CORONA, ANGELA
CORONA, ANGELA
DIPARTIMENTO DI SCIENZE DELLA VITA E DELL'AMBIENTE
Dual inhibitors of SARS-CoV-2 Nsp13 helicase functions with broad anti-hCoV activity and combination effects with approved antivirals
2027-01-01 Sanna, Erica; Corona, Angela; Distinto, Simona; Emmolo, Roberta; Maloccu, Stefania; Lupia, Antonio; Onali, Alessia; Fernandes, Carlos; Podda, Enrico; Bavagnoli, Laura; Lodola, Camilla; Crespan, Emmanuele; Schlich, Michele; Meleddu, Rita; Cottiglia, Filippo; Scognamiglio, Sante; Malune, Paolo; Esposito, Francesca; Secci, Daniela; Sequeira, Lisa; Borges, Fernanda; Tramontano, Enzo; Maccioni, Elias
2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition
2026-01-01 Cernicchi, Giada; Nizi, Maria Giulia; Emmolo, Roberta; Persoons, Leentje; Laporte, Manon; Jochmans, Dirk; Romeo, Isabella; Pepe, Giacomo; Milite, Ciro; Campiglia, Pietro; Spezzini, Jacopo; Martelli, Alma; Brogi, Simone; Esposito, Francesca; Felicetti, Tommaso; Massari, Serena; Manfroni, Giuseppe; Sabatini, Stefano; Sbardella, Gianluca; Alcaro, Stefano; Neyts, Johan; Corona, Angela; Tramontano, Enzo; De Jonghe, Steven; Tabarrini, Oriana
A combination of MD-derived pharmacophores and structure-based strategy identifies dual allosteric inhibitors of NS2B-NS3 proteases in Zika and West Nile viruses
2026-01-01 Lupia, Antonio; Nieddu, Salvatore; Demuru, Laura; Sanna, Erica; Onali, Alessia; Emmolo, Roberta; Malune, Paolo; Distinto, Simona; Atzeni, Giulia; Paulis, Annalaura; Meleddu, Rita; Cottiglia, Filippo; Esposito, Francesca; Corona, Angela; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo
Cyclization-Inspired Structural Optimization: Designing Potent Non-nucleoside Reverse Transcriptase Inhibitors with Enhanced Safety and Selectivity
2026-01-01 Zhang, Y. -X.; Pannecouque, C.; Clercq, E. D.; Tramontano, E.; Corona, A.; Dettori, L.; Tran, P. -T.; Li, X. -D.; Su, S.; Wang, S.; Chen, F. -E.
Design and Discovery of Substituted 1,3,4‐Thiadiazole–1,3,5‐Triazine Hybrids as Human Immunodeficiency Virus‐1 Non‐Nucleoside Reverse Transcriptase Inhibitors with Anti‐SARS‐CoV‐2 and Antibacterial Activities
2026-01-01 Singh, Saumya; Srivastava, Kumar Saurabh; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap
Exploring the Pyrimidine Scaffold for the Development of SARSCoV‑2 Mpro Inhibitors
2026-01-01 Nieddu, Salvatore; Ruggieri, G.; De Santis, R.; Malune, Paolo.; Patacchini, E.; Noemi Madia, V.; Saccoliti, F.; Essore, A.; Zarbo, A.; Corona, Angela; Amatore, A.; Grilli, G.; Amoroso, A.; Lista, F.; Tramontano, Enzo; Costi, R.; Di Santo, R.; Esposito, Francesca
Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2
2026-01-01 Maloccu, Stefania; Otsuka, Yuka; Molchan, Elizabeth; Foti, Michelle; Paulis, Annalaura; Vishwakarma, Jyoti; Malune, Paolo; Cottiglia, Filippo; Corona, Angela; Scampavia, Louis; Spicer, Timothy P.; Harris, Reuben S.; Tramontano, Enzo; Fanunza, Elisa
In silico-guided design, synthesis and in vitro evaluation of thiazolo-pyridines targeting SARS-CoV-2 Nsp13
2026-01-01 Bivacqua, Roberta; Emmolo, Roberta; Gualtieri, Gianmarco; Di Martino, Simona; Barreca, Marilia; Spanò, Virginia; Raimondi, Maria Valeria; Corona, Angela; Ortuso, Francesco; Tramontano, Enzo; Romeo, Isabella; Montalbano, Alessandra; Barraja, Paola; Alcaro, Stefano
Infectious Diseases Research in the Global South: Treatments and Treatment Failures
2026-01-01 Wicht, Kathryn; Ganesan, Sandhya; Corona, Angela; Matange, Nishad
Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
2026-01-01 Zhang, Kun; Zhao, Li-Min; Xing, Tianhao; Bu, Yueyue; Wang, Qingyun; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Scaffold hopping yields novel furo[3,2-d]pyrimidine NNRTIs with optimized antiviral potency, enhanced selectivity, and reduced hERG liability
2026-01-01 Zhang, Y. -X.; Pannecouque, C.; De Clercq, E.; Tramontano, E.; Corona, A.; Dettori, L.; Tran, P. -T.; Li, X. -D.; Su, S.; Wang, S.; Chen, F. -E.
