CORONA, ANGELA
CORONA, ANGELA
DIPARTIMENTO DI SCIENZE DELLA VITA E DELL'AMBIENTE
2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition
2026-01-01 Cernicchi, Giada; Nizi, Maria Giulia; Emmolo, Roberta; Persoons, Leentje; Laporte, Manon; Jochmans, Dirk; Romeo, Isabella; Pepe, Giacomo; Milite, Ciro; Campiglia, Pietro; Spezzini, Jacopo; Martelli, Alma; Brogi, Simone; Esposito, Francesca; Felicetti, Tommaso; Massari, Serena; Manfroni, Giuseppe; Sabatini, Stefano; Sbardella, Gianluca; Alcaro, Stefano; Neyts, Johan; Corona, Angela; Tramontano, Enzo; De Jonghe, Steven; Tabarrini, Oriana
A combination of MD-derived pharmacophores and structure-based strategy identifies dual allosteric inhibitors of NS2B-NS3 proteases in Zika and West Nile viruses
2026-01-01 Lupia, Antonio; Nieddu, Salvatore; Demuru, Laura; Sanna, Erica; Onali, Alessia; Emmolo, Roberta; Malune, Paolo; Distinto, Simona; Atzeni, Giulia; Paulis, Annalaura; Meleddu, Rita; Cottiglia, Filippo; Esposito, Francesca; Corona, Angela; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo
Cyclization-Inspired Structural Optimization: Designing Potent Non-nucleoside Reverse Transcriptase Inhibitors with Enhanced Safety and Selectivity
2026-01-01 Zhang, Y. -X.; Pannecouque, C.; Clercq, E. D.; Tramontano, E.; Corona, A.; Dettori, L.; Tran, P. -T.; Li, X. -D.; Su, S.; Wang, S.; Chen, F. -E.
Exploring the Pyrimidine Scaffold for the Development of SARSCoV‑2 Mpro Inhibitors
2026-01-01 Nieddu, Salvatore; Ruggieri, G.; De Santis, R.; Malune, Paolo.; Patacchini, E.; Noemi Madia, V.; Saccoliti, F.; Essore, A.; Zarbo, A.; Corona, Angela; Amatore, A.; Grilli, G.; Amoroso, A.; Lista, F.; Tramontano, Enzo; Costi, R.; Di Santo, R.; Esposito, Francesca
Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2
2026-01-01 Maloccu, Stefania; Otsuka, Yuka; Molchan, Elizabeth; Foti, Michelle; Paulis, Annalaura; Vishwakarma, Jyoti; Malune, Paolo; Cottiglia, Filippo; Corona, Angela; Scampavia, Louis; Spicer, Timothy P.; Harris, Reuben S.; Tramontano, Enzo; Fanunza, Elisa
Infectious Diseases Research in the Global South: Treatments and Treatment Failures
2026-01-01 Wicht, Kathryn; Ganesan, Sandhya; Corona, Angela; Matange, Nishad
Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
2026-01-01 Zhang, Kun; Zhao, Li-Min; Xing, Tianhao; Bu, Yueyue; Wang, Qingyun; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Structure-based virtual screening leads to the discovery of a 4,5-dihydropyrazole derivative as the first dual inhibitor of West Nile virus NS3 helicase and protease
2026-01-01 Lupia, Antonio; Emmolo, Roberta; Atzeni, Giulia; Sanna, Erica; Nieddu, Salvatore; Onali, Alessia; Demuru, Laura; Paulis, Annalaura; Distinto, Simona; Corona, Angela; Esposito, Francesca; Meleddu, Rita; Cottiglia, Filippo; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo
Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity
2025-01-01 Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap
Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors
2025-01-01 Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er
Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability
2025-01-01 Zhang, K.; Xing, T.; Ding, L.; Pannecouque, C.; De Clercq, E.; Corona, A.; Dettori, L.; Tramontano, E.; Wang, S.; Chen, F. -E.
