UNICA IRIS Institutional Research Information System

2-(Trihydroxyphenyl)thienopyrimidinones as Key Scaffolds for Targeting a Novel Allosteric Site of HIV-1 Integrase

A promising novel class of 2-(trihydroxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-ones as HIV-1 integrase (IN) allosteric inhibitors is reported. All compounds were considerably more effective than the control compound LEDGIN-6, showing an inhibitory activity in the low micromolar range in both the HIV-1 integrase LEDGF/p75-dependent and independent activity assays. Selected compounds 6, 9, 10, and 12 were also able to affect the exchange of the HIV-1 IN-IN subunit and the interaction between IN an...

Enriched Płonka sums

Płonka sums are a powerful technique for the representation of algebras in regular varieties. However, certain representations of algebras in irregular varieties—like Polin’s variety or the variety of pseudocomplemented semilattices—bear striking similarities to Płonka sums, although they differ from them in some important respects. We aim at finding a convenient umbrella under which these constructions, as well as other ones of a similar kind, can be subsumed. Inspired by Grätzer and Sichler...

Technical-economic evaluation for maximizing the self-consumption contribution in an energy community: The case study of Pattada in Sardinia

Ministerial Decree 414/2023 implements Legislative Decree 199 which defines the conditions and methods under which producers, consumers, and prosumers have the right to organize themselves into Renewable Energy Communities (REC), promoting the production and sharing of electricity from renewable sources. The economic feasibility of an energy community is largely influenced by its investment options: public capital only, third-party co-financing, or direct investment by interested households. ...

Paesaggi per l’apprendimento. Alimentare processi di conoscenza nei territori a bassa densità