CORONA, ANGELA
CORONA, ANGELA
DIPARTIMENTO DI SCIENZE DELLA VITA E DELL'AMBIENTE
Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity
2025-01-01 Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap
Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors
2025-01-01 Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er
Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases
2025-01-01 Tu, Nhat Quang; Richetta, Clémence; Putzu, Federica; Delelis, Olivier; Ahmed, Khursheed; Masand, Vijay H.; Schobert, Rainer; Tramontano, Enzo; Corona, Angela; Biersack, Bernhard
Meeting report: Seventh summer school on innovative approaches for identification of antiviral agents (IAAASS)
2025-01-01 Corona, Angela; Cagno, Valeria; Grandi, Nicole; Fanunza, Elisa; Esposito, Francesca; Seley-Radtke, Kathie L.; Tramontano, Enzo
Structure-Based Discovery of Novel Diarylpyrimidines as Potent and Selective Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-Biphenyl-Diarylpyrimidines to C=NNH2-Biphenyl-Diarylpyrimidines
2025-01-01 Chen, Xiao-Mei; Pannecouque, Christophe; De Clercq, Erik; Lian, Yu-Xuan; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors
2025-01-01 Madia, Valentina Noemi; Emmolo, Roberta; Patacchini, Elisa; Amatore, Donatella; Maloccu, Stefania; Ialongo, Davide; Albano, Aurora; Ruggieri, Giuseppe; Cara, Emanuele; Zarbo, Laura; Messore, Antonella; De Santis, Riccardo; Amoroso, Alessandra; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta
The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors
2025-01-01 Zian, D.; Iaconis, D.; Nenci, S.; Crusco, A.; Tawde, S.; Sodano, M.; Vitalone, R.; Raje, A.; Palamini, M.; Carettoni, D.; Molteni, A.; Manelfi, C.; Tazzari, V.; Beccari, A. R.; Malune, P.; Maloccu, S.; Paulis, Annalaura; Corona, Angela; Nieddu, Salvatore; Coletti, S.; Scarabottolo, L.; Tramontano, Enzo; Esposito, Francesca; Catalani, M.
Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2
2025-01-01 Kuzikov, Maria; Morasso, Stefano; Reinshagen, Jeanette; Wolf, Markus; Monaco, Vittoria; Cozzolino, Flora; Golič Grdadolnik, Simona; Šket, Primož; Plavec, Janez; Iaconis, Daniela; Summa, Vincenzo; Corona, Angela; Paulis, Annalaura; Esposito, Francesca; Tramontano, Enzo; Monti, Maria; Beccari, Andrea R.; Manelfi, Candida; Windshügel, Björn; Gribbon, Philip; Storici, Paola; Zaliani, Andrea
Call for Papers: Infectious Diseases Research in the Global South: Treatments and Treatment Failures
2024-01-01 Corona, Angela; Ganesan, Sandhya; Matange, Nishad; Wicht, Kathryn
Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors
2024-01-01 Zhao, K. -X.; Zhang, Y. -Y.; Wang, J. -S.; Wang, S.; Corona, A.; Maloccu, S.; Tramontano, E.; Pannecouque, C.; De Clercq, E.; Meng, G.; Wang, L.; Chen, F. -E.
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex
2024-01-01 Kuzikov, Maria; Reinshagen, Jeanette; Wycisk, Krzysztof; Corona, Angela; Esposito, Francesca; Malune, Paolo; Manelfi, Candida; Iaconis, Daniela; Beccari, Andrea; Tramontano, Enzo; Nowotny, Marcin; Windshügel, Bjorn; Gribbon, Philip; Zaliani, Andrea
Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines
2024-01-01 Huang, Wen-Juan; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Maloccu, Stefania; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity
2024-01-01 Paulis, A.; Onali, A.; Vidalain, P. O.; Lotteau, V.; Jaquemin, C.; Corona, A.; Distinto, S.; Delogu, G. L.; Tramontano, E.
New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors
2024-01-01 Messore, Antonella; Malune, Paolo; Patacchini, Elisa; Noemi Madia, Valentina; Ialongo, Davide; Arpacioglu, Merve; Albano, Aurora; Ruggieri, Giuseppe; Saccoliti, Francesco; Scipione, Luigi; Tramontano, Enzo; Canton, Serena; Corona, Angela; Scognamiglio, Sante; Paulis, Annalaura; Suleiman, Mustapha; Mohammed Al-Maqtari, Helmi; Abid, Fatma Mohamed A.; Kawsar, Sarkar M. A.; Sankaranarayanan, Murugesan; Di Santo, Roberto; Esposito, Francesca; Roberta Costi, And
Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy
2024-01-01 Zhu, X. -D.; Corona, A.; Maloccu, S.; Tramontano, E.; Wang, S.; Pannecouque, C.; De Clercq, E.; Meng, G.; Chen, F. -E.
