An organic ultra-low voltage field effect transistor for DNA hybridization detection is presented. The transduction mechanism is based on a field-effect modulation due to the electrical charge of the oligonucleotides, so label-free detection can be performed. The device shows sub-nanometrical detection limit and unprecedented selectivity with respect to single nucleotide polymorphism.
Ultra-Low Voltage, OTFT-Based Sensor for Label-Free DNA Detection
LAI, STEFANO;DEMELAS, MONIA;CASULA, GIULIA;COSSEDDU, PIERO;BARBARO, MASSIMO;BONFIGLIO, ANNALISA
2013-01-01
Abstract
An organic ultra-low voltage field effect transistor for DNA hybridization detection is presented. The transduction mechanism is based on a field-effect modulation due to the electrical charge of the oligonucleotides, so label-free detection can be performed. The device shows sub-nanometrical detection limit and unprecedented selectivity with respect to single nucleotide polymorphism.
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