USE - The peptide of SEQ ID NO: 3 is useful for treating and/or preventing HIV infection, and/or eradication of HIV virus from viral reservoirs in individuals suffering from HIV and/or in therapy for AIDS (claimed). The peptide of SEQ ID NO: 3 has antifungal activity. The antifungal activity of the peptide of SEQ ID NO: 3 (100 mu g/ml) was tested against Cryptococcus neoformans 6995. The result showed that the peptide exhibited an EC50 value of 1.764x 10-5 moles/l. ADVANTAGE - The peptide of SEQ ID NO: 3 is non-toxic and exhibits improved stability. DETAILED DESCRIPTION - Peptide of SEQ ID NO: 3 (comprising a fully defined 15 amino acids sequence given in the specification) is new. INDEPENDENT CLAIMS are included for: (1) a nucleotide sequence coding for the peptide of SEQ ID NO: 3; (2) a composition comprising the peptide of SEQ ID NO: 3 as active principle and a carrier; and (3) a kit for concomitant or sequential administration, comprising one or more aliquots of the antiviral peptide of SEQ ID NO: 3 as active principle in a carrier and one or more aliquots of one or more of a active principles comprising peptide of SEQ ID NO: 2 (comprising a fully defined 28 amino acids sequence given in the specification), peptide of SEQ ID NO: 1 (comprising a fully defined 20 amino acids sequence given in the specification), nucleoside inhibitors, non-nucleoside inhibitors, reverse transcriptase inhibitors, integrase inhibitors, viral protease inhibitors, antimycotics, antibacterials, and virus-host cell fusion process inhibitors.
New peptide, useful for treating and/or preventing HIV infection, and/or eradication of HIV virus from viral reservoirs in individuals suffering from HIV and/or in therapy for AIDS and has antifungal activity
MESSANA, IRENE;CABRAS, TIZIANA;
2011-01-01
Abstract
USE - The peptide of SEQ ID NO: 3 is useful for treating and/or preventing HIV infection, and/or eradication of HIV virus from viral reservoirs in individuals suffering from HIV and/or in therapy for AIDS (claimed). The peptide of SEQ ID NO: 3 has antifungal activity. The antifungal activity of the peptide of SEQ ID NO: 3 (100 mu g/ml) was tested against Cryptococcus neoformans 6995. The result showed that the peptide exhibited an EC50 value of 1.764x 10-5 moles/l. ADVANTAGE - The peptide of SEQ ID NO: 3 is non-toxic and exhibits improved stability. DETAILED DESCRIPTION - Peptide of SEQ ID NO: 3 (comprising a fully defined 15 amino acids sequence given in the specification) is new. INDEPENDENT CLAIMS are included for: (1) a nucleotide sequence coding for the peptide of SEQ ID NO: 3; (2) a composition comprising the peptide of SEQ ID NO: 3 as active principle and a carrier; and (3) a kit for concomitant or sequential administration, comprising one or more aliquots of the antiviral peptide of SEQ ID NO: 3 as active principle in a carrier and one or more aliquots of one or more of a active principles comprising peptide of SEQ ID NO: 2 (comprising a fully defined 28 amino acids sequence given in the specification), peptide of SEQ ID NO: 1 (comprising a fully defined 20 amino acids sequence given in the specification), nucleoside inhibitors, non-nucleoside inhibitors, reverse transcriptase inhibitors, integrase inhibitors, viral protease inhibitors, antimycotics, antibacterials, and virus-host cell fusion process inhibitors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.