Interferons (IFN) are well known triggers of immunomediated diseases in genetically predisposed subjects. We describe the unique case of a HLAB*2 709 positive subject who underwent IFN-alpha treatment for essential thrombocythentia and developed arthritis of the proximal interphalangeal joints of the hands but not sacroiliitis. The possible mechanisms of IFN-induced arthritis are discussed.
HLA-B*2709 and lack of susceptibility to sacroiliitis: further support from the clinic
CAULI, ALBERTO;VACCA, ALESSANDRA;PIGA, MATTEO;MATHIEU, ALESSANDRO
2008-01-01
Abstract
Interferons (IFN) are well known triggers of immunomediated diseases in genetically predisposed subjects. We describe the unique case of a HLAB*2 709 positive subject who underwent IFN-alpha treatment for essential thrombocythentia and developed arthritis of the proximal interphalangeal joints of the hands but not sacroiliitis. The possible mechanisms of IFN-induced arthritis are discussed.
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