TRAMONTANO, ENZO
TRAMONTANO, ENZO
DIPARTIMENTO DI SCIENZE DELLA VITA E DELL'AMBIENTE
2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition
2026-01-01 Cernicchi, Giada; Nizi, Maria Giulia; Emmolo, Roberta; Persoons, Leentje; Laporte, Manon; Jochmans, Dirk; Romeo, Isabella; Pepe, Giacomo; Milite, Ciro; Campiglia, Pietro; Spezzini, Jacopo; Martelli, Alma; Brogi, Simone; Esposito, Francesca; Felicetti, Tommaso; Massari, Serena; Manfroni, Giuseppe; Sabatini, Stefano; Sbardella, Gianluca; Alcaro, Stefano; Neyts, Johan; Corona, Angela; Tramontano, Enzo; De Jonghe, Steven; Tabarrini, Oriana
A combination of MD-derived pharmacophores and structure-based strategy identifies dual allosteric inhibitors of NS2B-NS3 proteases in Zika and West Nile viruses
2026-01-01 Lupia, Antonio; Nieddu, Salvatore; Demuru, Laura; Sanna, Erica; Onali, Alessia; Emmolo, Roberta; Malune, Paolo; Distinto, Simona; Atzeni, Giulia; Paulis, Annalaura; Meleddu, Rita; Cottiglia, Filippo; Esposito, Francesca; Corona, Angela; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo
Cyclization-Inspired Structural Optimization: Designing Potent Non-nucleoside Reverse Transcriptase Inhibitors with Enhanced Safety and Selectivity
2026-01-01 Zhang, Y. -X.; Pannecouque, C.; Clercq, E. D.; Tramontano, E.; Corona, A.; Dettori, L.; Tran, P. -T.; Li, X. -D.; Su, S.; Wang, S.; Chen, F. -E.
Exploring the Pyrimidine Scaffold for the Development of SARSCoV‑2 Mpro Inhibitors
2026-01-01 Nieddu, Salvatore; Ruggieri, G.; De Santis, R.; Malune, Paolo.; Patacchini, E.; Noemi Madia, V.; Saccoliti, F.; Essore, A.; Zarbo, A.; Corona, Angela; Amatore, A.; Grilli, G.; Amoroso, A.; Lista, F.; Tramontano, Enzo; Costi, R.; Di Santo, R.; Esposito, Francesca
Health-Related Quality of Life and Frequency of Depressive Episodes Among Healthcare Professionals in an Outpatient Health Facility in Italy: A Comparison Between 2017 (Pre-COVID) and 2025 (Post-COVID)
2026-01-01 Urban, A.; Atzeni, M.; Cossu, G.; Tusconi, M.; Aviles Gonzales, C. I.; Finco, G.; Madeddu, C.; Atzori, L.; Ferreli, C.; Cotti, E.; Carzedda, M.; Lorrai, S.; Deidda, M. C.; Bertolino, A.; Fragoso Castilla, P. J.; Giraldo Jaramillo, S.; Velluzzi, F.; Montisci, R.; Cantone, E.; Tramontano, E.; Bert, F.; Forte, V.; Nonnis, M.; Carta, M. G.
Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2
2026-01-01 Maloccu, Stefania; Otsuka, Yuka; Molchan, Elizabeth; Foti, Michelle; Paulis, Annalaura; Vishwakarma, Jyoti; Malune, Paolo; Cottiglia, Filippo; Corona, Angela; Scampavia, Louis; Spicer, Timothy P.; Harris, Reuben S.; Tramontano, Enzo; Fanunza, Elisa
Perceptions of care quality and human rights in Italian outpatient facilities during and after the pandemic
2026-01-01 Cantone, Elisa; Kalcev, Goce; Tusconi, Massimo; Perra, Alessandra; Finco, Gabriele; Madeddu, Clelia; Atzori, Laura; Cotti, Elisabetta; Bert, Fabrizio; Preti, Antonio; La Torre, Giuseppe; Carzedda, Mauro; Marra, Orsola; Muscas, Francesco Tomaso; Forte, Viviana; Lorrai, Stefano; La Cascia, Caterina; Dano, Laura Loli; Eskin, Mehmet; Charfi, Fatma; Atzeni, Michela; Tramontano, Enzo; Cossu, Giulia; Carta, Mauro Giovanni
Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
2026-01-01 Zhang, Kun; Zhao, Li-Min; Xing, Tianhao; Bu, Yueyue; Wang, Qingyun; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Report from the 9th Italian Society for Virology (SIV-ISV) 2025 Annual Meeting
2026-01-01 De Filippis, Anna; Donalisio, Manuela; Luganini, Anna; Caccuri, Francesca; Esposito, Francesca; Grandi, Nicole; Zannella, Carla; Rubino, Luisa; Tramontano, Enzo; Vaccari, Gabriele; Galdiero And Arnaldo Caruso, Massimiliano
Structure-based virtual screening leads to the discovery of a 4,5-dihydropyrazole derivative as the first dual inhibitor of West Nile virus NS3 helicase and protease
2026-01-01 Lupia, Antonio; Emmolo, Roberta; Atzeni, Giulia; Sanna, Erica; Nieddu, Salvatore; Onali, Alessia; Demuru, Laura; Paulis, Annalaura; Distinto, Simona; Corona, Angela; Esposito, Francesca; Meleddu, Rita; Cottiglia, Filippo; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo
The role of hypothyroidism in the resilience against depressive episodes during covid pandemic in a cohort of old adults
2026-01-01 Perra, Alessandra; Tusconi, Massimo; Cantone, Elisa; Atzeni, Michela; Tramontano, Enzo; Lorrai, Stefano; Bert, Fabrizio; Nardi, Antonio E.; Carta, Mauro Giovanni; Cossu, Giulia
γ-Monoalkyl triphosphate analogues of acyclic nucleoside phosphonates inhibit SARS-CoV-2 replication in vitro by inducing dissociation of the minimal replication-transcription complex
2026-01-01 Malune, Paolo; Kullik, G.; Jia, X.; Bandowski, G.; Esposito, Francesca; Lupia, A.; Distinto, S.; Accioni, E.; Meier, C.; Tramontano, Enzo.
2-(Trihydroxyphenyl)thienopyrimidinones as Key Scaffolds for Targeting a Novel Allosteric Site of HIV-1 Integrase
2025-01-01 Tocco, Graziella; Laus, Antonio; Casula, Mattia; Caboni, Pierluigi; Beutler, John A.; Tramontano, Enzo; Esposito, Francesca
Characterization of SARS-CoV-2 nucleocapsid protein oligomers
2025-01-01 Farci, Domenica; Graça, André T; Hall, Michael; Haniewicz, Patrycja; Kereïche, Sami; Faull, Peter; Kirkpatrick, Joanna; Tramontano, Enzo; Schröder, Wolfgang P; Piano, Dario
Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity
2025-01-01 Iacobucci, I.; Cipollone, I.; Cozzolino, F.; Iaconis, D.; Talarico, C.; Coppola, G.; Morasso, S.; Costanzi, E.; Malune, Paolo; Storici, P.; Tramontano, E.; Esposito, Francesca; Monti, M.
Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity
2025-01-01 Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap
Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors
2025-01-01 Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er
Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability
2025-01-01 Zhang, K.; Xing, T.; Ding, L.; Pannecouque, C.; De Clercq, E.; Corona, A.; Dettori, L.; Tramontano, E.; Wang, S.; Chen, F. -E.
