Synthesis and mu-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives

Barlocco, D; Cignarella, G; Vianello, P; Villa, S; Pinna, Ga; Fadda, Paola; Fratta, Walter

doi:10.1016/S0014-827X(98)00065-2

A new series of analogues (1c-j; 2c-i) of the previously reported analgesic 3,8-diazabicyclo[3.2.1]octanes (1a,b; 2a,b) was synthesized and tested for their affinity towards mu-opioid receptors. Modifications were introduced either at the cinnamyl or the acyl side chains. The majority of the new compounds, with the exception of 1c,j and 2c, showed K-i values better or comparable with those of the models. (C) 1998 Elsevier Science S.A. All rights reserved.

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Titolo:	Synthesis and mu-opioid receptor affinity of a new series of nitro substituted 3,8-diazabicyclo[3.2.1]octane derivatives
Autori:	Barlocco D Cignarella G Vianello P Villa S Pinna GA FADDA, PAOLA FRATTA, WALTER mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1998
Rivista:	IL FARMACO
Handle:	http://hdl.handle.net/11584/102175
Tipologia:	1.1 Articolo in rivista

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