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Liver Innervation in Health and Disease: Neuroimmune–Neurovascular Interface and Future Therapeutic Implications

The liver is intricately innervated by sympathetic, parasympathetic, and sensory fibres, forming a dynamic neurovascular and neuroimmune network that regulates hepatic function and contributes to disease pathogenesis. While traditionally underexplored, hepatic innervation is now recognised as a key modulator of metabolic homeostasis, immune surveillance, and vascular tone. Historically, the liver was not considered a major target of neural regulation, but recent advances in neurology and imag...

Understanding Commitment to Change in Family and Non-Family Business: The Role of Psychological Ownership and Open and Transparent Communication

Organizational change is essential for business adaptability, yet its success depends on employees’ commitment to change. This study explores the role of psychological ownership and open and transparent communication in shaping commitment to change within family and non-family firms. Using moderated mediation modelling on data from 501 employees across 14 Italian firms, findings reveal that psychological ownership fully mediates the relationship between open and transparent communicati...

Beta-Blockers and Long-Term Mortality in Takotsubo Syndrome: Results of the Multicenter GEIST Registry

BACKGROUND Beta-blockers are considered a reasonable therapy for patients with Takotsubo syndrome (TTS), commonly used despite the absence of consistent evidence about its prognosis impact. OBJECTIVES This study aimed to assess the impact of beta-blocker therapy on long-term mortality and TTS recurrence. METHODS The authors analyzed 2,853 patients discharged with a confirmed TTS diagnosis, enrolled in the international multicenter GEIST (The GErman Italian Spanish Takotsubo Registry). They pe...