HINDERED NUCLEOSIDE ANALOGS (HNA) AS ANTIFLAVIVIRIDAE AGENTS

Manfredini, S; Angusti, A; Veronese, Ac; Durini, E; Vertuani, S; Nalin, F; Solaroli, N; Ferrone, M; Pricl, S; Mura, M; Piano, Ma; Poddesu, B; Cadeddu, A; La Colla, P; Loddo, Roberta

Flaviviridae are an important family of viruses, responsible for widely spread diseases such as dengue and West Nile fever and hepatitis C. Despite the severity of the related diseases, no effective antiviral treatments for infection are available. Following our discovery of adenosine-hindered analogs as potent antiflaviviridae agents, we have continued our investigation on guanosine and inosine derivatives, which were evaluated for activity against BVDV, YFV, DENV, and WNV viruses in cell-based assays. The present study allowed us to identify some newer features that led to improve the antiviral potency (down to the μM range) and to selectively inhibit BVDV and YFV viruses. The molecular modeling results were consistent with the hypothesis that test analogs act as RNA-dependent RNA polymerase (RdRp) inhibitors by interacting with a surface allosteric binding pocket.

Scheda prodotto non validato

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Trovami (UniCASearch)

Titolo:	HINDERED NUCLEOSIDE ANALOGS (HNA) AS ANTIFLAVIVIRIDAE AGENTS
Autori:	MANFREDINI S ANGUSTI A VERONESE AC DURINI E VERTUANI S NALIN F SOLAROLI N FERRONE M PRICL S MURA M PIANO MA PODDESU B CADEDDU A LA COLLA P LODDO, ROBERTA mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2004
Rivista:	PURE AND APPLIED CHEMISTRY
Abstract:	Flaviviridae are an important family of viruses, responsible for widely spread diseases such as dengue and West Nile fever and hepatitis C. Despite the severity of the related diseases, no effective antiviral treatments for infection are available. Following our discovery of adenosine-hindered analogs as potent antiflaviviridae agents, we have continued our investigation on guanosine and inosine derivatives, which were evaluated for activity against BVDV, YFV, DENV, and WNV viruses in cell-based assays. The present study allowed us to identify some newer features that led to improve the antiviral potency (down to the μM range) and to selectively inhibit BVDV and YFV viruses. The molecular modeling results were consistent with the hypothesis that test analogs act as RNA-dependent RNA polymerase (RdRp) inhibitors by interacting with a surface allosteric binding pocket.
Handle:	http://hdl.handle.net/11584/13008
Tipologia:	1.1 Articolo in rivista

File in questo prodotto:

Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

UNICA IRIS Institutional Research Information System

Scheda prodotto non validato

File in questo prodotto: