LEDDA, GIOVANNA MARIA
LEDDA, GIOVANNA MARIA
DIPARTIMENTO DI SCIENZE BIOMEDICHE
Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming
2020-01-01 Kowalik, M. A.; Puliga, E.; Cabras, L.; Sulas, P.; Petrelli, A.; Perra, A.; Ledda-Columbano, G. M.; Morandi, A.; Merlin, S.; Orru, C.; Sanchez-Martin, C.; Fornari, F.; Gramantieri, L.; Parri, M.; Rasola, A.; Bellomo, S. E.; Sebastian, C.; Follenzi, A.; Giordano, S.; Columbano, A.
The thyromimetic KB2115 (Eprotirome) induces rat hepatocyte proliferation
2017-01-01 Szydlowska, Marta; Pibiri, Monica; Perra, Andrea; Puliga, Elisabetta; Mattu, Sandra; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Leoni, VERA PIERA
Induction of autophagy promotes the growth of early preneoplastic rat liver nodules
2016-01-01 Kowalik, MARTA ANNA; Perra, Andrea; Ledda, GIOVANNA MARIA; Ippolito, G; Piacentini, M; Columbano, Amedeo; Falasca, L.
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis
2016-01-01 Kowalik, MARTA ANNA; Guzzo, Giulia; Morandi, Andrea; Perra, Andrea; Menegon, Silvia; Masgras, Ionica; Trevisan, Elena; Angioni, MARIA MADDALENA; Fornari, Francesca; Quagliata, Luca; Ledda, GIOVANNA MARIA; Gramantieri, Laura; Terracciano, Luigi; Giordano, Silvia; Chiarugi, Paola; Rasola, Andrea; Columbano, Amedeo
The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival
2016-01-01 Mattu, S; Fornari, F; Quagliata, L; Perra, Andrea; Angioni, MARIA MADDALENA; Petrelli, A; Menegon, S; Morandi, A; Chiarugi, P; Ledda, GIOVANNA MARIA; Gramantieri, L; Terracciano, L; Giordano, S; Columbano, Amedeo
Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis
2015-01-01 Kowalik, MARTA ANNA; Sulas, Pia; Ledda, GIOVANNA MARIA; Giordano, S; Columbano, Amedeo; Perra, Andrea
Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats
2015-01-01 Frau, C; Loi, Roberto; Petrelli, A; Perra, Andrea; Menegon, S; Kowalik, MARTA ANNA; Pinna, S; Leoni, VERA PIERA; Fornari, F; Gramantieri, L; Ledda, GIOVANNA MARIA; Giordano, S; Columbano, Amedeo
Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis
2015-01-01 Zavattari, Patrizia; Perra, Andrea; Menegon, S; Kowalik, MARTA ANNA; Petrelli, A; Angioni, MARIA MADDALENA; Follenzi, A; Quagliata, L; Ledda, GIOVANNA MARIA; Terracciano, L; Giordano, S; Columbano, Amedeo
MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).
2014-01-01 Petrelli, A; Perra, Andrea; Cora, D; Sulas, P; Menegon, S; Manca, C; Migliore, C; Kowalik M., A; Ledda, GIOVANNA MARIA; Giordano, S; Columbano, Amedeo
Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration
2014-01-01 Rizzo, F; Hashim, A; Marchese, G; Ravo, M; Tarallo, R; Nassa, G; Giurato, G; Rinaldi, A; Cordella, A; Persico, M; Sulas, P; Perra, Andrea; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Weisz, A.
Triiodothyronine induces hepatocyte proliferation by protein kinase A-dependent-b-catenin activation in rodents.
2014-01-01 Fanti, M; Singh, S; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Monga, S. P.
YAP activation is an early event and a potential therapeutic target in liver cancer development
2014-01-01 Perra, Andrea; Kowalik, Ma; Ghiso, E; Ledda, GIOVANNA MARIA; Di Tommaso, L; Angioni, MARIA MADDALENA; Raschioni, C; Testore, E; Roncalli, M; Giordano, S; Columbano, Amedeo
Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression
2012-01-01 Petrelli, A; Perra, Andrea; Schernhuber, K; Cargnelutti, M; Salvi, A; Migliore, C; Ghiso, E; Benetti, A; Barlati, S; Ledda, GIOVANNA MARIA; Portolani, N; De Petro, G; Columbano, Amedeo; Giordano, S.
