The antithyroid drug methimazole (MMI) reacts with molecular iodine to form, in a multistep process, 1-methylimidazole as final product. In this process, the charge transfer complex MMI-I2 and the ionic disulfide [(C4H6N2S–)2]2+ (1, dication MMI disulfide) have been isolated and their X-ray crystal structures solved. Dication MMI disulfide perchlorate acts effectively both in reducing I2 to I- ions and in showing antioxidant properties in inactivating the enzyme lactoperoxidase compound I.
|Titolo:||Interaction of Methimazole with I2: X-ray Crystal Structure of the Charge Transfer Complex Methimazole-I2. Implications for the Mechanism of Action of Methimazole-Based Antithyroid Drugs|
|Data di pubblicazione:||2008|
|Citazione:||Interaction of Methimazole with I2: X-ray Crystal Structure of the Charge Transfer Complex Methimazole-I2. Implications for the Mechanism of Action of Methimazole-Based Antithyroid Drugs / F. ISAIA; M.C. ARAGONI; M. ARCA; F. DEMARTIN; F.A. DEVILLANOVA; G. FLORIS; A. GARAU; M.B. HURSTHOUSE; LIPPOLIS V; R. MEDDA; F. OPPO; M. PIRA; G. VERANI. - 51:13(2008), pp. 4050-4053.|
|Tipologia:||1.1 Articolo in rivista|