TRAMONTANO, ENZO
TRAMONTANO, ENZO
DIPARTIMENTO DI SCIENZE DELLA VITA E DELL'AMBIENTE
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase
2015-01-01 Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Francesca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
2020-01-01 Desantis, Jenny; Massari, Serena; Corona, Angela; Astolfi, Andrea; Sabatini, Stefano; Manfroni, Giuseppe; Palazzotti, Deborah; Cecchetti, Violetta; Pannecouque, Christophe; Tramontano, Enzo; Tabarrini, Oriana
2,6-Bis (3,4,5 - trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays
2004-01-01 Costi, R; DI SANTO, R; Artico, M; Massa, S; Ragno, R; Loddo, Roberta; LA COLLA, M; Tramontano, Enzo; LA COLLA, P; Pani, Alessandra
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication
2020-01-01 Corona, Angela; Onnis, Valentina; Del Vecchio, Claudia; Esposito, Francesca; Cheng, Yung-Chi; Tramontano, Enzo
3,4-Dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs): a new class of specific inhibitors of human immunodeficiency virus type 1
1993-01-01 Artico, M; Massa, S; Mai, A; Marongiu, Me; Piras, G; Tramontano, Enzo; LA COLLA, P.
3-[2-(4-aryl-1,3-thiazol-2-yl)hydrazin-1-ylidene]-1H-indol-2-ones as new potential dual inhibitors of polimerase and ribonuclease HIV-1 RT associated function
2011-01-01 Meleddu, Rita; Corona, Angela; Distinto, Simona; Esposito, Francesca; Sanna, M. L.; Cardia, C.; Tramontano, Enzo; Maccioni, Elias
5-alkyl-2-(alkylthio)-6-(2,6-dihalophenyl-methyl)-3,4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives
1999-01-01 Mai, A; Artico, M; Sbardella, G; Massa, S; Novellino, E; Greco, G; Loi, Ag; Tramontano, Enzo; Marongiu, Me; LA COLLA, P.
5-arylaminouracil derivatives as potential dual-action agents
2015-01-01 Matyugina, Es; Novikov, Ms; Babkov, Da; Valuev Elliston, Vt; Vanpouille, C; Zicari, S; Corona, Angela; Tramontano, Enzo; Margolis, Lb; Khandazhinskaya, Al; Kochetkov, Sn
6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach
2013-01-01 Costi, R; Métifiot, M; Esposito, Francesca; Cuzzucoli Crucitti, G; Pescatori, L; Messore, A; Scipione, L; Tortorella, S; Zinzula, Luca; Novellino, E; Pommier, Y; Tramontano, Enzo; Marchand, C; Di Santo, R.
6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-y1)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro
2005-01-01 Tramontano, Enzo; Esposito, Francesca; Badas, R; DI SANTO, R; Costi, R; La, Colla
6-Aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays
2004-01-01 Costi, R; DI SANTO, R; Artico, M; Roux, A; Ragno, R; Massa, S; Tramontano, Enzo; LA COLLA, M; Loddo, Roberta; Marongiu, Me; Pani, Alessandra; LA COLLA, P.
A Homogeneous Time Resolved Fluorescence (HTRF) method for the evaluation of HIV-1 integrase dimerization, enzyme reactions and interaction with LEDGF/p75
2014-01-01 Esposito, Francesca; Tramontano, Enzo
A human MMTV-like betaretrovirus linked to breast cancer has been present in humans at least since the Copper Age
2020-01-01 Lessi, F.; Grandi, N.; Mazzanti, C. M.; Civita, P.; Scatena, C.; Aretini, P.; Bandiera, P.; Fornaciari, A.; Giuffra, V.; Fornaciari, G.; Naccarato, A. G.; Tramontano, E.; Bevilacqua, G.
A Luciferase Reporter Gene Assay to Measure Ebola Virus Viral Protein 35–Associated Inhibition of Double-Stranded RNA–Stimulated, Retinoic Acid–Inducible Gene 1–Mediated Induction of Interferon β
2015-01-01 Cannas, V; Daino, Gl; Corona, Angela; Esposito, Francesca; Tramontano, Enzo
A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity
2016-01-01 Palomba, M.; Rossi, L.; Sancineto, L.; Tramontano, E.; Corona, A.; Bagnoli, L.; Santi, C.; Pannecouque, C.; Tabarrini, O.; Marini, F
A review on the in vitro activity of phosphorothioate oligonucleotides against human immunodeficiency viruses
1993-01-01 De Falco, S; Iacomino, G; Galderisi, U; Cipollaro, M; De Rienzo, A; Galano G., Cascino A; Loi, Ag; Spiga, Mg; Basile, T; Musu, D; DE MONTIS, Antonella; Tramontano, Enzo; Marongiu, Me; La Colla, P.
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus type 1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2butenyl)imidazo[4,5,1,jk][1,4] benzodiazepin-2(1H)-thione (TIBO R82150)
1993-01-01 Mellors, J; Im, Gj; Tramontano, Enzo; Winkler, Sr; Medina, Dj; Dutschman, Ge; Bazmi, Hz; Piras, G; Gonzales, Cj; Cheng, Y. C.
Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase
2013-01-01 Corona, Angela; Masaoka, T; Tocco, Graziella; Tramontano, Enzo; Le Grice, Sfj
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase (RT) -associated DNA polymerase and Ribonuclease H (RNase H) activities effective also on the RNase H activity of non-nucleoside resistant RTs
2010-01-01 Esposito, F.; Kharlamova, T.; Distinto, S.; Zinzula, L.; Cheng, Y-C.; Dutschman, G.; Floris, G.; Markt, P.; Tramontano, E.
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and Ribonuclease H activities effective also on non-nucleoside resistant RTs
2010-01-01 Esposito, F; Kharlamova, T.; Distinto, S.; Zinzula, L.; Floris, G.; Sanna Randaccio, L.; Deutschman, G.; Cheng, Y-C.; Tramontano, E.