An organic ultra-low voltage field effect transistor for DNA hybridization detection is presented. The transduction mechanism is based on a field-effect modulation due to the electrical charge of the oligonucleotides, so label-free detection can be performed. The device shows sub-nanometrical detection limit and unprecedented selectivity with respect to single nucleotide polymorphism.

Ultra-Low Voltage, OTFT-Based Sensor for Label-Free DNA Detection

LAI, STEFANO;DEMELAS, MONIA;CASULA, GIULIA;COSSEDDU, PIERO;BARBARO, MASSIMO;BONFIGLIO, ANNALISA
2013-01-01

Abstract

An organic ultra-low voltage field effect transistor for DNA hybridization detection is presented. The transduction mechanism is based on a field-effect modulation due to the electrical charge of the oligonucleotides, so label-free detection can be performed. The device shows sub-nanometrical detection limit and unprecedented selectivity with respect to single nucleotide polymorphism.
2013
DNA hybridization sensor; organic biosensor; organic chemosensor; organic field effect transistor; ultra-low voltage device
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/109300
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