The muscle metaboreflex activation has been shown essential to reach normal hemodynamic response during exercise. It has been demonstrated in numerous studies that patients with multiple sclerosis (MS) have impaired autonomic functions and cardiovascular regulation during exercise. However, to the best of our knowledge, no previous research to date has studied the metaboreflex in MS patients. The purpose of this study was to investigate the hemodynamic response to metaboreflex activation in patients with MS (n= 43) compared to an age-matched, control group (CTL, n= 21). Cardiovascular response during the metaboreflex activation was evaluated using the post-exercise muscle ischemia (PEMI) method and during a control exercise recovery (CER) test. The difference in hemodynamic parameters between the PEMI and the CER test was calculated and this procedure allowed for the assessment of the metaboreflex response. Hemodynamics was estimated by impedance cardiography. The MS group showed a normal mean blood pressure (MBP) response as compared to the CTL group (+6.5±6.9 vs. +8±6.8 mmHg respectively), but this response was achieved with an increase in systemic vascular resistance (SVR), that was higher in the MS with respect to the CTL group (+137.6±300.5 vs. -14.3±240 dyne·s-1·cm-5 respectively). This was the main consequence of the MS group’s incapacity to raise the stroke volume (-0.65±10.6 vs. +6.2±12.8 ml respectively). It was concluded that MS patients have an impaired capacity to increase stroke volume (SV) in response to metaboreflex activation, even if they could sustain the MBP response by vasoconstriction. This was probably a consequence of their chronic physical de-conditioning.

La risposta cardiocircolatoria all’attivazione dei metaboriflessi muscolari nella sclerosi multipla

LOI, ANDREA
2016-03-18

Abstract

The muscle metaboreflex activation has been shown essential to reach normal hemodynamic response during exercise. It has been demonstrated in numerous studies that patients with multiple sclerosis (MS) have impaired autonomic functions and cardiovascular regulation during exercise. However, to the best of our knowledge, no previous research to date has studied the metaboreflex in MS patients. The purpose of this study was to investigate the hemodynamic response to metaboreflex activation in patients with MS (n= 43) compared to an age-matched, control group (CTL, n= 21). Cardiovascular response during the metaboreflex activation was evaluated using the post-exercise muscle ischemia (PEMI) method and during a control exercise recovery (CER) test. The difference in hemodynamic parameters between the PEMI and the CER test was calculated and this procedure allowed for the assessment of the metaboreflex response. Hemodynamics was estimated by impedance cardiography. The MS group showed a normal mean blood pressure (MBP) response as compared to the CTL group (+6.5±6.9 vs. +8±6.8 mmHg respectively), but this response was achieved with an increase in systemic vascular resistance (SVR), that was higher in the MS with respect to the CTL group (+137.6±300.5 vs. -14.3±240 dyne·s-1·cm-5 respectively). This was the main consequence of the MS group’s incapacity to raise the stroke volume (-0.65±10.6 vs. +6.2±12.8 ml respectively). It was concluded that MS patients have an impaired capacity to increase stroke volume (SV) in response to metaboreflex activation, even if they could sustain the MBP response by vasoconstriction. This was probably a consequence of their chronic physical de-conditioning.
18-mar-2016
aggiustamenti cardiovascolari
autonomic system
cardiovascular regulation
esercizio fisico
exercise
gittata sistolica
resistenze vascolari sistemiche
sistema nervoso autonomo
stroke volume
systemic vascular resistance
File in questo prodotto:
File Dimensione Formato  
PhD_Thesis_LoiA.pdf

accesso aperto

Tipologia: Tesi di dottorato
Dimensione 1.14 MB
Formato Adobe PDF
1.14 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/266653
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact