The intracerebroventricular injection of ACTH1-24 (0.1-10 micrograms) produced a dose-dependent decrease of punished licking periods in the conflict test in rats. The same treatment failed to modify unpunished behavior. A similar effect was produced by alpha-MSH (0.25-5 micrograms), whereas ACTH4-10 and ACTH11-24 were ineffective in doses up to 10 micrograms. The proconflict effect of ACTH1-24 was completely antagonized by diazepam (1.5 mg/kg IP) and partially by the benzodiazepine receptor antagonist Ro 15-1788 (5 mg/kg IP). The results are in line with a possible "anxiogenic" action of ACTH1-24.
Proconflinct effect of ACTH 1-24: interaction with benzodiazepines / Corda M G; Orlandi M; Fratta W. - 36(1990), pp. 631-634.
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Titolo: | Proconflinct effect of ACTH 1-24: interaction with benzodiazepines | |
Autori: | ||
Data di pubblicazione: | 1990 | |
Rivista: | ||
Citazione: | Proconflinct effect of ACTH 1-24: interaction with benzodiazepines / Corda M G; Orlandi M; Fratta W. - 36(1990), pp. 631-634. | |
Abstract: | The intracerebroventricular injection of ACTH1-24 (0.1-10 micrograms) produced a dose-dependent decrease of punished licking periods in the conflict test in rats. The same treatment failed to modify unpunished behavior. A similar effect was produced by alpha-MSH (0.25-5 micrograms), whereas ACTH4-10 and ACTH11-24 were ineffective in doses up to 10 micrograms. The proconflict effect of ACTH1-24 was completely antagonized by diazepam (1.5 mg/kg IP) and partially by the benzodiazepine receptor antagonist Ro 15-1788 (5 mg/kg IP). The results are in line with a possible "anxiogenic" action of ACTH1-24. | |
Handle: | http://hdl.handle.net/11584/1067 | |
Tipologia: | 1.1 Articolo in rivista |