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EnglishUltrasonic vocalizations (USVs) have recently emerged as an indicator of the emotional state of rats, and the evaluation of the USVs in the 50-kHz range has been proposed as a tool to investigate the affective properties of drugs of abuse. To clarify the relevance of 50-kHz USVs to drug-induced reward, the acute and long-term effects elicited by different psychoactive drugs [ amphetamine, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), methylphenidate, morphine, and nicotine ] were characterized in adult male rats. Amphetamine and methylphenidate were the only drugs that stimulated the emission of 50-kHz USVs by rats after their acute administration. Moreover, amphetamine was the only drug that elicited a significant emission of 50-kHz USVs after repeated administration. However, rats in all the treatment groups emitted 50-kHz USVs when later re-exposed to the environment previously paired with repeated drug administration, likely indicative of drug-mediated environmental conditioning. Taken together, these results demonstrate the existence of major differences in the acute and long-term effects of different psychoactive drugs on the emission of 50-kHz USVs by rats. Moreover, these results provide a better understanding of the usefulness of 50-kHz USVs as a new tool for the assessment of drug-mediated reward, with implications for the preclinical study of addictive behaviors
| Titolo: | Acute and long-term effects elicited by psychoactive drugs on 50-kHz ultrasonic vocalizations in rats: development of a new experimental tool for the study of drug-mediated reward. |
| Autori: | |
| Data di pubblicazione: | 2014 |
| Abstract: | Ultrasonic vocalizations (USVs) have recently emerged as an indicator of the emotional state of rats, and the evaluation of the USVs in the 50-kHz range has been proposed as a tool to investigate the affective properties of drugs of abuse. To clarify the relevance of 50-kHz USVs to drug-induced reward, the acute and long-term effects elicited by different psychoactive drugs [ amphetamine, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), methylphenidate, morphine, and nicotine ] were characterized in adult male rats. Amphetamine and methylphenidate were the only drugs that stimulated the emission of 50-kHz USVs by rats after their acute administration. Moreover, amphetamine was the only drug that elicited a significant emission of 50-kHz USVs after repeated administration. However, rats in all the treatment groups emitted 50-kHz USVs when later re-exposed to the environment previously paired with repeated drug administration, likely indicative of drug-mediated environmental conditioning. Taken together, these results demonstrate the existence of major differences in the acute and long-term effects of different psychoactive drugs on the emission of 50-kHz USVs by rats. Moreover, these results provide a better understanding of the usefulness of 50-kHz USVs as a new tool for the assessment of drug-mediated reward, with implications for the preclinical study of addictive behaviors |
| Handle: | http://hdl.handle.net/11584/79287 |
| ISBN: | 978-960-474-358-2 |
| Tipologia: | 4.1 Contributo in Atti di convegno |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Simola WSEAS 2014.pdf | versione editoriale | Open Access Visualizza/Apri |
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