scribe)-338.5(and)-336.1(self-report,)-338.2(particularly)-338.8(by)-327.8(younger)-336.7(children;)-337.6(\(iii\))-337.3(they)]TJ
0 -1.2203 TD
[(may)-225.8(be)-216.4(rare;)-226.6(\(iv\))-215.9(it)-222(may)-219.5(be)-222.7(difcult)-220.4(to)-218(establish)-223.5(a)-223.2(causal)-224.5(link)-214.7(\(if)-222.7(one)]TJ
T*
[(exists\))-448.3(between)-453.8(these)-443.9(adverse)-450.2(events)-449.7(and)-449.9(the)-441.2(medication,)-450.8(or)-444.2(to)]TJ
T*
[(differentiate)-368.7(between)-358.9(concerns)-361.2(specic)-361.7(to)-357.1(MPH)-361.5(and)-355(core)-359.6(or)-362(sec-)]TJ
0 -1.2266 TD
[(ondary)-292.9(symptoms)-294.1(of)-292.5(the)-295.8(ADHD)-295.8(itself;)-290.8(or)-292.5(\(v\))-294.6(the)-289.5(benets)-296.1(of)-292.5(MPH)]TJ
0 -1.2203 TD
[(experienced)-203(by)-188.7(the)-194.7(patient)-196.8(and)-190.6(families)-197.4(may)-194.2(outweigh)-193.2(any)-190.6(potential)]TJ
T*
[(cognitive)-328.7(or)-317.8(motivational)-326.1(adverse)-317.4(events)-323.3(experienced,)-326.1(and)-323.4(hence,)]TJ
0 -1.2266 TD
[(these)-298.5(adverse)-298.5(events)-298(may)-295.3(not)-293.4(be)-292.3(seen)-294.9(as)-299.8(sufciently)-292.1(signicant)-296.3(to)]TJ
0 -1.2203 TD
[(warrant)-285.8(reporting.)]TJ
1.1128 -1.2203 TD
.0116 Tc
[(T)11.6(h)11.6(e)-431.8(current)-434.5(a)-3(rticle)-439.3(represents)-444.3(the)-439.3().9(rst)-440.9(s)-1.7(tage)-439.3(i)-4.6(n)-436.8(a)-439.3(p)-.6(ro)11.6(j)-10.4(e)3.3(ct)-440.9(to)]TJ
-1.1128 -1.2267 TD
.0113 Tc
[(i)-4.9(n)-.9(v)11.3(e)-9.1(stigat)-4.9(e)-313.1(c)-3.3(ognitive)-319.4(a)3.1(nd)-317(mot)-4.9(i)1.4(vati)-4.9(o)11.3(n)-6.7(al)-314.7(adv)11.3(e)-9.1(rse)-319.4(e)-3.3(v)11.3(e)-9.1(nts)-318.2(f)2.9(oll)-4.9(o)11.3(w)-10(i)1.4(ng)]TJ
0 -1.2203 TD
.0118 Tc
[(stimulan)11.8(t)-218.9(m)2.4(edication)-209(u)-.4(se)-211.4(as)-210.2(part)-213(of)-205.3(th)11.8(e)-217.3(E)-.2(uro)11.8(p)-6.2(ean)-215.3(C)1.2(o)11.8(m)-9.7(mission)-209(7)-.4(th)]TJ
T*
.0145 Tc
[(Fr)6.1(am)5.1(e)6.2(w)-1(or)6.1(k)-332.8(P)3.8(rog)14.5(r)-6.1(am)5.1(m)5.1(e)-335.2(fo)14.5(r)-341.2(r)-.3(e)6.2(s)1.2(ea)6.3(rc)]TJ
14.6249 0 TD
.011 Tc
[(h;)-340.3(Attention)-336.3(D)-4.5(ecit/)-5.2(h)11(y)-7(perac-)]TJ
-14.6249 -1.2203 TD
.0117 Tc
[(tivity)-228.1(Drugs)-222.9(Us)4.7(e)-230.5(C)1.1(hronic)-230.5(E)-.3(ffects)]TJ
13.6385 0 TD
[(\(ADDUCE;)-225.8(www.adhd-addu)11.7(c)-8.7(e)3.5(.)]TJ
-13.6385 -1.2267 TD
.0123 Tc
[(org)12.3(G)-8.5(r)3.9(ant)-617.2(n).1(o)12.3(.)-628.7(2)12.3(6)-5.7(0576)12.3(\))-627.9(\()-78.3(Murray)-619.5(et)-617.2(al.)-616.6(2)12.3(0)-5.7(13;)-617.2(Inglis)-614.4(et)-617.2(al.)]TJ
/F3 1 Tf
-27.9978 77.0953 TD
0 Tc
(538)Tj
45.5439 0 TD
[(KOVSHOFF)-335(ET)-338.7(AL.)]TJ
ET
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