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Images always on the edge. A conversation

Una conversazione tra Ana Petrović, artista, e Luca Vargiu, studioso di estetica, su alcune opere dell’artista che affrontano il problema della relazione tra l’immagine e i suoi bordi o margini secondo molteplici prospettive.

The Antidepressant Amitriptyline Upregulates ERK1/2 Signaling and Inhibits Rho-Mediated Responses Induced by Lysophosphatidic Acid in Astroglial Cells

(1) Different classes of antidepressant drugs have been shown to activate lysophosphatidic acid (LPA) receptors, but their effects on the receptor signaling stimulated by LPA have not been fully investigated. In the present study, we examined the effect of the tricyclic antidepressant amitriptyline on the LPA-induced activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and Rho signaling in C6 glioma cells and cultured rat astrocytes. (2) LPA receptor signaling was investigate...

Epigenetic Regulation of Trk Receptors and Neurotrophic Signalling in Neuroblastoma: Mechanisms, Plasticity, and Therapeutic Opportunities

Neuroblastoma (NB) represents a paradigmatic developmental malignancy in which lineage specification, oncogenic signalling, and epigenetic regulation converge to define tumour behaviour. Among the molecular axes shaping NB heterogeneity, neurotrophin receptors of the tropomyosin receptor kinase (Trk) family (TrkA, TrkB, and TrkC) and the p75NTR occupy a central position at the intersection between neuronal differentiation programs and malignant plasticity. While high TrkA and TrkC expression ...

A comparison of Wolff’s and Kant’s receptions of Emanuel Swedenborg

Kant’s Dreams of a Spirit-Seer (1766) did not provide the sole perspective through which Emanuel Swedenborg’s work was known in Germany in the eighteenth century. Before Kant, another German philosopher was interested in Swedenborg from a completely different perspective: Christian Wolff. On the one hand, this paper analyzes the meaning of Wolff’s anonymous reviews of Swedenborg’s early writings published in Acta Eruditorum, the authorship of which was only recently discovered, in order t...

Age and gender effects on molecular responses in chronic myeloid leukemia patients by first-line treatment: an Italian CML network cohort study

Among prognostic factors influencing the achievement of molecular responses in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs), age has been suggested with contrasting results, while the role of gender is still uncertain. A large cohort of 1,394 newly diagnosed CML patients was analyzed by data collected in the Italian CML Network, evaluating the effect of age and gender on the probability of deep molecular responses (DMR). With a median follow-up of 5 y...

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