Structure-based virtual screening leads to the discovery of a 4,5-dihydropyrazole derivative as the first dual inhibitor of West Nile virus NS3 helicase and protease
2026-01-01 Lupia, Antonio; Emmolo, Roberta; Atzeni, Giulia; Sanna, Erica; Nieddu, Salvatore; Onali, Alessia; Demuru, Laura; Paulis, Annalaura; Distinto, Simona; Corona, Angela; Esposito, Francesca; Meleddu, Rita; Cottiglia, Filippo; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo
Structure–Activity Relationships of Pyrrolyl-Containing Diketo Acid and Non-Diketo Acid Derivatives as Inhibitors of SARS-CoV-2 nsp13-Associated Activities
2026-01-01 Patacchini, E.; Saccoliti, F.; Emmolo, R.; Madia, V. N.; Cara, E.; Albano, A.; Corona, A.; Tramontano, E.; Di Santo, R.; Costi, R.
Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity
2025-01-01 Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap
Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors
2025-01-01 Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er
Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability
2025-01-01 Zhang, K.; Xing, T.; Ding, L.; Pannecouque, C.; De Clercq, E.; Corona, A.; Dettori, L.; Tramontano, E.; Wang, S.; Chen, F. -E.
Dual-Site Inhibition of SARS-CoV2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach
2025-01-01 Malune, Paolo; Iaconis, Daniela; Manelfi, Candida; Giunta, Stefano; Emmolo, Roberta; Lunghini, Filippo; Paulis, Annalaura; Talarico, Carmine; Corona, Angela; Rosario Beccari, Andrea; Tramontano, Enzo; Esposito, Francesca
Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases
2025-01-01 Tu, Nhat Quang; Richetta, Clémence; Putzu, Federica; Delelis, Olivier; Ahmed, Khursheed; Masand, Vijay H.; Schobert, Rainer; Tramontano, Enzo; Corona, Angela; Biersack, Bernhard
Identifying potential allosteric inhibitors of ZIKV NS3pro through a combined computational and biochemical approach
2025-01-01 Demuru, L.; Lupia, A.; Nieddu, S.; Emmolo, R.; Paulis, A.; Esposito, F.; Distinto, S.; Bryant, S. D.; Onali, A.; Sanna, E.; Atzeni, G.; Cottiglia, F.; Grandi, N.; Corona, A.; Tramontano, E.; Maccioni, E.; Meleddu, R.
