| Nome |
# |
|
Identification of Myricetin as Ebolavirus VP35-dsRNA interaction inhibitor through a novel fluorescence-based assay, file e2f56ed8-3c40-3eaf-e053-3a05fe0a5d97
|
858
|
|
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions, file e2f56ed7-ec87-3eaf-e053-3a05fe0a5d97
|
603
|
|
Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops, file e2f56ed7-ade3-3eaf-e053-3a05fe0a5d97
|
458
|
|
RhVI1 is a membrane-anchored vacuolar invertase highly expressed in Rosa hybrida L. petals, file e2f56ed5-a3c9-3eaf-e053-3a05fe0a5d97
|
294
|
|
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives, file e2f56ed4-ea17-3eaf-e053-3a05fe0a5d97
|
201
|
|
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives, file e2f56ed4-eab0-3eaf-e053-3a05fe0a5d97
|
183
|
|
Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans, file e2f56ed4-760f-3eaf-e053-3a05fe0a5d97
|
179
|
|
Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6, file e2f56ed5-3c4f-3eaf-e053-3a05fe0a5d97
|
139
|
|
Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication, file e2f56ed7-819e-3eaf-e053-3a05fe0a5d97
|
134
|
|
Development and identification of a novel anti-HIV-1 peptide derived by modification of the N-terminal domain of HIV-1 integrase, file e2f56ed5-3595-3eaf-e053-3a05fe0a5d97
|
132
|
|
From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors, file e2f56eda-c47e-3eaf-e053-3a05fe0a5d97
|
127
|
|
Chelation motifs affecting metal-dependent viral enzymes: N′-acylhydrazone ligands as dual target inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H domain, file e2f56ed6-5d51-3eaf-e053-3a05fe0a5d97
|
121
|
|
Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion, file e2f56ed7-0941-3eaf-e053-3a05fe0a5d97
|
120
|
|
Inhibitory effect of 2,3,5,6-tetrafluoro-4-[4-(Aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide derivatives on HIV reverse transcriptase associated rnase H activities, file e2f56ed5-4495-3eaf-e053-3a05fe0a5d97
|
115
|
|
Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H, file e2f56ed9-70ec-3eaf-e053-3a05fe0a5d97
|
103
|
|
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase, file e2f56ed9-b9fe-3eaf-e053-3a05fe0a5d97
|
103
|
|
Biological activities of aerial parts extracts of Euphorbia characias, file e2f56ed5-7e31-3eaf-e053-3a05fe0a5d97
|
98
|
|
Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication, file e2f56eda-a012-3eaf-e053-3a05fe0a5d97
|
85
|
|
Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture, file e2f56ed9-9ba0-3eaf-e053-3a05fe0a5d97
|
82
|
|
Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata, file e2f56eda-2734-3eaf-e053-3a05fe0a5d97
|
80
|
|
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication, file e2f56ed8-ef23-3eaf-e053-3a05fe0a5d97
|
79
|
|
Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants, file e2f56ed9-05dc-3eaf-e053-3a05fe0a5d97
|
62
|
|
Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities, file e2f56eda-4279-3eaf-e053-3a05fe0a5d97
|
60
|
|
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity, file 365c76e3-371b-4c83-bad3-3733586012f5
|
57
|
|
Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions, file e2f56eda-222c-3eaf-e053-3a05fe0a5d97
|
55
|
|
S-layer proteins as a source of carotenoids: Isolation of the carotenoid cofactor deinoxanthin from its S-layer protein DR_2577, file 2f209d12-3a01-4d46-ae46-d5a358542955
|
52
|
|
HIV-1 Reverse Transcriptase still remains a new drug target: Structure, Function, Classical inhibitors and new inhibitors with innovative mechanism of action, file e2f56ed3-9855-3eaf-e053-3a05fe0a5d97
|
48
|
|
Probing the importance of the g-quadruplex grooves for the activity of the anti-hiv-integrase aptamer t30923, file e2f56ed9-74e6-3eaf-e053-3a05fe0a5d97
|
39
|
|
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase, file e04e01a7-d295-4712-b05a-1faf6cc4ad84
|
38
|
|
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route, file def774fa-3ac8-40e7-abdc-0714228d24cb
|
36
|
|
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity, file e2f56eda-d9b8-3eaf-e053-3a05fe0a5d97
