Bilateral intranigral administration of GABA-receptor blockers (picrotoxin or bicuculline) elicits catatonia not surmountable by administration of apomorphine, a dopamine (DA)-receptor agonist. Unilateral intranigral administration of GABA-receptor blockers ipsilateral to a lesion of nigro-striatal DA-neurons induced with 60H-DA, antagonizes the contralateral turning produced by apomorphine. The results indicate that behaviouralresponseselicited by striatal DA-receptorstimulation are effected through a GABA-mediated inhibition of pars reticulata neurons.
Evidence that nigral GABA mediates behavioural responses elicited by striatal dopamine receptor stimulation.
DI CHIARA, GAETANO;MORELLI, MICAELA;
1978-01-01
Abstract
Bilateral intranigral administration of GABA-receptor blockers (picrotoxin or bicuculline) elicits catatonia not surmountable by administration of apomorphine, a dopamine (DA)-receptor agonist. Unilateral intranigral administration of GABA-receptor blockers ipsilateral to a lesion of nigro-striatal DA-neurons induced with 60H-DA, antagonizes the contralateral turning produced by apomorphine. The results indicate that behaviouralresponseselicited by striatal DA-receptorstimulation are effected through a GABA-mediated inhibition of pars reticulata neurons.
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