Study of a series of 8-substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE inhibitors

Matos, Maria João; Borges, Fernanda; Santana, Lourdes; Uriarte, Eugenio; Medda, Rosaria; Murgia, Adriana; Di Petrillo, Amalia; Era, Benedetta; Fais, Antonella; Pintus, Francesca

doi:10.3390/ecmc-1-A027

In the current work we studied the interest of a series of 8-substitued 7-hydroxy-4-methylcoumarins as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. For the best compounds of the series, the IC50 value was determined. This work was based on previous results and is a preliminary screening for further design and synthesis of new derivatives as potential compounds that can modulate enzymatic systems involved in the neurodegenerative diseases.

Trovami (UniCASearch)

Titolo:	Study of a series of 8-substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE inhibitors
Autori:	Matos, Maria João Borges, Fernanda Santana, Lourdes Uriarte, Eugenio MEDDA, ROSARIA Murgia, Adriana DI PETRILLO, AMALIA ERA, BENEDETTA FAIS, ANTONELLA PINTUS, FRANCESCA mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Handle:	http://hdl.handle.net/11584/183262
Tipologia:	4.1 Contributo in Atti di convegno

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http://hdl.handle.net/11584/183262

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