|
36
|
|
Structure-Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain, file e2f56eda-ac16-3eaf-e053-3a05fe0a5d97
|
24
|
|
Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses, file 6b855124-992c-4c43-8ef2-855a76f51167
|
18
|
|
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions, file e2f56ed6-c3c4-3eaf-e053-3a05fe0a5d97
|
18
|
|
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination, file 0effbeee-38bd-4178-bd9e-0014730ca7c7
|
17
|
|
Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase, file e2f56ed3-8eb6-3eaf-e053-3a05fe0a5d97
|
12
|
|
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action, file 8362faad-16eb-4d5f-8845-2fa29ef1697b
|
11
|
|
Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H, file e2f56eda-681a-3eaf-e053-3a05fe0a5d97
|
11
|
|
Euphorbia characias latex: Micromorphology of rubber particles and rubber transferase activity, file e2f56ed5-7a24-3eaf-e053-3a05fe0a5d97
|
10
|
|
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity, file e2f56ed8-bbb0-3eaf-e053-3a05fe0a5d97
|
9
|
|
HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France), file acd42975-a84f-43d0-a7d6-2b0d54b2b3a4
|
7
|
|
From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors, file e2f56ed3-bba7-3eaf-e053-3a05fe0a5d97
|
7
|
|
Design and synthesis of new isatin derivatives as HIV-1 reverse transcriptase associated ribonuclease H inhibitors, file e2f56ed3-dcd9-3eaf-e053-3a05fe0a5d97
|
7
|
|
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions, file e2f56ed6-be95-3eaf-e053-3a05fe0a5d97
|
7
|
|
On the S-layer of Thermus thermophilus and the assembling of its main protein SIpA, file e2f56ed7-ea9e-3eaf-e053-3a05fe0a5d97
|
7
|
|
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen, file e2f56ed9-edd0-3eaf-e053-3a05fe0a5d97
|
7
|
|
Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication, file e2f56ed5-2f58-3eaf-e053-3a05fe0a5d97
|
6
|
|
Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors, file e2f56ed5-352a-3eaf-e053-3a05fe0a5d97
|
6
|
|
DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action, file 25d17fb2-9959-4c53-b5aa-50635e005829
|
5
|
|
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases, file e2f56ed4-7606-3eaf-e053-3a05fe0a5d97
|
5
|
|
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H, file e2f56ed5-a01e-3eaf-e053-3a05fe0a5d97
|
5
|
|
In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds, file e2f56eda-7f6d-3eaf-e053-3a05fe0a5d97
|
5
|
|
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort, file 5fb86745-212e-4b85-8e18-8bdb83f4b848
|
4
|
|
Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor, file 80744b2f-2ffb-4412-a9d7-ba6ea0064377
|
4
|
|
Design and synthesis of new isatin derivatives as HIV-1 reverse transcriptase associated ribonuclease H inhibitors, file e2f56ed3-dcda-3eaf-e053-3a05fe0a5d97
|
4
|
|
Inhibition of HIV-1 reverse transcriptase dimerization by small molecules, file e2f56ed4-f873-3eaf-e053-3a05fe0a5d97
|
4
|
|
Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments, file e2f56ed5-2f82-3eaf-e053-3a05fe0a5d97
|
4
|
|
Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding, file e2f56ed6-3558-3eaf-e053-3a05fe0a5d97
|
4
|
|
New insights into the operative network of FaEO, an enone oxidoreductase from Fragaria x ananassa Duch, file e2f56ed6-fc9b-3eaf-e053-3a05fe0a5d97
|
4
|
|
Structure-guided approach identifies a novel class of HIV-1 Ribonuclease H inhibitors: Binding mode insights through magnesium complexation and site-directed mutagenesis studies, file e2f56ed7-43e3-3eaf-e053-3a05fe0a5d97
|
4
|
|
S-layer proteins as a source of carotenoids: Isolation of the carotenoid cofactor deinoxanthin from its S-layer protein DR_2577, file 17ecaa3b-76e0-4db2-ad08-107bbae99362
|
3
|
|
Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach, file aeba8af2-0f72-445e-9b31-6b55bae30301
|
3
|
|
Structure-Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain, file e2f56ed3-9cfd-3eaf-e053-3a05fe0a5d97
|
3
|
|
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach, file e2f56ed4-75d9-3eaf-e053-3a05fe0a5d97
|
3
|
|
Kuwanon-L as a new allosteric HIV-1 integrase inhibitor: molecular modeling and biological evaluation, file e2f56ed4-f875-3eaf-e053-3a05fe0a5d97
|
3
|
|
New anthraquinone derivatives as inhibitors of the HIV-1 reverse transcriptase-associated ribonuclease H function, file e2f56ed5-310f-3eaf-e053-3a05fe0a5d97
|
3
|
|
Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action, file e2f56ed6-d1cc-3eaf-e053-3a05fe0a5d97
|
3
|
|
Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy), file e2f56ed8-8e4b-3eaf-e053-3a05fe0a5d97
|
3
|
|
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors, file e2f56ed8-e3dc-3eaf-e053-3a05fe0a5d97
|
3
|
|
ANTIBACTERIAL COATING, file e2f56eda-7ed9-3eaf-e053-3a05fe0a5d97
|
3
|
|
Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity, file 70f7802d-bc83-4212-bdf2-76166a328d4b
|
2
|
|
Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting the main protease Mpro, file 8c03c212-ba5f-43e4-b973-8cb3dc900aae
|
2
|
|
An efficient route to novel uracil-based drug-like molecules, file e2f56ed3-8afd-3eaf-e053-3a05fe0a5d97
|
2
|
|
Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development?, file e2f56ed3-9ade-3eaf-e053-3a05fe0a5d97
|
2
|
|
dsRNA binding characterization of full length recombinant wild type and mutants Zaire ebolavirus VP35, file e2f56ed3-a64b-3eaf-e053-3a05fe0a5d97
|
2
|
|
Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities, file e2f56ed3-b2fd-3eaf-e053-3a05fe0a5d97
|
2
|
|
Past and future. Current drugs targeting HIV-1 integrase and reverse transcriptase-associated ribonuclease H activity: single and dual active site inhibitors, file e2f56ed3-b4af-3eaf-e053-3a05fe0a5d97
|
2
|
|
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach, file e2f56ed3-b97f-3eaf-e053-3a05fe0a5d97
|
2
|
|
Inhibition of HIV-1 reverse transcriptase associated activities by the hydroalcoholic extract of Casimiroa edulis seeds, file e2f56ed3-c9ba-3eaf-e053-3a05fe0a5d97
|
2
|
|
6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach, file e2f56ed4-f311-3eaf-e053-3a05fe0a5d97
|
2
|
|
Validation of a computed radiography device to monitor the HIV-1 RNase H activity, file e2f56ed3-8b3b-3eaf-e053-3a05fe0a5d97
|
1
|
|
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and Ribonuclease H activities effective also on non-nucleoside resistant RTs, file e2f56ed3-9acc-3eaf-e053-3a05fe0a5d97
|
1
|
|
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase (RT) -associated DNA polymerase and Ribonuclease H (RNase H) activities effective also on the RNase H activity of non-nucleoside resistant RTs, file e2f56ed3-9b48-3eaf-e053-3a05fe0a5d97
|
1
|
|
Inhibition of HIV-1 Ribonuclease H activity by novel frangula-emodine derivatives, file e2f56ed3-9bed-3eaf-e053-3a05fe0a5d97
|
1
|
|
A Luciferase Reporter Gene Assay to Measure Ebola Virus Viral Protein 35–Associated Inhibition of Double-Stranded RNA–Stimulated, Retinoic Acid–Inducible Gene 1–Mediated Induction of Interferon β, file e2f56ed3-9f02-3eaf-e053-3a05fe0a5d97
|
1
|
|
null, file e2f56ed3-aee2-3eaf-e053-3a05fe0a5d97
|
1
|
|
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity, file e2f56ed3-b0cd-3eaf-e053-3a05fe0a5d97
|
1
|
|
Shape based computer aided similarity screening: a valid tool in the discovery of new scaffolds for the inhibition of HIV-1 reverse transcriptase associated ribonuclease H function, file e2f56ed3-bc59-3eaf-e053-3a05fe0a5d97
|
1
|
|
Effects of new quinizarin derivatives on both HCV NS5B RNA polymerase and HIV-1 reverse transcriptase associated ribonuclease H activities, file e2f56ed3-bda4-3eaf-e053-3a05fe0a5d97
|
1
|
|
Mutagenic study on HIV-1 reverse transcriptase to explore the mechanism of action of HIV-1 reverse transcriptase dual inhibitors, file e2f56ed3-be80-3eaf-e053-3a05fe0a5d97
|
1
|
|
null, file e2f56ed4-e6be-3eaf-e053-3a05fe0a5d97
|
1
|
|
Onopordum illyricum L., a Mediterranean plant, as a source of anti HIV-1 compounds, file e2f56ed8-029f-3eaf-e053-3a05fe0a5d97
|
1
|
|
null, file e2f56ed8-a31a-3eaf-e053-3a05fe0a5d97
|
1
|
| Totale |
5.076 |