Dual-Site Inhibition of SARS-CoV2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach
2025-01-01 Malune, Paolo; Iaconis, Daniela; Manelfi, Candida; Giunta, Stefano; Emmolo, Roberta; Lunghini, Filippo; Paulis, Annalaura; Talarico, Carmine; Corona, Angela; Rosario Beccari, Andrea; Tramontano, Enzo; Esposito, Francesca
Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases
2025-01-01 Tu, Nhat Quang; Richetta, Clémence; Putzu, Federica; Delelis, Olivier; Ahmed, Khursheed; Masand, Vijay H.; Schobert, Rainer; Tramontano, Enzo; Corona, Angela; Biersack, Bernhard
Identifying potential allosteric inhibitors of ZIKV NS3pro through a combined computational and biochemical approach
2025-01-01 Demuru, L.; Lupia, A.; Nieddu, S.; Emmolo, R.; Paulis, A.; Esposito, F.; Distinto, S.; Bryant, S. D.; Onali, A.; Sanna, E.; Atzeni, G.; Cottiglia, F.; Grandi, N.; Corona, A.; Tramontano, E.; Maccioni, E.; Meleddu, R.
Meeting report: Seventh summer school on innovative approaches for identification of antiviral agents (IAAASS)
2025-01-01 Corona, Angela; Cagno, Valeria; Grandi, Nicole; Fanunza, Elisa; Esposito, Francesca; Seley-Radtke, Kathie L.; Tramontano, Enzo
N -alkyl and N-benzyl indoles are anti-SARS-CoV-2 agents and nsp13 inhibitors
2025-01-01 Albano, Aurora; Emmolo, Roberta; De Santis, Riccardo; Patacchini, Elisa; Madia, Valentina Noemi; Maloccu, Stefania; Ialongo, Davide; Ruggieri, Giuseppe; Arpacioglu, Merve; Scipione, Luigi; Saccoliti, Francesco; Amatore, Donatella; Grilli, Giorgia; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta
Structure-Based Discovery of Novel Diarylpyrimidines as Potent and Selective Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-Biphenyl-Diarylpyrimidines to C=NNH2-Biphenyl-Diarylpyrimidines
2025-01-01 Chen, Xiao-Mei; Pannecouque, Christophe; De Clercq, Erik; Lian, Yu-Xuan; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors
2025-01-01 Madia, Valentina Noemi; Emmolo, Roberta; Patacchini, Elisa; Amatore, Donatella; Maloccu, Stefania; Ialongo, Davide; Albano, Aurora; Ruggieri, Giuseppe; Cara, Emanuele; Zarbo, Laura; Messore, Antonella; De Santis, Riccardo; Amoroso, Alessandra; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta
Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases
2025-01-01 Onali, A.; Sanna, E.; Lupia, A.; Secci, D.; Atzeni, G.; Demuru, L.; Angeli, A.; Cottiglia, F.; Meleddu, R.; Emmolo, R.; Corona, A.; Maccioni, E.; Supuran, C. T.; Distinto, S.
The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors
2025-01-01 Zian, D.; Iaconis, D.; Nenci, S.; Crusco, A.; Tawde, S.; Sodano, M.; Vitalone, R.; Raje, A.; Palamini, M.; Carettoni, D.; Molteni, A.; Manelfi, C.; Tazzari, V.; Beccari, A. R.; Malune, P.; Maloccu, S.; Paulis, Annalaura; Corona, Angela; Nieddu, Salvatore; Coletti, S.; Scarabottolo, L.; Tramontano, Enzo; Esposito, Francesca; Catalani, M.
| Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
|---|---|---|---|---|
| 2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition | 1-gen-2026 | Cernicchi, Giada; Nizi, Maria Giulia; Emmolo, Roberta; Persoons, Leentje; Laporte, Manon; Jochmans, Dirk; Romeo, Isabella; Pepe, Giacomo; Milite, Ciro; Campiglia, Pietro; Spezzini, Jacopo; Martelli, Alma; Brogi, Simone; Esposito, Francesca; Felicetti, Tommaso; Massari, Serena; Manfroni, Giuseppe; Sabatini, Stefano; Sbardella, Gianluca; Alcaro, Stefano; Neyts, Johan; Corona, Angela; Tramontano, Enzo; De Jonghe, Steven; Tabarrini, Oriana | CHEMMEDCHEM | - |
| A combination of MD-derived pharmacophores and structure-based strategy identifies dual allosteric inhibitors of NS2B-NS3 proteases in Zika and West Nile viruses | 1-gen-2026 | Lupia, Antonio; Nieddu, Salvatore; Demuru, Laura; Sanna, Erica; Onali, Alessia; Emmolo, Roberta; Malune, Paolo; Distinto, Simona; Atzeni, Giulia; Paulis, Annalaura; Meleddu, Rita; Cottiglia, Filippo; Esposito, Francesca; Corona, Angela; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Cyclization-Inspired Structural Optimization: Designing Potent Non-nucleoside Reverse Transcriptase Inhibitors with Enhanced Safety and Selectivity | 1-gen-2026 | Zhang, Y. -X.; Pannecouque, C.; Clercq, E. D.; Tramontano, E.; Corona, A.; Dettori, L.; Tran, P. -T.; Li, X. -D.; Su, S.; Wang, S.; Chen, F. -E. | JOURNAL OF MEDICINAL CHEMISTRY | - |
| Exploring the Pyrimidine Scaffold for the Development of SARSCoV‑2 Mpro Inhibitors | 1-gen-2026 | Nieddu, Salvatore; Ruggieri, G.; De Santis, R.; Malune, Paolo.; Patacchini, E.; Noemi Madia, V.; Saccoliti, F.; Essore, A.; Zarbo, A.; Corona, Angela; Amatore, A.; Grilli, G.; Amoroso, A.; Lista, F.; Tramontano, Enzo; Costi, R.; Di Santo, R.; Esposito, Francesca | ACS INFECTIOUS DISEASES | - |
| Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2 | 1-gen-2026 | Maloccu, Stefania; Otsuka, Yuka; Molchan, Elizabeth; Foti, Michelle; Paulis, Annalaura; Vishwakarma, Jyoti; Malune, Paolo; Cottiglia, Filippo; Corona, Angela; Scampavia, Louis; Spicer, Timothy P.; Harris, Reuben S.; Tramontano, Enzo; Fanunza, Elisa | ANTIVIRAL RESEARCH | - |
| Infectious Diseases Research in the Global South: Treatments and Treatment Failures | 1-gen-2026 | Wicht, Kathryn; Ganesan, Sandhya; Corona, Angela; Matange, Nishad | ACS INFECTIOUS DISEASES | - |
| Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors | 1-gen-2026 | Zhang, Kun; Zhao, Li-Min; Xing, Tianhao; Bu, Yueyue; Wang, Qingyun; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | CHINESE CHEMICAL LETTERS | - |
| Structure-based virtual screening leads to the discovery of a 4,5-dihydropyrazole derivative as the first dual inhibitor of West Nile virus NS3 helicase and protease | 1-gen-2026 | Lupia, Antonio; Emmolo, Roberta; Atzeni, Giulia; Sanna, Erica; Nieddu, Salvatore; Onali, Alessia; Demuru, Laura; Paulis, Annalaura; Distinto, Simona; Corona, Angela; Esposito, Francesca; Meleddu, Rita; Cottiglia, Filippo; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity | 1-gen-2025 | Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap | BIOORGANIC CHEMISTRY | - |
| Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors | 1-gen-2025 | Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er | MOLECULES | - |
| Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability | 1-gen-2025 | Zhang, K.; Xing, T.; Ding, L.; Pannecouque, C.; De Clercq, E.; Corona, A.; Dettori, L.; Tramontano, E.; Wang, S.; Chen, F. -E. | JOURNAL OF MEDICINAL CHEMISTRY | - |
| Dual-Site Inhibition of SARS-CoV2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach | 1-gen-2025 | Malune, Paolo; Iaconis, Daniela; Manelfi, Candida; Giunta, Stefano; Emmolo, Roberta; Lunghini, Filippo; Paulis, Annalaura; Talarico, Carmine; Corona, Angela; Rosario Beccari, Andrea; Tramontano, Enzo; Esposito, Francesca | ACS INFECTIOUS DISEASES | - |
| Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases | 1-gen-2025 | Tu, Nhat Quang; Richetta, Clémence; Putzu, Federica; Delelis, Olivier; Ahmed, Khursheed; Masand, Vijay H.; Schobert, Rainer; Tramontano, Enzo; Corona, Angela; Biersack, Bernhard | MOLECULES | - |
| Identifying potential allosteric inhibitors of ZIKV NS3pro through a combined computational and biochemical approach | 1-gen-2025 | Demuru, L.; Lupia, A.; Nieddu, S.; Emmolo, R.; Paulis, A.; Esposito, F.; Distinto, S.; Bryant, S. D.; Onali, A.; Sanna, E.; Atzeni, G.; Cottiglia, F.; Grandi, N.; Corona, A.; Tramontano, E.; Maccioni, E.; Meleddu, R. | - | - |
| Meeting report: Seventh summer school on innovative approaches for identification of antiviral agents (IAAASS) | 1-gen-2025 | Corona, Angela; Cagno, Valeria; Grandi, Nicole; Fanunza, Elisa; Esposito, Francesca; Seley-Radtke, Kathie L.; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| N -alkyl and N-benzyl indoles are anti-SARS-CoV-2 agents and nsp13 inhibitors | 1-gen-2025 | Albano, Aurora; Emmolo, Roberta; De Santis, Riccardo; Patacchini, Elisa; Madia, Valentina Noemi; Maloccu, Stefania; Ialongo, Davide; Ruggieri, Giuseppe; Arpacioglu, Merve; Scipione, Luigi; Saccoliti, Francesco; Amatore, Donatella; Grilli, Giorgia; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Structure-Based Discovery of Novel Diarylpyrimidines as Potent and Selective Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-Biphenyl-Diarylpyrimidines to C=NNH2-Biphenyl-Diarylpyrimidines | 1-gen-2025 | Chen, Xiao-Mei; Pannecouque, Christophe; De Clercq, Erik; Lian, Yu-Xuan; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors | 1-gen-2025 | Madia, Valentina Noemi; Emmolo, Roberta; Patacchini, Elisa; Amatore, Donatella; Maloccu, Stefania; Ialongo, Davide; Albano, Aurora; Ruggieri, Giuseppe; Cara, Emanuele; Zarbo, Laura; Messore, Antonella; De Santis, Riccardo; Amoroso, Alessandra; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta | CHEMMEDCHEM | - |
| Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases | 1-gen-2025 | Onali, A.; Sanna, E.; Lupia, A.; Secci, D.; Atzeni, G.; Demuru, L.; Angeli, A.; Cottiglia, F.; Meleddu, R.; Emmolo, R.; Corona, A.; Maccioni, E.; Supuran, C. T.; Distinto, S. | ACS MEDICINAL CHEMISTRY LETTERS | - |
| The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors | 1-gen-2025 | Zian, D.; Iaconis, D.; Nenci, S.; Crusco, A.; Tawde, S.; Sodano, M.; Vitalone, R.; Raje, A.; Palamini, M.; Carettoni, D.; Molteni, A.; Manelfi, C.; Tazzari, V.; Beccari, A. R.; Malune, P.; Maloccu, S.; Paulis, Annalaura; Corona, Angela; Nieddu, Salvatore; Coletti, S.; Scarabottolo, L.; Tramontano, Enzo; Esposito, Francesca; Catalani, M. | ANTIVIRAL RESEARCH | - |