Meeting report: Seventh summer school on innovative approaches for identification of antiviral agents (IAAASS)
2025-01-01 Corona, Angela; Cagno, Valeria; Grandi, Nicole; Fanunza, Elisa; Esposito, Francesca; Seley-Radtke, Kathie L.; Tramontano, Enzo
| Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
|---|---|---|---|---|
| Dual inhibitors of SARS-CoV-2 Nsp13 helicase functions with broad anti-hCoV activity and combination effects with approved antivirals | 1-gen-2027 | Sanna, Erica; Corona, Angela; Distinto, Simona; Emmolo, Roberta; Maloccu, Stefania; Lupia, Antonio; Onali, Alessia; Fernandes, Carlos; Podda, Enrico; Bavagnoli, Laura; Lodola, Camilla; Crespan, Emmanuele; Schlich, Michele; Meleddu, Rita; Cottiglia, Filippo; Scognamiglio, Sante; Malune, Paolo; Esposito, Francesca; Secci, Daniela; Sequeira, Lisa; Borges, Fernanda; Tramontano, Enzo; Maccioni, Elias | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| 2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition | 1-gen-2026 | Cernicchi, Giada; Nizi, Maria Giulia; Emmolo, Roberta; Persoons, Leentje; Laporte, Manon; Jochmans, Dirk; Romeo, Isabella; Pepe, Giacomo; Milite, Ciro; Campiglia, Pietro; Spezzini, Jacopo; Martelli, Alma; Brogi, Simone; Esposito, Francesca; Felicetti, Tommaso; Massari, Serena; Manfroni, Giuseppe; Sabatini, Stefano; Sbardella, Gianluca; Alcaro, Stefano; Neyts, Johan; Corona, Angela; Tramontano, Enzo; De Jonghe, Steven; Tabarrini, Oriana | CHEMMEDCHEM | - |
| A combination of MD-derived pharmacophores and structure-based strategy identifies dual allosteric inhibitors of NS2B-NS3 proteases in Zika and West Nile viruses | 1-gen-2026 | Lupia, Antonio; Nieddu, Salvatore; Demuru, Laura; Sanna, Erica; Onali, Alessia; Emmolo, Roberta; Malune, Paolo; Distinto, Simona; Atzeni, Giulia; Paulis, Annalaura; Meleddu, Rita; Cottiglia, Filippo; Esposito, Francesca; Corona, Angela; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Cyclization-Inspired Structural Optimization: Designing Potent Non-nucleoside Reverse Transcriptase Inhibitors with Enhanced Safety and Selectivity | 1-gen-2026 | Zhang, Y. -X.; Pannecouque, C.; Clercq, E. D.; Tramontano, E.; Corona, A.; Dettori, L.; Tran, P. -T.; Li, X. -D.; Su, S.; Wang, S.; Chen, F. -E. | JOURNAL OF MEDICINAL CHEMISTRY | - |
| Design and Discovery of Substituted 1,3,4‐Thiadiazole–1,3,5‐Triazine Hybrids as Human Immunodeficiency Virus‐1 Non‐Nucleoside Reverse Transcriptase Inhibitors with Anti‐SARS‐CoV‐2 and Antibacterial Activities | 1-gen-2026 | Singh, Saumya; Srivastava, Kumar Saurabh; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap | CHEMMEDCHEM | - |
| Exploring the Pyrimidine Scaffold for the Development of SARSCoV‑2 Mpro Inhibitors | 1-gen-2026 | Nieddu, Salvatore; Ruggieri, G.; De Santis, R.; Malune, Paolo.; Patacchini, E.; Noemi Madia, V.; Saccoliti, F.; Essore, A.; Zarbo, A.; Corona, Angela; Amatore, A.; Grilli, G.; Amoroso, A.; Lista, F.; Tramontano, Enzo; Costi, R.; Di Santo, R.; Esposito, Francesca | ACS INFECTIOUS DISEASES | - |
| Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2 | 1-gen-2026 | Maloccu, Stefania; Otsuka, Yuka; Molchan, Elizabeth; Foti, Michelle; Paulis, Annalaura; Vishwakarma, Jyoti; Malune, Paolo; Cottiglia, Filippo; Corona, Angela; Scampavia, Louis; Spicer, Timothy P.; Harris, Reuben S.; Tramontano, Enzo; Fanunza, Elisa | ANTIVIRAL RESEARCH | - |