Dual-Site Inhibition of SARS-CoV2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach
2025-01-01 Malune, Paolo; Iaconis, Daniela; Manelfi, Candida; Giunta, Stefano; Emmolo, Roberta; Lunghini, Filippo; Paulis, Annalaura; Talarico, Carmine; Corona, Angela; Rosario Beccari, Andrea; Tramontano, Enzo; Esposito, Francesca
HERV Modulation in Colorectal Carcinoma Patients: A Snapshot of Endogenous Retroviral Transcriptome
2025-01-01 Grandi, Nicole; Liu, Ching‐hsuan; Chabukswar, Saili; Carta, Daniele; Yen, Yun; Lin, Liang‐tzung; Tramontano, Enzo
| Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
|---|---|---|---|---|
| 2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition | 1-gen-2026 | Cernicchi, Giada; Nizi, Maria Giulia; Emmolo, Roberta; Persoons, Leentje; Laporte, Manon; Jochmans, Dirk; Romeo, Isabella; Pepe, Giacomo; Milite, Ciro; Campiglia, Pietro; Spezzini, Jacopo; Martelli, Alma; Brogi, Simone; Esposito, Francesca; Felicetti, Tommaso; Massari, Serena; Manfroni, Giuseppe; Sabatini, Stefano; Sbardella, Gianluca; Alcaro, Stefano; Neyts, Johan; Corona, Angela; Tramontano, Enzo; De Jonghe, Steven; Tabarrini, Oriana | CHEMMEDCHEM | - |
| A combination of MD-derived pharmacophores and structure-based strategy identifies dual allosteric inhibitors of NS2B-NS3 proteases in Zika and West Nile viruses | 1-gen-2026 | Lupia, Antonio; Nieddu, Salvatore; Demuru, Laura; Sanna, Erica; Onali, Alessia; Emmolo, Roberta; Malune, Paolo; Distinto, Simona; Atzeni, Giulia; Paulis, Annalaura; Meleddu, Rita; Cottiglia, Filippo; Esposito, Francesca; Corona, Angela; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Cyclization-Inspired Structural Optimization: Designing Potent Non-nucleoside Reverse Transcriptase Inhibitors with Enhanced Safety and Selectivity | 1-gen-2026 | Zhang, Y. -X.; Pannecouque, C.; Clercq, E. D.; Tramontano, E.; Corona, A.; Dettori, L.; Tran, P. -T.; Li, X. -D.; Su, S.; Wang, S.; Chen, F. -E. | JOURNAL OF MEDICINAL CHEMISTRY | - |
| Exploring the Pyrimidine Scaffold for the Development of SARSCoV‑2 Mpro Inhibitors | 1-gen-2026 | Nieddu, Salvatore; Ruggieri, G.; De Santis, R.; Malune, Paolo.; Patacchini, E.; Noemi Madia, V.; Saccoliti, F.; Essore, A.; Zarbo, A.; Corona, Angela; Amatore, A.; Grilli, G.; Amoroso, A.; Lista, F.; Tramontano, Enzo; Costi, R.; Di Santo, R.; Esposito, Francesca | ACS INFECTIOUS DISEASES | - |
| Health-Related Quality of Life and Frequency of Depressive Episodes Among Healthcare Professionals in an Outpatient Health Facility in Italy: A Comparison Between 2017 (Pre-COVID) and 2025 (Post-COVID) | 1-gen-2026 | Urban, A.; Atzeni, M.; Cossu, G.; Tusconi, M.; Aviles Gonzales, C. I.; Finco, G.; Madeddu, C.; Atzori, L.; Ferreli, C.; Cotti, E.; Carzedda, M.; Lorrai, S.; Deidda, M. C.; Bertolino, A.; Fragoso Castilla, P. J.; Giraldo Jaramillo, S.; Velluzzi, F.; Montisci, R.; Cantone, E.; Tramontano, E.; Bert, F.; Forte, V.; Nonnis, M.; Carta, M. G. | JOURNAL OF CLINICAL MEDICINE | - |
| Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2 | 1-gen-2026 | Maloccu, Stefania; Otsuka, Yuka; Molchan, Elizabeth; Foti, Michelle; Paulis, Annalaura; Vishwakarma, Jyoti; Malune, Paolo; Cottiglia, Filippo; Corona, Angela; Scampavia, Louis; Spicer, Timothy P.; Harris, Reuben S.; Tramontano, Enzo; Fanunza, Elisa | ANTIVIRAL RESEARCH | - |
| Perceptions of care quality and human rights in Italian outpatient facilities during and after the pandemic | 1-gen-2026 | Cantone, Elisa; Kalcev, Goce; Tusconi, Massimo; Perra, Alessandra; Finco, Gabriele; Madeddu, Clelia; Atzori, Laura; Cotti, Elisabetta; Bert, Fabrizio; Preti, Antonio; La Torre, Giuseppe; Carzedda, Mauro; Marra, Orsola; Muscas, Francesco Tomaso; Forte, Viviana; Lorrai, Stefano; La Cascia, Caterina; Dano, Laura Loli; Eskin, Mehmet; Charfi, Fatma; Atzeni, Michela; Tramontano, Enzo; Cossu, Giulia; Carta, Mauro Giovanni | FRONTIERS IN PUBLIC HEALTH | - |
| Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors | 1-gen-2026 | Zhang, Kun; Zhao, Li-Min; Xing, Tianhao; Bu, Yueyue; Wang, Qingyun; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | CHINESE CHEMICAL LETTERS | - |
| Report from the 9th Italian Society for Virology (SIV-ISV) 2025 Annual Meeting | 1-gen-2026 | De Filippis, Anna; Donalisio, Manuela; Luganini, Anna; Caccuri, Francesca; Esposito, Francesca; Grandi, Nicole; Zannella, Carla; Rubino, Luisa; Tramontano, Enzo; Vaccari, Gabriele; Galdiero And Arnaldo Caruso, Massimiliano | VIRUSES | - |
| Structure-based virtual screening leads to the discovery of a 4,5-dihydropyrazole derivative as the first dual inhibitor of West Nile virus NS3 helicase and protease | 1-gen-2026 | Lupia, Antonio; Emmolo, Roberta; Atzeni, Giulia; Sanna, Erica; Nieddu, Salvatore; Onali, Alessia; Demuru, Laura; Paulis, Annalaura; Distinto, Simona; Corona, Angela; Esposito, Francesca; Meleddu, Rita; Cottiglia, Filippo; Bryant, Sharon D.; Maccioni, Elias; Tramontano, Enzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| The role of hypothyroidism in the resilience against depressive episodes during covid pandemic in a cohort of old adults | 1-gen-2026 | Perra, Alessandra; Tusconi, Massimo; Cantone, Elisa; Atzeni, Michela; Tramontano, Enzo; Lorrai, Stefano; Bert, Fabrizio; Nardi, Antonio E.; Carta, Mauro Giovanni; Cossu, Giulia | FRONTIERS IN PSYCHIATRY | - |
| γ-Monoalkyl triphosphate analogues of acyclic nucleoside phosphonates inhibit SARS-CoV-2 replication in vitro by inducing dissociation of the minimal replication-transcription complex | 1-gen-2026 | Malune, Paolo; Kullik, G.; Jia, X.; Bandowski, G.; Esposito, Francesca; Lupia, A.; Distinto, S.; Accioni, E.; Meier, C.; Tramontano, Enzo. | ANTIVIRAL RESEARCH | - |
| 2-(Trihydroxyphenyl)thienopyrimidinones as Key Scaffolds for Targeting a Novel Allosteric Site of HIV-1 Integrase | 1-gen-2025 | Tocco, Graziella; Laus, Antonio; Casula, Mattia; Caboni, Pierluigi; Beutler, John A.; Tramontano, Enzo; Esposito, Francesca | MOLECULES | - |
| Characterization of SARS-CoV-2 nucleocapsid protein oligomers | 1-gen-2025 | Farci, Domenica; Graça, André T; Hall, Michael; Haniewicz, Patrycja; Kereïche, Sami; Faull, Peter; Kirkpatrick, Joanna; Tramontano, Enzo; Schröder, Wolfgang P; Piano, Dario | JOURNAL OF STRUCTURAL BIOLOGY | - |
| Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity | 1-gen-2025 | Iacobucci, I.; Cipollone, I.; Cozzolino, F.; Iaconis, D.; Talarico, C.; Coppola, G.; Morasso, S.; Costanzi, E.; Malune, Paolo; Storici, P.; Tramontano, E.; Esposito, Francesca; Monti, M. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
| Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity | 1-gen-2025 | Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap | BIOORGANIC CHEMISTRY | - |
| Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors | 1-gen-2025 | Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er | MOLECULES | - |
| Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability | 1-gen-2025 | Zhang, K.; Xing, T.; Ding, L.; Pannecouque, C.; De Clercq, E.; Corona, A.; Dettori, L.; Tramontano, E.; Wang, S.; Chen, F. -E. | JOURNAL OF MEDICINAL CHEMISTRY | - |
| Dual-Site Inhibition of SARS-CoV2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach | 1-gen-2025 | Malune, Paolo; Iaconis, Daniela; Manelfi, Candida; Giunta, Stefano; Emmolo, Roberta; Lunghini, Filippo; Paulis, Annalaura; Talarico, Carmine; Corona, Angela; Rosario Beccari, Andrea; Tramontano, Enzo; Esposito, Francesca | ACS INFECTIOUS DISEASES | - |
| HERV Modulation in Colorectal Carcinoma Patients: A Snapshot of Endogenous Retroviral Transcriptome | 1-gen-2025 | Grandi, Nicole; Liu, Ching‐hsuan; Chabukswar, Saili; Carta, Daniele; Yen, Yun; Lin, Liang‐tzung; Tramontano, Enzo | JOURNAL OF MEDICAL VIROLOGY | - |