Nome |
# |
Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties, file e2f56ed3-d7ec-3eaf-e053-3a05fe0a5d97
|
520
|
Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones, file e2f56ed5-0382-3eaf-e053-3a05fe0a5d97
|
504
|
Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles, file e2f56ed8-91d6-3eaf-e053-3a05fe0a5d97
|
487
|
Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity, file e2f56ed7-e151-3eaf-e053-3a05fe0a5d97
|
461
|
Critical role for prokineticin 2 in CNS autoimmunity, file e2f56ed3-8981-3eaf-e053-3a05fe0a5d97
|
452
|
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors, file e2f56ed8-99b7-3eaf-e053-3a05fe0a5d97
|
217
|
Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy, file e2f56ed7-10b6-3eaf-e053-3a05fe0a5d97
|
211
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Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation, file e2f56ed8-6c8d-3eaf-e053-3a05fe0a5d97
|
210
|
∂-opioid receptor activation protects against Parkinson’s disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy, file e2f56ed9-75c8-3eaf-e053-3a05fe0a5d97
|
210
|
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones, file e2f56ed8-4299-3eaf-e053-3a05fe0a5d97
|
208
|
Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity, file e2f56ed4-6c71-3eaf-e053-3a05fe0a5d97
|
193
|
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context, file e2f56ed3-e642-3eaf-e053-3a05fe0a5d97
|
182
|
In-Vitro Evaluation of Antioxidant, Antiproliferative and Photo-Protective Activities of Benzimidazolehydrazone Derivatives, file e2f56ed8-f11e-3eaf-e053-3a05fe0a5d97
|
140
|
Inhibitory effect of positively charged triazine antagonists of prokinecitin receptors on the transient receptor vanilloid type-1 (TRPV1) channel, file e2f56ed3-dab5-3eaf-e053-3a05fe0a5d97
|
122
|
Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model, file e2f56ed7-9e0f-3eaf-e053-3a05fe0a5d97
|
106
|
Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated, file e2f56ed8-5316-3eaf-e053-3a05fe0a5d97
|
103
|
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore, file e2f56ed8-2f1a-3eaf-e053-3a05fe0a5d97
|
93
|
Delta-opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia, file e2f56ed3-8e0f-3eaf-e053-3a05fe0a5d97
|
82
|
Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors, file e2f56ed9-4a5d-3eaf-e053-3a05fe0a5d97
|
82
|
Opposite Roles of δ- and μ-Opioid Receptors in BACE1 Regulation and Alzheimer’s Injury, file e2f56ed9-474e-3eaf-e053-3a05fe0a5d97
|
75
|
Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy, file e2f56ed8-5ba6-3eaf-e053-3a05fe0a5d97
|
66
|
Halogenated triazinediones behave as antagonists of PKR1: in vitro and in vivo pharmacological characterization, file e2f56ed3-c92c-3eaf-e053-3a05fe0a5d97
|
65
|
Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain, file e2f56ed3-e21f-3eaf-e053-3a05fe0a5d97
|
58
|
Effect of delta-opioid receptor activation on BDNF-TrkB vs. TNF-Alpha in the mouse cortex exposed to prolonged hypoxia, file e2f56ed3-8d1f-3eaf-e053-3a05fe0a5d97
|
57
|
Prokineticins are neuroprotective in models of cerebral ischemia and ischemic tolerance in vitro, file e2f56eda-c5bb-3eaf-e053-3a05fe0a5d97
|
50
|
Synthesis and SIRT1 modulation studies of amides and hydrazides of benzoic acid incorporating a (2-trifluoromethylpyridin-4-yl)amino moiety, file e2f56eda-1085-3eaf-e053-3a05fe0a5d97
|
45
|
DIHYDROQUINAZOLINE BENZYLAMIDES AS ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORS, file e2f56ed9-bfe8-3eaf-e053-3a05fe0a5d97
|
43
|
Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis, file e2f56eda-5844-3eaf-e053-3a05fe0a5d97
|
38
|
Dihydroquinazoline and Triazinedione Derivatives as Prok1 and Prok2 receptor antagonists in HEK-293 transfected cells, file e2f56ed9-e2b4-3eaf-e053-3a05fe0a5d97
|
26
|
Antagonism of EG-VEGF receptors as targeted therapy for choriocarcinoma progression in vitro and in vivo, file e2f56ed6-d800-3eaf-e053-3a05fe0a5d97
|
17
|
Dihydroquinazoline and Triazinedione Derivatives as Prok1 and Prok2 receptor antagonists in HEK-293 transfected cells, file e2f56ed4-41e2-3eaf-e053-3a05fe0a5d97
|
15
|
DIHYDROQUINAZOLINE BENZYLAMIDES AS ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORS, file e2f56ed5-8cec-3eaf-e053-3a05fe0a5d97
|
15
|
Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation, file e2f56eda-b6b4-3eaf-e053-3a05fe0a5d97
|
15
|
Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity, file 68231487-480f-44c1-be80-3b68e7e5d26a
|
14
|
TRPV1 modulators: synthesis and in vitro evaluation of 1-heteroarylpiperidinecarboxamide and piperazinylurea derivatives, file e2f56ed3-f9fa-3eaf-e053-3a05fe0a5d97
|
14
|
null, file e2f56ed8-7b75-3eaf-e053-3a05fe0a5d97
|
14
|
Hair Growth Promotion by δ-Opioid Receptor Activation, file e2f56eda-9540-3eaf-e053-3a05fe0a5d97
|
13
|
Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors, file e2f56eda-1b46-3eaf-e053-3a05fe0a5d97
|
12
|
The antagonism of the prokineticin system counteracts bortezomib induced side effects: Focus on mood alterations, file e2f56eda-6e81-3eaf-e053-3a05fe0a5d97
|
10
|
A Critical Role of δ-Opioid Receptor in Anti-microglial Activation Under Stress, file e2f56eda-d12b-3eaf-e053-3a05fe0a5d97
|
10
|
Investigation on Hydrazonobenzenesulfonamides as Human Carbonic Anhydrase I, II, IX and XII Inhibitors, file 280f0652-38a2-4c34-a7db-94405a57a4f8
|
9
|
Hydrogen Sulfide Increases the Analgesic Effects of µ- and δ-Opioid Receptors during Neuropathic Pain: Pathways Implicated, file a05a2ace-e5c9-4d5a-8df3-923ec6e8ab87
|
9
|
Synthesis and Carbonic Anhydrase Inhibitory Activity
of New 2-Aminochromenone Derivatives, file e2f56ed3-ad3f-3eaf-e053-3a05fe0a5d97
|
9
|
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity, file e2f56ed4-0534-3eaf-e053-3a05fe0a5d97
|
9
|
Evidence-Based View of Safety and Effectiveness of Prokineticin Receptors Antagonists during Pregnancy, file e2f56ed9-ccd4-3eaf-e053-3a05fe0a5d97
|
8
|
Antagonism of EG-VEGF receptors as targeted therapy for choriocarcinoma progression in vitro and in vivo, file e2f56ed6-feeb-3eaf-e053-3a05fe0a5d97
|
7
|
Hydrogen sulfide inhibits inflammatory pain and enhances the analgesic properties of delta opioid receptors, file e2f56eda-8ca4-3eaf-e053-3a05fe0a5d97
|
7
|
Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer, file c33a63e7-f371-46aa-b22f-95a8faf3ae06
|
6
|
Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain, file e2f56ed3-aec4-3eaf-e053-3a05fe0a5d97
|
6
|
Synthesis and SIRT1 modulation studies of amides and hydrazides of benzoic acid incorporating a (2-trifluoromethylpyridin-4-yl)amino moiety, file e2f56ed4-49f8-3eaf-e053-3a05fe0a5d97
|
6
|
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones, file e2f56ed8-57f7-3eaf-e053-3a05fe0a5d97
|
6
|
Prokineticin 1 is a novel factor regulating porcine corpus luteum function, file 16e8e1ec-4305-40bd-8fce-def015b84139
|
5
|
Synthesis and Carbonic Anhydrase Inhibitory Activity
of New 2-Aminochromenone Derivatives, file e2f56ed3-ad3e-3eaf-e053-3a05fe0a5d97
|
5
|
Interaction and reactivity of synthetic aminoisoflavones with metal-free and metalassociated amyloid-beta, file e2f56ed3-fcbe-3eaf-e053-3a05fe0a5d97
|
5
|
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors, file e2f56ed8-d1ff-3eaf-e053-3a05fe0a5d97
|
5
|
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore, file e2f56ed3-bcc2-3eaf-e053-3a05fe0a5d97
|
4
|
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity, file e2f56ed3-e387-3eaf-e053-3a05fe0a5d97
|
4
|
null, file e2f56ed8-c1f5-3eaf-e053-3a05fe0a5d97
|
4
|
Antidepressant-like and anxiolytic-like effects following activation of the mu-delta opioid receptor heteromer in the nucleus accumbens, file e2f56ed3-8caf-3eaf-e053-3a05fe0a5d97
|
3
|
Inhibitory effect of positively charged triazine antagonists of prokinecitin receptors on the transient receptor vanilloid type-1 (TRPV1) channel, file e2f56ed3-e003-3eaf-e053-3a05fe0a5d97
|
3
|
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity, file e2f56ed3-e388-3eaf-e053-3a05fe0a5d97
|
3
|
An important role for prokineticin 2 in autoimmune CNS demyelination, file e2f56ed4-49ca-3eaf-e053-3a05fe0a5d97
|
3
|
Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain, file e2f56ed6-4523-3eaf-e053-3a05fe0a5d97
|
3
|
Genetically Encodable Bacterial Flavin Transferase for Fluorogenic Protein Modification in Mammalian Cells, file e2f56ed6-8645-3eaf-e053-3a05fe0a5d97
|
3
|
Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior, file e2f56ed8-ab88-3eaf-e053-3a05fe0a5d97
|
3
|
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors, file e2f56ed9-2aa2-3eaf-e053-3a05fe0a5d97
|
3
|
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors, file 82615408-bb6e-402c-ac17-7cae78635680
|
2
|
Prokineticin System Is a Pharmacological Target to Counteract Pain and Its Comorbid Mood Alterations in an Osteoarthritis Murine Model, file 8547de6e-ab83-4092-b4cb-ef0ffa256fbf
|
2
|
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors, file c25cfbe5-0c40-404c-8b76-a2c9bf2444ca
|
2
|
PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice, file e2f56ed3-8c21-3eaf-e053-3a05fe0a5d97
|
2
|
A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists, file e2f56ed3-a794-3eaf-e053-3a05fe0a5d97
|
2
|
Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties, file e2f56ed3-bdb7-3eaf-e053-3a05fe0a5d97
|
2
|
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins, file e2f56ed3-e72a-3eaf-e053-3a05fe0a5d97
|
2
|
null, file e2f56ed4-40f8-3eaf-e053-3a05fe0a5d97
|
2
|
null, file e2f56ed4-49f1-3eaf-e053-3a05fe0a5d97
|
2
|
Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives, file e2f56ed4-ee3f-3eaf-e053-3a05fe0a5d97
|
2
|
Prokineticins are neuroprotective in models of cerebral ischemia and ischemic tolerance in vitro, file e2f56ed5-1da2-3eaf-e053-3a05fe0a5d97
|
2
|
Attenuating Ischemic Disruption of K+ Homeostasis in the Cortex of Hypoxic-Ischemic Neonatal Rats: DOR Activation vs. Acupuncture Treatment, file e2f56ed5-db2b-3eaf-e053-3a05fe0a5d97
|
2
|
Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer's disease, file e2f56ed6-79ac-3eaf-e053-3a05fe0a5d97
|
2
|
Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity, file e2f56ed7-b7a1-3eaf-e053-3a05fe0a5d97
|
2
|
Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer's Disease and Type-2 Diabetes, file e2f56ed8-84c9-3eaf-e053-3a05fe0a5d97
|
2
|
The prokineticin receptor antagonist PC1 rescues memory impairment induced by β amyloid administration through the modulation of prokineticin system, file e2f56ed8-b5f6-3eaf-e053-3a05fe0a5d97
|
2
|
Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors, file e2f56ed8-e056-3eaf-e053-3a05fe0a5d97
|
2
|
Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles, file e2f56ed9-3793-3eaf-e053-3a05fe0a5d97
|
2
|
The Impact of UFP-512 in Mice with Osteoarthritis Pain: The Role of Hydrogen Sulfide, file e7f9571b-547c-4695-86a1-cd0a1639cf11
|
2
|
Blocking prokineticin receptors attenuates synovitis and joint destruction in collagen-induced arthritis, file 9c3f5e07-84dd-4bc8-b7fd-4a7fd371100a
|
1
|
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic, file e2f56ed3-7fee-3eaf-e053-3a05fe0a5d97
|
1
|
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging, file e2f56ed3-7ff0-3eaf-e053-3a05fe0a5d97
|
1
|
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore, file e2f56ed3-809f-3eaf-e053-3a05fe0a5d97
|
1
|
Evolution of the bifunctional lead mu agonist / delta antagonist containing the 2',6'-dimethyl-L-tyrosine-1,2,3,4-tetrahydroisoquinoline-3.carboxylic acid (Dmt-Tic) opioid pharmacophore, file e2f56ed3-81e1-3eaf-e053-3a05fe0a5d97
|
1
|
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502), file e2f56ed3-827f-3eaf-e053-3a05fe0a5d97
|
1
|
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold, file e2f56ed3-8385-3eaf-e053-3a05fe0a5d97
|
1
|
null, file e2f56ed3-84f3-3eaf-e053-3a05fe0a5d97
|
1
|
A new opioid designed multiple ligand derived from the mu opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic, file e2f56ed3-863e-3eaf-e053-3a05fe0a5d97
|
1
|
Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic, file e2f56ed3-895b-3eaf-e053-3a05fe0a5d97
|
1
|
Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors, file e2f56ed3-896b-3eaf-e053-3a05fe0a5d97
|
1
|
Ligand- and cell-dependent determinants and cAMP modulation by delta opioid receptor (DOR) agonists, file e2f56ed3-8b97-3eaf-e053-3a05fe0a5d97
|
1
|
δ‐Opioid receptors up‐regulate excitatory amino acid transporters in mouse astrocytes, file e2f56ed3-8c1b-3eaf-e053-3a05fe0a5d97
|
1
|
Structural and biological exploration of Phe3-Phe4-modified endomorphin-2 peptidomimetics, file e2f56ed3-8fdf-3eaf-e053-3a05fe0a5d97
|
1
|
A novel mechanism for cytoprotection against hypoxic injury: delta-opioid receptor-mediated increase in Nrf2 translocation, file e2f56ed3-903c-3eaf-e053-3a05fe0a5d97
|
1
|
Totale |
5.446 |