p53 abnormalities are frequently (20-40%) reported in female breast cancer (FBC) and often correlated with poor prognosis. Relatively few are the studies on its expression and mutation and correlation with prognosis in MBC. However, while some data (ASCO 1994, 1276) indicate that MBC rarely overexpress p53 protein, others support that it is similar to the female (Cancer 1995, 75, 2233). Twenty-nine consecutive non metastatic MBC were studied for prognostic factors (size, nodes, grading, ER, PgR, Ki-67 L.I./PCNA) and (in 21 pts) for monoclonal mouse anti-human p53 protein (DAKO-p53, D07) on formalin-fixed-embedded tissue sections. Staining was assessed by the number of cells and the intensity of the cells staining. Positivity was considered when > 20% of cells stained. The median pt age was 65 years; there were 23 infiltracting ductal (79.3%), 3 1obular (10.3%), 2 tubular (6.9%) and 1 apocrine (3.4%); 17 (58.6%) pts have LN involvement. All pts underwent mastectomy (radical in 24 pts). Of the 21 pts, 6 (28.6%) were positive for p53 and there was a trend for p53 positivity to be N+ and ER - and no correlation for size, grading and Ki-67 L.I. For the entire group five- and 10-year Kaplan-Meier time to progression rates were 45% and 30% and overall survival 55% and 40% respectively. No significant differences in DFS and OS were found with respect to size (p = 0.46; p = 0.35), grading (p = 0.54; p = 0.24), ER (p = 0.64; p = 0.23), PgR (p = 0.54; p = 0.11) and p53 (p = 0.83; p = 0.49) while at 5-year follow-up, node and Ki-67 L.I. negative group had a statistically significant higher DFS (p = 0.02) and OS (p = 0.007) than the positive group. At 10-year only the Ki-67 L.I. was predictive of DFS (p = 0.027) and OS (p = 0.007). At least in this series the incidence of p53 positivity is concordant with the FBC and, moreover, our data did not provide the p53 a useful predictor of disease-specific-and overall survival. Nodes and Ki-67 L.I. were significant predictors in worse survival.
PROGNOSTIC SIGNIFICANCE OF P53 PROTEIN ACCUMULATION IN MALE BREAST CANCER (MBC)
CALO', PIETRO GIORGIO;
1996-01-01
Abstract
p53 abnormalities are frequently (20-40%) reported in female breast cancer (FBC) and often correlated with poor prognosis. Relatively few are the studies on its expression and mutation and correlation with prognosis in MBC. However, while some data (ASCO 1994, 1276) indicate that MBC rarely overexpress p53 protein, others support that it is similar to the female (Cancer 1995, 75, 2233). Twenty-nine consecutive non metastatic MBC were studied for prognostic factors (size, nodes, grading, ER, PgR, Ki-67 L.I./PCNA) and (in 21 pts) for monoclonal mouse anti-human p53 protein (DAKO-p53, D07) on formalin-fixed-embedded tissue sections. Staining was assessed by the number of cells and the intensity of the cells staining. Positivity was considered when > 20% of cells stained. The median pt age was 65 years; there were 23 infiltracting ductal (79.3%), 3 1obular (10.3%), 2 tubular (6.9%) and 1 apocrine (3.4%); 17 (58.6%) pts have LN involvement. All pts underwent mastectomy (radical in 24 pts). Of the 21 pts, 6 (28.6%) were positive for p53 and there was a trend for p53 positivity to be N+ and ER - and no correlation for size, grading and Ki-67 L.I. For the entire group five- and 10-year Kaplan-Meier time to progression rates were 45% and 30% and overall survival 55% and 40% respectively. No significant differences in DFS and OS were found with respect to size (p = 0.46; p = 0.35), grading (p = 0.54; p = 0.24), ER (p = 0.64; p = 0.23), PgR (p = 0.54; p = 0.11) and p53 (p = 0.83; p = 0.49) while at 5-year follow-up, node and Ki-67 L.I. negative group had a statistically significant higher DFS (p = 0.02) and OS (p = 0.007) than the positive group. At 10-year only the Ki-67 L.I. was predictive of DFS (p = 0.027) and OS (p = 0.007). At least in this series the incidence of p53 positivity is concordant with the FBC and, moreover, our data did not provide the p53 a useful predictor of disease-specific-and overall survival. Nodes and Ki-67 L.I. were significant predictors in worse survival.
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