Psoriasis and psoriatic arthritis are linked diseases characterised by (distinct?) immune-mediated pathogenetic mechanisms and by a genetic background interacting with environmental factors. Some candidate susceptibility genes have been studied extensively; they include HLA genes, genes within the HLA region and genes outside the HLA region; among them corneodesmosin and other genes of PSORS1 region, MICA and TNF-a polymorphisms. The main findings in the literature are discussed.
Genetics of psoriasis and psoriatic arthritis
CAULI, ALBERTO;VACCA, ALESSANDRA;PIGA, MATTEO;
2007-01-01
Abstract
Psoriasis and psoriatic arthritis are linked diseases characterised by (distinct?) immune-mediated pathogenetic mechanisms and by a genetic background interacting with environmental factors. Some candidate susceptibility genes have been studied extensively; they include HLA genes, genes within the HLA region and genes outside the HLA region; among them corneodesmosin and other genes of PSORS1 region, MICA and TNF-a polymorphisms. The main findings in the literature are discussed.
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