Proconflinct effect of ACTH 1-24: interaction with benzodiazepines

Corda, Maria Giuseppa; Orlandi, M; Fratta, Walter

doi:10.1016/0091-3057(90)90267-L

The intracerebroventricular injection of ACTH1-24 (0.1-10 micrograms) produced a dose-dependent decrease of punished licking periods in the conflict test in rats. The same treatment failed to modify unpunished behavior. A similar effect was produced by alpha-MSH (0.25-5 micrograms), whereas ACTH4-10 and ACTH11-24 were ineffective in doses up to 10 micrograms. The proconflict effect of ACTH1-24 was completely antagonized by diazepam (1.5 mg/kg IP) and partially by the benzodiazepine receptor antagonist Ro 15-1788 (5 mg/kg IP). The results are in line with a possible "anxiogenic" action of ACTH1-24.

Proconflinct effect of ACTH 1-24: interaction with benzodiazepines / Corda M G; Orlandi M; Fratta W. - 36(1990), pp. 631-634.

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Titolo:	Proconflinct effect of ACTH 1-24: interaction with benzodiazepines
Autori:	CORDA, MARIA GIUSEPPA Orlandi M FRATTA, WALTER mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1990
Rivista:	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Citazione:	Proconflinct effect of ACTH 1-24: interaction with benzodiazepines / Corda M G; Orlandi M; Fratta W. - 36(1990), pp. 631-634.
Abstract:	The intracerebroventricular injection of ACTH1-24 (0.1-10 micrograms) produced a dose-dependent decrease of punished licking periods in the conflict test in rats. The same treatment failed to modify unpunished behavior. A similar effect was produced by alpha-MSH (0.25-5 micrograms), whereas ACTH4-10 and ACTH11-24 were ineffective in doses up to 10 micrograms. The proconflict effect of ACTH1-24 was completely antagonized by diazepam (1.5 mg/kg IP) and partially by the benzodiazepine receptor antagonist Ro 15-1788 (5 mg/kg IP). The results are in line with a possible "anxiogenic" action of ACTH1-24.
Handle:	http://hdl.handle.net/11584/1067
Tipologia:	1.1 Articolo in rivista

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