In the current work we studied the interest of a series of 8-substitued 7-hydroxy-4-methylcoumarins as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. For the best compounds of the series, the IC50 value was determined. This work was based on previous results and is a preliminary screening for further design and synthesis of new derivatives as potential compounds that can modulate enzymatic systems involved in the neurodegenerative diseases.
Titolo: | Study of a series of 8-substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE inhibitors |
Autori: | |
Data di pubblicazione: | 2015 |
Handle: | http://hdl.handle.net/11584/183262 |
Tipologia: | 4.1 Contributo in Atti di convegno |
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