Abstract: Purpose: This study was conducted to evaluate the effects of two different oral contraceptives (OCs) on homocysteine (Hcy) metabolism in 20 women with polycystic ovary syndrome (PCOS). Methods: Women were randomly allocated to receive either the biphasic OC containing 40/30 mu g ethynylestradiol (EE)+25/125 mu g desogestrel (DSG; n = 10) or the monophasic OC containing 35 mu g EE and 2 mg cyproterone acetate (CPA; n = 10). Investigations were performed before and after 6 months of treatment. Fasting vitamin B-12, folate, Hcy and insulin sensitivity (SI), and glucose utilization independent of insulin (Sg), by the minimal model method, were evaluated. Results: Folate and vitamin B-12 were not significantly modified by either OC. EE/DSG decreased ST (2.53 +/- 0.35 vs. 1.68 +/- 0.45; p <.05), without modifying Hey (9.54 +/- 0.7 mu mol/L vs. 9.18 +/- 0.6 mu mol/L). EE/CPA improved SI (1.47 +/- 0.38 vs. 3.27 +/- 0.48; p <.04) and decreased Hcy (9.8 +/- 1.9 mu mol/L vs. 7.9 +/- 0.9 mu mol/L; p <.05). This study indicates that in women with PCOS, EE/CPA, but not EE/DSG, improves IS and decreases fasting Hey. (c) 2006 Elsevier Inc. All rights reserved.
Effects of two different oral contraceptives on homocysteine metabolism in women with polycystic ovary syndrome
PAOLETTI, ANNA MARIA;
2006-01-01
Abstract
Abstract: Purpose: This study was conducted to evaluate the effects of two different oral contraceptives (OCs) on homocysteine (Hcy) metabolism in 20 women with polycystic ovary syndrome (PCOS). Methods: Women were randomly allocated to receive either the biphasic OC containing 40/30 mu g ethynylestradiol (EE)+25/125 mu g desogestrel (DSG; n = 10) or the monophasic OC containing 35 mu g EE and 2 mg cyproterone acetate (CPA; n = 10). Investigations were performed before and after 6 months of treatment. Fasting vitamin B-12, folate, Hcy and insulin sensitivity (SI), and glucose utilization independent of insulin (Sg), by the minimal model method, were evaluated. Results: Folate and vitamin B-12 were not significantly modified by either OC. EE/DSG decreased ST (2.53 +/- 0.35 vs. 1.68 +/- 0.45; p <.05), without modifying Hey (9.54 +/- 0.7 mu mol/L vs. 9.18 +/- 0.6 mu mol/L). EE/CPA improved SI (1.47 +/- 0.38 vs. 3.27 +/- 0.48; p <.04) and decreased Hcy (9.8 +/- 1.9 mu mol/L vs. 7.9 +/- 0.9 mu mol/L; p <.05). This study indicates that in women with PCOS, EE/CPA, but not EE/DSG, improves IS and decreases fasting Hey. (c) 2006 Elsevier Inc. All rights reserved.
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