UNICA IRIS Institutional Research Information System

Toward a Unified Definition of Progression Independent of Relapse Activity in Multiple Sclerosis

OBJECTIVES: Progression independent of relapse activity (PIRA) is the main driver of disability accumulation in relapsing multiple sclerosis (MS). We tested various PIRA definitions against the risk of long-term disability. METHODS: Patients with relapsing MS, first visit ≥January 1, 2000, ≥3 visits with Expanded Disability Status Scale (EDSS), and ≥5-year follow-up were extracted from the Italian MS and Related Disorders Register on September 29, 2023. Eighteen PIRA definitions were obtained...

Minimizing LCOA in green ammonia production: optimization of components size and scheduling under varying curtailment scenarios

Large-scale online assessment uncovers a distinct Multiple Sclerosis subtype with selective cognitive impairment

Cognitive impairments in Multiple Sclerosis (MS) are prevalent and disabling yet often unaddressed. Here, we optimised automated online assessment technology for people with MS and used it to characterise their cognitive deficits in greater detail and at a larger population scale than previously possible. The study involved 4526 UK MS Register members over three stages. Stage 1 evaluated 22 online cognitive tasks and established their feasibility. Based on MS discriminability a 12-task batter...

Challenging confidence: how essentialist, microaggressive, and medicalizing attitudes shape italian psychologists’ work with trans* individuals

Introduction Trans* individuals continue to face profound health inequities compared to cisgender populations, including barriers to appropriate and affirming mental health care. Research highlights gaps in individualized services, insufficient training, and persistent microaggressions and heterocisnormative attitudes among healthcare professionals. These barriers are shaped not only by deficits in knowledge but also by deeper normative and epistemological frameworks. This study addresses an...