Neuro-electronic devices and nanotools to interact with neuronal networks

Neuro-electronic interfaces play a fundamental role for studying brain functions and cellular mechanisms of information processing both in vitro and in vivo. Here we present a new concept in which electronic devices are integrated with models of neuronal networks of human origin together with nanotools to characterize the (patho)physiology of such in vitro complex systems. Large-scale CMOS micro-transducer arrays, coupled to 2D and 3D networks are presented together with new techniques for non-invasively modulate the cell activity. Specifically, piezo-electric nano particles and gold nano rods are used to excite-inhibit the neural activity that is recorded by the micro-transducer arrays. Concept, technology, and preliminary results are presented toward the implementation of a bio-hybrid brain-on-a-chip.