Transcription profiling by array of mouse liver from TCPOBOP treated wild type and c-jun conditional knockout animals.
2012-01-01 Leoni, Vp; Ledda, GIOVANNA MARIA; Pibiri, Monica; Saliba, C; Perra, Andrea; Kowalik, Ma; Grober Oli, Mv; Ravo, M; Weisz, A; Ghiso, E; Giordano, S; Columbano, A.
Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3
2011-01-01 Leoni, VERA PIERA; Ledda, GIOVANNA MARIA; Pibiri, Monica; Saliba, C; Perra, Andrea; Kowalik, MARTA ANNA; Grober, Om; Ravo, M; Weisz, A; Locker, J; Ghiso, E; Giordano, S; Columbano, Amedeo
Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice
2011-01-01 Tian, J; Huang, H; Hoffman, B; Liebermann D., A; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Locker, J.
Proteomic characterization of early changes induced by triiodothyronine in rat liver
2011-01-01 Severino, V; Locker, J; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Parente, A; Chambery, A.
Reply to: Clinical correlation of miR-375 and alpha-fetoprotein in hepatocellular carcinoma: comparison in mice and humans
2011-01-01 Kowalik, MARTA ANNA; Ledda, GIOVANNA MARIA; Giordano, S; Columbano, Amedeo
Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice
2011-01-01 Kowalik, MARTA ANNA; Saliba, C; Pibiri, Monica; Perra, Andrea; Ledda, GIOVANNA MARIA; Sarotto, I; Ghiso, E; Giordano, S; Columbano, Amedeo
Progenitor-derived hepatocellular carcinoma model in the rat
2010-01-01 Andersen, Jb; Loi, Roberto; Perra, Andrea; Factor, Vm; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Thorgeirsson, S. S.
| Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
|---|---|---|---|---|
| Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming | 1-gen-2020 | Kowalik, M. A.; Puliga, E.; Cabras, L.; Sulas, P.; Petrelli, A.; Perra, A.; Ledda-Columbano, G. M.; Morandi, A.; Merlin, S.; Orru, C.; Sanchez-Martin, C.; Fornari, F.; Gramantieri, L.; Parri, M.; Rasola, A.; Bellomo, S. E.; Sebastian, C.; Follenzi, A.; Giordano, S.; Columbano, A. | JOURNAL OF HEPATOLOGY | - |
| The thyromimetic KB2115 (Eprotirome) induces rat hepatocyte proliferation | 1-gen-2017 | Szydlowska, Marta; Pibiri, Monica; Perra, Andrea; Puliga, Elisabetta; Mattu, Sandra; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Leoni, VERA PIERA | GENE EXPRESSION | - |
| Induction of autophagy promotes the growth of early preneoplastic rat liver nodules | 1-gen-2016 | Kowalik, MARTA ANNA; Perra, Andrea; Ledda, GIOVANNA MARIA; Ippolito, G; Piacentini, M; Columbano, Amedeo; Falasca, L. | ONCOTARGET | - |
| Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis | 1-gen-2016 | Kowalik, MARTA ANNA; Guzzo, Giulia; Morandi, Andrea; Perra, Andrea; Menegon, Silvia; Masgras, Ionica; Trevisan, Elena; Angioni, MARIA MADDALENA; Fornari, Francesca; Quagliata, Luca; Ledda, GIOVANNA MARIA; Gramantieri, Laura; Terracciano, Luigi; Giordano, Silvia; Chiarugi, Paola; Rasola, Andrea; Columbano, Amedeo | ONCOTARGET | - |
| The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival | 1-gen-2016 | Mattu, S; Fornari, F; Quagliata, L; Perra, Andrea; Angioni, MARIA MADDALENA; Petrelli, A; Menegon, S; Morandi, A; Chiarugi, P; Ledda, GIOVANNA MARIA; Gramantieri, L; Terracciano, L; Giordano, S; Columbano, Amedeo | JOURNAL OF HEPATOLOGY | - |
| Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis | 1-gen-2015 | Kowalik, MARTA ANNA; Sulas, Pia; Ledda, GIOVANNA MARIA; Giordano, S; Columbano, Amedeo; Perra, Andrea | ONCOTARGET | - |
| Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats | 1-gen-2015 | Frau, C; Loi, Roberto; Petrelli, A; Perra, Andrea; Menegon, S; Kowalik, MARTA ANNA; Pinna, S; Leoni, VERA PIERA; Fornari, F; Gramantieri, L; Ledda, GIOVANNA MARIA; Giordano, S; Columbano, Amedeo | HEPATOLOGY | - |
| Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis | 1-gen-2015 | Zavattari, Patrizia; Perra, Andrea; Menegon, S; Kowalik, MARTA ANNA; Petrelli, A; Angioni, MARIA MADDALENA; Follenzi, A; Quagliata, L; Ledda, GIOVANNA MARIA; Terracciano, L; Giordano, S; Columbano, Amedeo | HEPATOLOGY | - |
| MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC). | 1-gen-2014 | Petrelli, A; Perra, Andrea; Cora, D; Sulas, P; Menegon, S; Manca, C; Migliore, C; Kowalik M., A; Ledda, GIOVANNA MARIA; Giordano, S; Columbano, Amedeo | HEPATOLOGY | - |
| Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration | 1-gen-2014 | Rizzo, F; Hashim, A; Marchese, G; Ravo, M; Tarallo, R; Nassa, G; Giurato, G; Rinaldi, A; Cordella, A; Persico, M; Sulas, P; Perra, Andrea; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Weisz, A. | HEPATOLOGY | - |
| Triiodothyronine induces hepatocyte proliferation by protein kinase A-dependent-b-catenin activation in rodents. | 1-gen-2014 | Fanti, M; Singh, S; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Monga, S. P. | HEPATOLOGY | - |
| YAP activation is an early event and a potential therapeutic target in liver cancer development | 1-gen-2014 | Perra, Andrea; Kowalik, Ma; Ghiso, E; Ledda, GIOVANNA MARIA; Di Tommaso, L; Angioni, MARIA MADDALENA; Raschioni, C; Testore, E; Roncalli, M; Giordano, S; Columbano, Amedeo | JOURNAL OF HEPATOLOGY | - |
| Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression | 1-gen-2012 | Petrelli, A; Perra, Andrea; Schernhuber, K; Cargnelutti, M; Salvi, A; Migliore, C; Ghiso, E; Benetti, A; Barlati, S; Ledda, GIOVANNA MARIA; Portolani, N; De Petro, G; Columbano, Amedeo; Giordano, S. | ONCOGENE | - |
| Transcription profiling by array of mouse liver from TCPOBOP treated wild type and c-jun conditional knockout animals. | 1-gen-2012 | Leoni, Vp; Ledda, GIOVANNA MARIA; Pibiri, Monica; Saliba, C; Perra, Andrea; Kowalik, Ma; Grober Oli, Mv; Ravo, M; Weisz, A; Ghiso, E; Giordano, S; Columbano, A. | - | - |
| Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3 | 1-gen-2011 | Leoni, VERA PIERA; Ledda, GIOVANNA MARIA; Pibiri, Monica; Saliba, C; Perra, Andrea; Kowalik, MARTA ANNA; Grober, Om; Ravo, M; Weisz, A; Locker, J; Ghiso, E; Giordano, S; Columbano, Amedeo | JOURNAL OF HEPATOLOGY | - |
| Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice | 1-gen-2011 | Tian, J; Huang, H; Hoffman, B; Liebermann D., A; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Locker, J. | THE JOURNAL OF CLINICAL INVESTIGATION | - |
| Proteomic characterization of early changes induced by triiodothyronine in rat liver | 1-gen-2011 | Severino, V; Locker, J; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Parente, A; Chambery, A. | JOURNAL OF PROTEOME RESEARCH | - |
| Reply to: Clinical correlation of miR-375 and alpha-fetoprotein in hepatocellular carcinoma: comparison in mice and humans | 1-gen-2011 | Kowalik, MARTA ANNA; Ledda, GIOVANNA MARIA; Giordano, S; Columbano, Amedeo | HEPATOLOGY | - |
| Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice | 1-gen-2011 | Kowalik, MARTA ANNA; Saliba, C; Pibiri, Monica; Perra, Andrea; Ledda, GIOVANNA MARIA; Sarotto, I; Ghiso, E; Giordano, S; Columbano, Amedeo | HEPATOLOGY | - |
| Progenitor-derived hepatocellular carcinoma model in the rat | 1-gen-2010 | Andersen, Jb; Loi, Roberto; Perra, Andrea; Factor, Vm; Ledda, GIOVANNA MARIA; Columbano, Amedeo; Thorgeirsson, S. S. | HEPATOLOGY | - |