| In silico-guided design, synthesis and in vitro evaluation of thiazolo-pyridines targeting SARS-CoV-2 Nsp13 | 1-gen-2026 | Bivacqua, Roberta; Emmolo, Roberta; Gualtieri, Gianmarco; Di Martino, Simona; Barreca, Marilia; Spanò, Virginia; Raimondi, Maria Valeria; Corona, Angela; Ortuso, Francesco; Tramontano, Enzo; Romeo, Isabella; Montalbano, Alessandra; Barraja, Paola; Alcaro, Stefano | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Infectious Diseases Research in the Global South: Treatments and Treatment Failures | 1-gen-2026 | Wicht, Kathryn; Ganesan, Sandhya; Corona, Angela; Matange, Nishad | ACS INFECTIOUS DISEASES | - |
| Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors | 1-gen-2026 | Zhang, Kun; Zhao, Li-Min; Xing, Tianhao; Bu, Yueyue; Wang, Qingyun; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | CHINESE CHEMICAL LETTERS | - |
| Scaffold hopping yields novel furo[3,2-d]pyrimidine NNRTIs with optimized antiviral potency, enhanced selectivity, and reduced hERG liability | 1-gen-2026 | Zhang, Y. -X.; Pannecouque, C.; De Clercq, E.; Tramontano, E.; Corona, A.; Dettori, L.; Tran, P. -T.; Li, X. -D.; Su, S.; Wang, S.; Chen, F. -E. | ACTA PHARMACEUTICA SINICA B | - |
| Structure-based virtual screening leads to the discovery of a 4,5-dihydropyrazole derivative as the first dual inhibitor of West Nile virus NS3 helicase and protease | 1-gen-2026 | Lupia, Antonio; Emmolo, Roberta; Atzeni, Giulia; Sanna, Erica; Nieddu, Salvatore; Onali, Alessia; Demuru, Laura; Paulis, Annalaura; Distinto, Simona; Corona, Angela; Esposito, Francesca; Meleddu, Rita; Cottiglia, Filippo; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Structure–Activity Relationships of Pyrrolyl-Containing Diketo Acid and Non-Diketo Acid Derivatives as Inhibitors of SARS-CoV-2 nsp13-Associated Activities | 1-gen-2026 | Patacchini, E.; Saccoliti, F.; Emmolo, R.; Madia, V. N.; Cara, E.; Albano, A.; Corona, A.; Tramontano, E.; Di Santo, R.; Costi, R. | MOLECULES | - |
| Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity | 1-gen-2025 | Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap | BIOORGANIC CHEMISTRY | - |
| Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors | 1-gen-2025 | Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er | MOLECULES | - |
| Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability | 1-gen-2025 | Zhang, K.; Xing, T.; Ding, L.; Pannecouque, C.; De Clercq, E.; Corona, A.; Dettori, L.; Tramontano, E.; Wang, S.; Chen, F. -E. | JOURNAL OF MEDICINAL CHEMISTRY | - |
| Dual-Site Inhibition of SARS-CoV2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach | 1-gen-2025 | Malune, Paolo; Iaconis, Daniela; Manelfi, Candida; Giunta, Stefano; Emmolo, Roberta; Lunghini, Filippo; Paulis, Annalaura; Talarico, Carmine; Corona, Angela; Rosario Beccari, Andrea; Tramontano, Enzo; Esposito, Francesca | ACS INFECTIOUS DISEASES | - |
| Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases | 1-gen-2025 | Tu, Nhat Quang; Richetta, Clémence; Putzu, Federica; Delelis, Olivier; Ahmed, Khursheed; Masand, Vijay H.; Schobert, Rainer; Tramontano, Enzo; Corona, Angela; Biersack, Bernhard | MOLECULES | - |
| Identifying potential allosteric inhibitors of ZIKV NS3pro through a combined computational and biochemical approach | 1-gen-2025 | Demuru, L.; Lupia, A.; Nieddu, S.; Emmolo, R.; Paulis, A.; Esposito, F.; Distinto, S.; Bryant, S. D.; Onali, A.; Sanna, E.; Atzeni, G.; Cottiglia, F.; Grandi, N.; Corona, A.; Tramontano, E.; Maccioni, E.; Meleddu, R. | - | - |
| Meeting report: Seventh summer school on innovative approaches for identification of antiviral agents (IAAASS) | 1-gen-2025 | Corona, Angela; Cagno, Valeria; Grandi, Nicole; Fanunza, Elisa; Esposito, Francesca; Seley-Radtke, Kathie L.; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |