| Nome |
# |
|
Identification of Myricetin as Ebolavirus VP35-dsRNA interaction inhibitor through a novel fluorescence-based assay, file e2f56ed8-3c40-3eaf-e053-3a05fe0a5d97
|
924
|
|
N-Acylbenzenesulfonamide dihydro-1,3,4-oxadiazole hybrids: seeking selectivity toward carbonic anhydrase isoforms, file e2f56ed6-c93d-3eaf-e053-3a05fe0a5d97
|
635
|
|
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions, file e2f56ed7-ec87-3eaf-e053-3a05fe0a5d97
|
607
|
|
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors, file e2f56ed7-b882-3eaf-e053-3a05fe0a5d97
|
551
|
|
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques, file e2f56ed7-d7cc-3eaf-e053-3a05fe0a5d97
|
540
|
|
Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids, file e2f56ed8-0acd-3eaf-e053-3a05fe0a5d97
|
525
|
|
Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations, file e2f56ed5-94cf-3eaf-e053-3a05fe0a5d97
|
353
|
|
Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6, file e2f56ed5-3c4f-3eaf-e053-3a05fe0a5d97
|
138
|
|
Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase, file e2f56ed6-c1d3-3eaf-e053-3a05fe0a5d97
|
138
|
|
Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases, file e2f56ed8-8409-3eaf-e053-3a05fe0a5d97
|
133
|
|
Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication, file e2f56eda-a012-3eaf-e053-3a05fe0a5d97
|
123
|
|
Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function, file e2f56ed9-4627-3eaf-e053-3a05fe0a5d97
|
118
|
|
Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation, file e2f56ed8-d9af-3eaf-e053-3a05fe0a5d97
|
106
|
|
New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII, file e2f56ed9-cafd-3eaf-e053-3a05fe0a5d97
|
83
|
|
Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase, file 6ab46032-462e-47f0-bffe-1cded7d2e748
|
67
|
|
Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants, file e2f56ed9-05dc-3eaf-e053-3a05fe0a5d97
|
64
|
|
Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions, file e2f56eda-222c-3eaf-e053-3a05fe0a5d97
|
60
|
|
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase, file e04e01a7-d295-4712-b05a-1faf6cc4ad84
|
54
|
|
Phenylpropenoids from Bupleurum fruticosum as Anti-Human Rhinovirus Species A Selective Capsid Binders, file aff2fd12-4dcd-4a95-a61d-85e67eb8517d
|
41
|
|
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors, file e2f56ed8-1f4f-3eaf-e053-3a05fe0a5d97
|
40
|
|
Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action, file 509260bf-755c-42b4-8509-6236de2ae627
|
37
|
|
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function, file e2f56eda-0989-3eaf-e053-3a05fe0a5d97
|
30
|
|
Targeting tumor associated carbonic anhydrase IX and XII: Highly isozyme selective coumarin and psoralen inhibitors, file 52a060e5-f0f7-41cf-874f-b412c75f203f
|
26
|
|
Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives, file e2f56eda-2aa3-3eaf-e053-3a05fe0a5d97
|
26
|
|
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions, file e2f56ed6-c3c4-3eaf-e053-3a05fe0a5d97
|
18
|
|
Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase, file e2f56ed6-52ca-3eaf-e053-3a05fe0a5d97
|
17
|
|
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action, file 8362faad-16eb-4d5f-8845-2fa29ef1697b
|
14
|
|
Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase, file e2f56ed3-8eb6-3eaf-e053-3a05fe0a5d97
|
12
|
|
2-(2-methyl-2-nitrovinyl)furan but not furvina interfere with staphylococcus aureus agr quorum-sensing system and potentiate the action of fusidic acid against biofilms, file e2f56eda-081b-3eaf-e053-3a05fe0a5d97
|
12
|
|
Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors, file e2f56ed3-b9f3-3eaf-e053-3a05fe0a5d97
|
9
|
|
Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida, file e2f56ed4-f856-3eaf-e053-3a05fe0a5d97
|
9
|
|
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold, file e2f56ed5-9d6f-3eaf-e053-3a05fe0a5d97
|
8
|
|
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions, file e2f56ed6-be95-3eaf-e053-3a05fe0a5d97
|
7
|
|
Phenylpropenoids from Bupleurum fruticosum as Anti-Human Rhinovirus Species A Selective Capsid Binders, file e2f56ed7-0026-3eaf-e053-3a05fe0a5d97
|
7
|
|
Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production, file e2f56eda-723b-3eaf-e053-3a05fe0a5d97
|
7
|
|
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B, file e2f56ed4-6d25-3eaf-e053-3a05fe0a5d97
|
6
|
|
Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication, file e2f56ed5-2f58-3eaf-e053-3a05fe0a5d97
|
6
|
|
Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors, file e2f56ed5-352a-3eaf-e053-3a05fe0a5d97
|
6
|
|
