Based on several findings suggesting that the adenosinergic system is one of the most interesting in the field of neuroprotection in Parkinson’s disease, this chapter describes the functions of the purine adenosine and its A2A receptors in the central nervous system, with emphasis on their role in neuroprotection. The neuromodulatory role of A2A receptors and the preclinical and epidemiological studies on the mechanisms of the neuroprotective role of caffeine and urate, the final product of purine catabolism, are extensively discussed in the light of their potential modifying effects on Parkinson’s disease.

Protective Agents in Parkinson’s Disease: Caffeine and Adenosine A2A Receptor Antagonists

Simola, Nicola
Primo
Writing – Review & Editing
;
Pinna, Annalisa
Writing – Original Draft Preparation
;
Frau, Lucia
Writing – Original Draft Preparation
;
Costa, Giulia
Writing – Original Draft Preparation
;
Marongiu, Jacopo
Writing – Original Draft Preparation
;
Parekh, Pathik
Writing – Original Draft Preparation
;
Serra, Marcello
Writing – Original Draft Preparation
;
Morelli, Micaela
Ultimo
Writing – Review & Editing
2021-01-01

Abstract

Based on several findings suggesting that the adenosinergic system is one of the most interesting in the field of neuroprotection in Parkinson’s disease, this chapter describes the functions of the purine adenosine and its A2A receptors in the central nervous system, with emphasis on their role in neuroprotection. The neuromodulatory role of A2A receptors and the preclinical and epidemiological studies on the mechanisms of the neuroprotective role of caffeine and urate, the final product of purine catabolism, are extensively discussed in the light of their potential modifying effects on Parkinson’s disease.
2021
978-3-030-71519-9
Animal models; 6-OHDA; Basal ganglia; Epidemiological studies; Glia; MPTP; Neurodegeneration; Neuroinflammation; Purines; Urate
File in questo prodotto:
File Dimensione Formato  
Simola et al 2021_HB of Neurotoxicity.pdf

Solo gestori archivio

Tipologia: versione editoriale
Dimensione 424.51 kB
Formato Adobe PDF
424.51 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/326161
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact