The preparation of twelve aminoalkanol derivatives of 2,3-dihydro-5H-[1,4] dithiino[2,3-c]pyrrole- 5,7(6H)-dione was described. Newly obtained compounds, as well as their propyl and butyl analogues, were evaluated in vitro against selected viruses. Selected derivatives were tested for their antibacterial and antifungal activity. Compounds 3h, 3j, 4b and 5a-d showed moderate to significant protections against CVB-2, HSV-1 and YFV viruses. The molecular structures of 4a, 5c and 5g were determined by an X-ray analysis.

Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents

TAMBURINI, ELENA;LODDO, ROBERTA
2011-01-01

Abstract

The preparation of twelve aminoalkanol derivatives of 2,3-dihydro-5H-[1,4] dithiino[2,3-c]pyrrole- 5,7(6H)-dione was described. Newly obtained compounds, as well as their propyl and butyl analogues, were evaluated in vitro against selected viruses. Selected derivatives were tested for their antibacterial and antifungal activity. Compounds 3h, 3j, 4b and 5a-d showed moderate to significant protections against CVB-2, HSV-1 and YFV viruses. The molecular structures of 4a, 5c and 5g were determined by an X-ray analysis.
2011
1,4-Dithiine; Antiviral activity; Conformations; X-ray analysis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/104839
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