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases, file e2f56ed4-7606-3eaf-e053-3a05fe0a5d97
|
5
|
|
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII, file e2f56ed5-734a-3eaf-e053-3a05fe0a5d97
|
5
|
|
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides, file e2f56ed7-889b-3eaf-e053-3a05fe0a5d97
|
5
|
|
2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms, file 7091c921-6623-4325-9501-876b1b7d2391
|
4
|
|
Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea, file aeb61d46-b980-4f88-863c-75ccc0bc3ff8
|
4
|
|
Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement, file e2f56ed6-006d-3eaf-e053-3a05fe0a5d97
|
4
|
|
Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor, file 80744b2f-2ffb-4412-a9d7-ba6ea0064377
|
3
|
|
null, file e2f56ed4-75c8-3eaf-e053-3a05fe0a5d97
|
3
|
|
N-Alkyl dien- and trienamides from the roots of Otanthus maritimus with binding affinity for opioid and cannabinoid receptors, file e2f56ed4-dfe3-3eaf-e053-3a05fe0a5d97
|
3
|
|
Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B, file e2f56ed6-bf4f-3eaf-e053-3a05fe0a5d97
|
3
|
|
Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action, file e2f56ed6-d1cc-3eaf-e053-3a05fe0a5d97
|
3
|
|
Ferulic Acid Esters and Withanolides: in Search of Withania somnifera GABAA Receptor Modulators, file e2f56ed8-7a68-3eaf-e053-3a05fe0a5d97
|
3
|
|
null, file e2f56ed3-8e1e-3eaf-e053-3a05fe0a5d97
|
2
|
|
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach, file e2f56ed3-b97f-3eaf-e053-3a05fe0a5d97
|
2
|
|
Synthesis and characterization of new phthalhydrazothiazole derivatives: A preliminary investigation on their activity against hepatocellular carcinoma, file e2f56ed3-bad5-3eaf-e053-3a05fe0a5d97
|
2
|
|
3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B, file e2f56ed4-760b-3eaf-e053-3a05fe0a5d97
|
2
|
|
Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies, file e2f56ed5-e9f3-3eaf-e053-3a05fe0a5d97
|
2
|
|
null, file e2f56ed8-0c47-3eaf-e053-3a05fe0a5d97
|
2
|
|
Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization, file e2f56ed9-8b0f-3eaf-e053-3a05fe0a5d97
|
2
|
|
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and Ribonuclease H activities effective also on non-nucleoside resistant RTs, file e2f56ed3-9acc-3eaf-e053-3a05fe0a5d97
|
1
|
|
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase (RT) -associated DNA polymerase and Ribonuclease H (RNase H) activities effective also on the RNase H activity of non-nucleoside resistant RTs, file e2f56ed3-9b48-3eaf-e053-3a05fe0a5d97
|
1
|
|
GRID-based three-dimensional pharmacophores II: PharmBench, a benchmark data set for evaluating pharmacophore elucidation methods, file e2f56ed3-9c8f-3eaf-e053-3a05fe0a5d97
|
1
|
|
Synthesis and anti-microbial activity evaluation of some new 1-benzoyl-isothiosemicarbazides., file e2f56ed3-b025-3eaf-e053-3a05fe0a5d97
|
1
|
|
Shape based computer aided similarity screening: a valid tool in the discovery of new scaffolds for the inhibition of HIV-1 reverse transcriptase associated ribonuclease H function, file e2f56ed3-bc59-3eaf-e053-3a05fe0a5d97
|
1
|
|
Mutagenic study on HIV-1 reverse transcriptase to explore the mechanism of action of HIV-1 reverse transcriptase dual inhibitors, file e2f56ed3-be80-3eaf-e053-3a05fe0a5d97
|
1
|
|
The polymorphisms of DNA G-quadruplex investigated by docking experiments with telomestatin enantiomers, file e2f56ed4-75ca-3eaf-e053-3a05fe0a5d97
|
1
|
|
Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data, file e2f56ed5-9457-3eaf-e053-3a05fe0a5d97
|
1
|
|
Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders, file e2f56ed5-9d79-3eaf-e053-3a05fe0a5d97
|
1
|
|
A novel series of 3,4-disubstituted dihydropyrazoles: Synthesis and evaluation for MAO enzyme inhibition, file e2f56ed5-fa36-3eaf-e053-3a05fe0a5d97
|
1
|
|
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors, file e2f56ed6-0477-3eaf-e053-3a05fe0a5d97
|
1
|
|
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors, file e2f56ed6-c774-3eaf-e053-3a05fe0a5d97
|
1
|
|
null, file e2f56ed7-f2f5-3eaf-e053-3a05fe0a5d97
|
1
|
|
Molecular interaction fields in drug discovery: Recent advances and future perspectives, file e2f56ed7-fd45-3eaf-e053-3a05fe0a5d97
|
1
|
|
null, file e2f56ed8-08f0-3eaf-e053-3a05fe0a5d97
|
1
|
|
How To optimize shape-based virtual screening: Choosing the right query and including chemical information, file e2f56ed8-20fb-3eaf-e053-3a05fe0a5d97
|
1
|
|
null, file e2f56ed8-6112-3eaf-e053-3a05fe0a5d97
|
1
|
|
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques, file eb055314-2295-4bdc-a99f-a47e5918eb5e
|
1
|
| Totale |
5.634 |