This invention relates to new 1H-Pyrrol-1-yl and 1H-Indol-1-yl Aryl Sulphones of Formula (I) that may by useful in the medical therapy of retrovirus infections and in particular of HIV-1 infections. The compounds reported herein may be used alone or in combination with other antiretroviral compounds, preferably chosen among reverse transcriptase inhibitors such as, for example, nucleoside analogues, wherein: R<1> = NO2, NH2, halogen, NHCH2Z(Z = H, alkyl, aryl, heteroaryl), NHCOW (W = H, alkyl, aryl, heteroaryl); R<2> = H, halogen; R<3> = R<4> = H, NO2, NH2, CH3, halogen; R<5> = H, (2)-COX, (3)-COX, (X = OR, alkyl, aryl, CCl3, N(alkyl2); R = alkyl cycloalkyl, aryl arylmethyl; (2)-CONHY (Y = H, alkyl, aryl); R<6> = H, halogen, NO2, NH2, OCH3; A = H, phenyl; K = H, CHO, CH2NC5H11, CH2NC4H8NCH3.
1H-PYRROL-1-YL AND 1H-INDOL-1-YL ARYL SULPHONES, PROCESSES FOR THEIR PREPARATION AND USE FOR THE THERAPY OF HIV-1 INFECTIONS
DE MONTIS, ANTONELLA;
1996-01-01
Abstract
This invention relates to new 1H-Pyrrol-1-yl and 1H-Indol-1-yl Aryl Sulphones of Formula (I) that may by useful in the medical therapy of retrovirus infections and in particular of HIV-1 infections. The compounds reported herein may be used alone or in combination with other antiretroviral compounds, preferably chosen among reverse transcriptase inhibitors such as, for example, nucleoside analogues, wherein: R<1> = NO2, NH2, halogen, NHCH2Z(Z = H, alkyl, aryl, heteroaryl), NHCOW (W = H, alkyl, aryl, heteroaryl); R<2> = H, halogen; R<3> = R<4> = H, NO2, NH2, CH3, halogen; R<5> = H, (2)-COX, (3)-COX, (X = OR, alkyl, aryl, CCl3, N(alkyl2); R = alkyl cycloalkyl, aryl arylmethyl; (2)-CONHY (Y = H, alkyl, aryl); R<6> = H, halogen, NO2, NH2, OCH3; A = H, phenyl; K = H, CHO, CH2NC5H11, CH2NC4H8NCH3.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
