NOVELTY - A peptide having specific amino acid sequence with antiviral and antimycotic activity, is new. USE - In a medical treatment; in the treatment or prevention of HIV infection; and for eradication of HIV virus from viral reservoirs in individuals suffering from HIV or in therapy for AIDS (claimed). ADVANTAGE - The peptide exhibits antiviral and antimycotic activity; exhibits very low cytotoxicity, and very high stability; exhibits good antimycotic activity, tested in particular on fungi particularly aggressive and commonly active in immunocompromized patients such as patient suffering from AIDS; and exhibits exceptional set of features which make them suitable for medical use in the therapy against HIV infection. DETAILED DESCRIPTION - A peptide having amino acid sequence containing 20 amino acids (SEQ ID NO: 1), as given in the specification with antiviral and antimycotic activity, is new. INDEPENDENT CLAIMS are included for the following: (1) new nucleotide sequence coding for the peptide of (SEQ ID NO: 1); (2) a pharmaceutical composition comprising an antiviral peptide of (SEQ ID NO: 1) as active principle and carrier; and (3) a pharmaceutical kit for concomitant or sequential administration comprising at least one aliquot of the antiviral peptide of (SEQ ID NO: 1) as active principle in a carrier and at least one aliquot of at least one of the active principles selected from: peptide having amino acid sequence containing 28 amino acids (SEQ ID NO: 2), 15 amino acids (SEQ ID NO: 3), as given in the specification, nucleoside inhibitors; non-nucleoside inhibitors; reverse transcriptase inhibitors; integrase inhibitors; viral protease inhibitors; antimycotics; antibacterials; and virus-host cell fusion process inhibitors.
New peptide having specific amino acid sequence with antiviral and antimycotic activity, useful in the treatment or prevention of HIV infection, and for eradication of HIV virus from viral reservoirs in individuals suffering from HIV
MESSANA, IRENE;CABRAS, TIZIANA;
2011-01-01
Abstract
NOVELTY - A peptide having specific amino acid sequence with antiviral and antimycotic activity, is new. USE - In a medical treatment; in the treatment or prevention of HIV infection; and for eradication of HIV virus from viral reservoirs in individuals suffering from HIV or in therapy for AIDS (claimed). ADVANTAGE - The peptide exhibits antiviral and antimycotic activity; exhibits very low cytotoxicity, and very high stability; exhibits good antimycotic activity, tested in particular on fungi particularly aggressive and commonly active in immunocompromized patients such as patient suffering from AIDS; and exhibits exceptional set of features which make them suitable for medical use in the therapy against HIV infection. DETAILED DESCRIPTION - A peptide having amino acid sequence containing 20 amino acids (SEQ ID NO: 1), as given in the specification with antiviral and antimycotic activity, is new. INDEPENDENT CLAIMS are included for the following: (1) new nucleotide sequence coding for the peptide of (SEQ ID NO: 1); (2) a pharmaceutical composition comprising an antiviral peptide of (SEQ ID NO: 1) as active principle and carrier; and (3) a pharmaceutical kit for concomitant or sequential administration comprising at least one aliquot of the antiviral peptide of (SEQ ID NO: 1) as active principle in a carrier and at least one aliquot of at least one of the active principles selected from: peptide having amino acid sequence containing 28 amino acids (SEQ ID NO: 2), 15 amino acids (SEQ ID NO: 3), as given in the specification, nucleoside inhibitors; non-nucleoside inhibitors; reverse transcriptase inhibitors; integrase inhibitors; viral protease inhibitors; antimycotics; antibacterials; and virus-host cell fusion process inhibitors.
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