Several monocyclic derivatives structurally related to the mu-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane have been synthesized and tested in binding studies using the mu-selective H-3-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards mu-opioid receptors.
Monocyclic Analogues of the µ-Opioid Agonist 3,8-Diazabicyclo-[3.2.1]octanes: Synthesis, Modeling, and Activity
FRATTA, WALTER;FADDA, PAOLA;
1995-01-01
Abstract
Several monocyclic derivatives structurally related to the mu-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane have been synthesized and tested in binding studies using the mu-selective H-3-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards mu-opioid receptors.
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