In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4'-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for further design and synthetize new non-purinergic derivatives as potential compounds involved in the inflammatory suppression, specially related to the gout.
Titolo: | Interest of 3-arylcoumarins as xanthine oxidase inhibitors |
Autori: | |
Data di pubblicazione: | 2015 |
Handle: | http://hdl.handle.net/11584/183260 |
Tipologia: | 4.1 Contributo in Atti di convegno |
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