In this paper, a novel approach for DNA hybridization detection by means of organic field-effect transistors-based biosensors (bioFETs) is proposed. The reported device, namely Organic Charge-Modulated FET (OCMFET), is conceived for overcoming the main limitations of bioFETs, related to design, materials and measurement conditions. In particular, record performances in terms of sensitivity and selectivity will be reported. Moreover, as innovative features among bioFETs, the detection ability of the OCMFET at relatively high ionic strengths will be carefully discussed, unravelling the interactions between the bioreceptors characteristics at the nano-scale and the device polarization.

Organic FET-based DNA hybridization sensor with sub-picomolar sensitivity

LAI, STEFANO;BARBARO, MASSIMO;BONFIGLIO, ANNALISA
2015

Abstract

In this paper, a novel approach for DNA hybridization detection by means of organic field-effect transistors-based biosensors (bioFETs) is proposed. The reported device, namely Organic Charge-Modulated FET (OCMFET), is conceived for overcoming the main limitations of bioFETs, related to design, materials and measurement conditions. In particular, record performances in terms of sensitivity and selectivity will be reported. Moreover, as innovative features among bioFETs, the detection ability of the OCMFET at relatively high ionic strengths will be carefully discussed, unravelling the interactions between the bioreceptors characteristics at the nano-scale and the device polarization.
9781424492718
1707; Signal Processing; Biomedical Engineering; Health Informatics
File in questo prodotto:
File Dimensione Formato  
2015-EMBS.pdf

Solo gestori archivio

Tipologia: versione editoriale
Dimensione 861.42 kB
Formato Adobe PDF
861.42 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11584/169083
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact