Sulfonamides are an important class of compounds with a broad array of biological and pharmacological activities . Drugs containing a sulfonamide moiety have wide-ranging applications in many areas of clinical medicine, as they act as effective antibacterials, diuretics, anticonvulsants, hypoglycemics and HIV protease inhibitors . Recently, sulfonamides have been shown to be potent carbonic anhydrase , matrix metalloproteinase  and 11β-hydroxysteroid dehydrogenase type 1 inhibitors .The preparation of sulfonamides is normally achieved by reacting an amine with a substituted sulfonyl chloride or anhydride where a buffering base in an aprotic solvent is present .
|Titolo:||Microwave-assisted synthesis of sulfonamides|
|Data di pubblicazione:||2014|
|Tipologia:||2.1 Contributo in volume (Capitolo o Saggio)|