Kainic acid was used to clarify the source of nigral GABA-ergic terminals. Rats were microinjected unilaterally with kainic acid in the globus pallidus, head, body and tail of the caudate. Lesions of the pallidus resulted in a non-significative (5.5 %) reduction of nigral GAD. Kainic-lesions of the head of the caudate resulted in a significative (19%) drop of nigral GAD, while lesions of the caudate body resulted in the largest reduction of nigral GAD (53%). Lesions of the caudate tail were without effect. These results indicate that nigral GAD arises mostly from the body and in part, also from the head of the caudate but not from the globus pallidus or from the tail of the caudate.
Origin of GABA-ergic strio-nigral neurons as studied by kainate-induced lesions
MORELLI, MICAELA;DI CHIARA, GAETANO
1980-01-01
Abstract
Kainic acid was used to clarify the source of nigral GABA-ergic terminals. Rats were microinjected unilaterally with kainic acid in the globus pallidus, head, body and tail of the caudate. Lesions of the pallidus resulted in a non-significative (5.5 %) reduction of nigral GAD. Kainic-lesions of the head of the caudate resulted in a significative (19%) drop of nigral GAD, while lesions of the caudate body resulted in the largest reduction of nigral GAD (53%). Lesions of the caudate tail were without effect. These results indicate that nigral GAD arises mostly from the body and in part, also from the head of the caudate but not from the globus pallidus or from the tail of the caudate.
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