Proconflinct effect of ACTH 1-24: interaction with benzodiazepines

The intracerebroventricular injection of ACTH1-24 (0.1-10 micrograms) produced a dose-dependent decrease of punished licking periods in the conflict test in rats. The same treatment failed to modify unpunished behavior. A similar effect was produced by alpha-MSH (0.25-5 micrograms), whereas ACTH4-10 and ACTH11-24 were ineffective in doses up to 10 micrograms. The proconflict effect of ACTH1-24 was completely antagonized by diazepam (1.5 mg/kg IP) and partially by the benzodiazepine receptor antagonist Ro 15-1788 (5 mg/kg IP). The results are in line with a possible "anxiogenic" action of ACTH1-24.

Proconflinct effect of ACTH 1-24: interaction with benzodiazepines / Corda M G; Orlandi M; Fratta W. - 36(1990), pp. 631-634.

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Titolo: Proconflinct effect of ACTH 1-24: interaction with benzodiazepines
Autori: 
CORDA, MARIA GIUSEPPA
FRATTA, WALTER
mostra contributor esterni 
Data di pubblicazione: 1990
Rivista: 
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR  
Citazione: Proconflinct effect of ACTH 1-24: interaction with benzodiazepines / Corda M G; Orlandi M; Fratta W. - 36(1990), pp. 631-634.
Abstract: The intracerebroventricular injection of ACTH1-24 (0.1-10 micrograms) produced a dose-dependent decrease of punished licking periods in the conflict test in rats. The same treatment failed to modify unpunished behavior. A similar effect was produced by alpha-MSH (0.25-5 micrograms), whereas ACTH4-10 and ACTH11-24 were ineffective in doses up to 10 micrograms. The proconflict effect of ACTH1-24 was completely antagonized by diazepam (1.5 mg/kg IP) and partially by the benzodiazepine receptor antagonist Ro 15-1788 (5 mg/kg IP). The results are in line with a possible "anxiogenic" action of ACTH1-24.
Handle: http://hdl.handle.net/11584/1067
Tipologia:1.1 Articolo in rivista

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