Assessment of QT variability in Parkinson's disease and REM sleep behaviour disorder during REM phase

QT interval variability (QTV) is a marker of ventricular repolarization variability, frequently associated with sympathetic outflow and cardiovascular risk. This study explores QTV in drug-naϊve ten Parkison's disease (PD), ten PD with Rapid Eye Movement (REM) Sleep Behavior Disorder (PD-RBD) subjects, and ten control (CG) participants. Five minutes of ECG data from polysomnographic recordings during REM sleep were used for analysis. To assess QTV, both time domain and frequency domain indexes were calculated. The results indicated higher QTV in PD groups compared to both CG and RBDpd, suggesting significant cardiac autonomic dysregulation in PD patients.