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action
2023-01-01 Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E.
Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication
2023-01-01 Asthana, A.; Corona, A.; Shin, W. -J.; Kwak, M. -J.; Gaughan, C.; Tramontano, E.; Jung, J. U.; Schobert, R.; Jha, B. K.; Silverman, R. H.; Biersack, B.
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination
2023-01-01 Stefanelli, Irina; Corona, Angela; Cerchia, Carmen; Cassese, Emilia; Improta, Salvatore; Costanzi, Elisa; Pelliccia, Sveva; Morasso, Stefano; Esposito, Francesca; Paulis, Annalaura; Scognamiglio, Sante; Di Leva, Francesco Saverio; Storici, Paola; Brindisi, Margherita; Tramontano, Enzo; Cannalire, Rolando; Summa, Vincenzo
DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action
2023-01-01 Iaconis, Daniela; Caccuri, Francesca; Manelfi, Candida; Talarico, Carmine; Bugatti, Antonella; Filippini, Federica; Zani, Alberto; Novelli, Rubina; Kuzikov, Maria; Ellinger, Bernhard; Gribbon, Philip; Riecken, Kristoffer; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Beccari, Andrea Rosario; Caruso, Arnaldo; Allegretti, Marcello
Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication
2023-01-01 Corona, Angela; Madia, Valentina Noemi; De Santis, Riccardo; Manelfi, Candida; Emmolo, Roberta; Ialongo, Davide; Patacchini, Elisa; Messore, Antonella; Amatore, Donatella; Faggioni, Giovanni; Artico, Marco; Iaconis, Daniela; Talarico, Carmine; Di Santo, Roberto; Lista, Florigio; Costi, Roberta; Tramontano, Enzo
| Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
|---|---|---|---|---|
| Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity | 1-gen-2025 | Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap | BIOORGANIC CHEMISTRY | - |
| Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors | 1-gen-2025 | Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er | MOLECULES | - |
| Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases | 1-gen-2025 | Tu, Nhat Quang; Richetta, Clémence; Putzu, Federica; Delelis, Olivier; Ahmed, Khursheed; Masand, Vijay H.; Schobert, Rainer; Tramontano, Enzo; Corona, Angela; Biersack, Bernhard | MOLECULES | - |
| Meeting report: Seventh summer school on innovative approaches for identification of antiviral agents (IAAASS) | 1-gen-2025 | Corona, Angela; Cagno, Valeria; Grandi, Nicole; Fanunza, Elisa; Esposito, Francesca; Seley-Radtke, Kathie L.; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| Structure-Based Discovery of Novel Diarylpyrimidines as Potent and Selective Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-Biphenyl-Diarylpyrimidines to C=NNH2-Biphenyl-Diarylpyrimidines | 1-gen-2025 | Chen, Xiao-Mei; Pannecouque, Christophe; De Clercq, Erik; Lian, Yu-Xuan; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors | 1-gen-2025 | Madia, Valentina Noemi; Emmolo, Roberta; Patacchini, Elisa; Amatore, Donatella; Maloccu, Stefania; Ialongo, Davide; Albano, Aurora; Ruggieri, Giuseppe; Cara, Emanuele; Zarbo, Laura; Messore, Antonella; De Santis, Riccardo; Amoroso, Alessandra; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta | CHEMMEDCHEM | - |
| The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors | 1-gen-2025 | Zian, D.; Iaconis, D.; Nenci, S.; Crusco, A.; Tawde, S.; Sodano, M.; Vitalone, R.; Raje, A.; Palamini, M.; Carettoni, D.; Molteni, A.; Manelfi, C.; Tazzari, V.; Beccari, A. R.; Malune, P.; Maloccu, S.; Paulis, Annalaura; Corona, Angela; Nieddu, Salvatore; Coletti, S.; Scarabottolo, L.; Tramontano, Enzo; Esposito, Francesca; Catalani, M. | ANTIVIRAL RESEARCH | - |
| Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2 | 1-gen-2025 | Kuzikov, Maria; Morasso, Stefano; Reinshagen, Jeanette; Wolf, Markus; Monaco, Vittoria; Cozzolino, Flora; Golič Grdadolnik, Simona; Šket, Primož; Plavec, Janez; Iaconis, Daniela; Summa, Vincenzo; Corona, Angela; Paulis, Annalaura; Esposito, Francesca; Tramontano, Enzo; Monti, Maria; Beccari, Andrea R.; Manelfi, Candida; Windshügel, Björn; Gribbon, Philip; Storici, Paola; Zaliani, Andrea | ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | - |
| Call for Papers: Infectious Diseases Research in the Global South: Treatments and Treatment Failures | 1-gen-2024 | Corona, Angela; Ganesan, Sandhya; Matange, Nishad; Wicht, Kathryn | ACS INFECTIOUS DISEASES | - |
| Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors | 1-gen-2024 | Zhao, K. -X.; Zhang, Y. -Y.; Wang, J. -S.; Wang, S.; Corona, A.; Maloccu, S.; Tramontano, E.; Pannecouque, C.; De Clercq, E.; Meng, G.; Wang, L.; Chen, F. -E. | BIOORGANIC CHEMISTRY | - |
| Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex | 1-gen-2024 | Kuzikov, Maria; Reinshagen, Jeanette; Wycisk, Krzysztof; Corona, Angela; Esposito, Francesca; Malune, Paolo; Manelfi, Candida; Iaconis, Daniela; Beccari, Andrea; Tramontano, Enzo; Nowotny, Marcin; Windshügel, Bjorn; Gribbon, Philip; Zaliani, Andrea | VIRUS RESEARCH | - |
| Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines | 1-gen-2024 | Huang, Wen-Juan; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Maloccu, Stefania; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | JOURNAL OF MEDICINAL CHEMISTRY | - |
| Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity | 1-gen-2024 | Paulis, A.; Onali, A.; Vidalain, P. O.; Lotteau, V.; Jaquemin, C.; Corona, A.; Distinto, S.; Delogu, G. L.; Tramontano, E. | VIRUS RESEARCH | - |
| New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors | 1-gen-2024 | Messore, Antonella; Malune, Paolo; Patacchini, Elisa; Noemi Madia, Valentina; Ialongo, Davide; Arpacioglu, Merve; Albano, Aurora; Ruggieri, Giuseppe; Saccoliti, Francesco; Scipione, Luigi; Tramontano, Enzo; Canton, Serena; Corona, Angela; Scognamiglio, Sante; Paulis, Annalaura; Suleiman, Mustapha; Mohammed Al-Maqtari, Helmi; Abid, Fatma Mohamed A.; Kawsar, Sarkar M. A.; Sankaranarayanan, Murugesan; Di Santo, Roberto; Esposito, Francesca; Roberta Costi, And | PHARMACEUTICALS | - |
| Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy | 1-gen-2024 | Zhu, X. -D.; Corona, A.; Maloccu, S.; Tramontano, E.; Wang, S.; Pannecouque, C.; De Clercq, E.; Meng, G.; Chen, F. -E. | MOLECULES | - |
| 5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action | 1-gen-2023 | Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E. | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | - |
| Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication | 1-gen-2023 | Asthana, A.; Corona, A.; Shin, W. -J.; Kwak, M. -J.; Gaughan, C.; Tramontano, E.; Jung, J. U.; Schobert, R.; Jha, B. K.; Silverman, R. H.; Biersack, B. | VIRUSES | - |
| Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination | 1-gen-2023 | Stefanelli, Irina; Corona, Angela; Cerchia, Carmen; Cassese, Emilia; Improta, Salvatore; Costanzi, Elisa; Pelliccia, Sveva; Morasso, Stefano; Esposito, Francesca; Paulis, Annalaura; Scognamiglio, Sante; Di Leva, Francesco Saverio; Storici, Paola; Brindisi, Margherita; Tramontano, Enzo; Cannalire, Rolando; Summa, Vincenzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action | 1-gen-2023 | Iaconis, Daniela; Caccuri, Francesca; Manelfi, Candida; Talarico, Carmine; Bugatti, Antonella; Filippini, Federica; Zani, Alberto; Novelli, Rubina; Kuzikov, Maria; Ellinger, Bernhard; Gribbon, Philip; Riecken, Kristoffer; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Beccari, Andrea Rosario; Caruso, Arnaldo; Allegretti, Marcello | VIRUSES | - |
| Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication | 1-gen-2023 | Corona, Angela; Madia, Valentina Noemi; De Santis, Riccardo; Manelfi, Candida; Emmolo, Roberta; Ialongo, Davide; Patacchini, Elisa; Messore, Antonella; Amatore, Donatella; Faggioni, Giovanni; Artico, Marco; Iaconis, Daniela; Talarico, Carmine; Di Santo, Roberto; Lista, Florigio; Costi, Roberta; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |