Coumarins from Opopanax chironium, new dihydrofuranocumarins and differential induction of apoptosis by imperatorin and heraclenin

Appendino, G; Bianchi, F; Bader, A; Campagnuolo, C; Fattorusso, E; Taglialatela Scafati, O; Blanco Molina, M; Macho, A; Fiebich, Bl; Bremner, P; Heinrich, M; Ballero, Mauro; Munoz, E.

Opopanax chironium is a rich source of furano- and dihydrofuranocoumarins, whose accumulation in all plant parts and especially the roots is presumably responsible for the poisonous properties of the species. The presence of two distinct chemotypes was evidenced, with the one from Sicily affording the new dihydrofuranocoumarins 5d and 5e, while extracts from the Sardinian chemotype showed powerful apoptotic activity, which was traced to the prenylated furanocoumarins heraclenin (2a) and imperatorin (2b). Despite a close structural similarity, compounds 2a and 2b induced apoptosis in Jurkat leukemia cells in mechanistically different ways.

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Titolo:	Coumarins from Opopanax chironium, new dihydrofuranocumarins and differential induction of apoptosis by imperatorin and heraclenin
Autori:	APPENDINO G BIANCHI F BADER A CAMPAGNUOLO C FATTORUSSO E TAGLIALATELA SCAFATI O BLANCO MOLINA M MACHO A FIEBICH BL BREMNER P HEINRICH M BALLERO, MAURO MUNOZ E. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2004
Rivista:	JOURNAL OF NATURAL PRODUCTS
Abstract:	Opopanax chironium is a rich source of furano- and dihydrofuranocoumarins, whose accumulation in all plant parts and especially the roots is presumably responsible for the poisonous properties of the species. The presence of two distinct chemotypes was evidenced, with the one from Sicily affording the new dihydrofuranocoumarins 5d and 5e, while extracts from the Sardinian chemotype showed powerful apoptotic activity, which was traced to the prenylated furanocoumarins heraclenin (2a) and imperatorin (2b). Despite a close structural similarity, compounds 2a and 2b induced apoptosis in Jurkat leukemia cells in mechanistically different ways.
Handle:	http://hdl.handle.net/11584/13316
Tipologia:	1.1 Articolo in rivista

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