Cerebral white matter status and resting state functional MRI.

White Matter (WM) is a pivotal component of the Central Nervous System (CNS), and its main role is the transmission of the neural impulses within the CNS and between CNS and Peripheral Nervous System (PNS). It is note from literature that changes in the WM affects the function of the CNS with effects on the higher neurological function, included cognition. Further, it has been theorized in the last decades that ageing-associated decline in higher neurological functions, in particular in the neurocognitive sphere, could be at least partly explained by the “disconnection” of the cortical areas of the brain due to the WM degeneration. Although standard “in-vivo” imaging biomarkers of WM integrity have not been validated yet for clinical purposes, several researches have demonstrated the correlation between different potential imaging biomarkers and WM integrity. The aim of the PhD project is to explore and better understanding the effects of WM status on the brain structure, networking and cognition. In particular, we designed three distinct explorative and cross-sectional studies; more specifically, we analyzed the effects of two Magnetic Resonance Imaging (MRI) markers of WM degeneration (the global Fractional Anisotropy (gFA) and the white matter hyperintensities burden (WMHb), respectively) on the brain activity measured with the Resting-State Functional Magnetic Resonance Imaging (rs-fMRI) technique. The project was conducted by analyzing a human population of healthy subjects extracted from the public available dataset “Leipzig Study for Mind-Body-Emotion Interactions” (LEMON). The results of these studies have been published during the PhD course on three distinct international scientific papers.